Aldosterone, the Mineralocorticoid Receptor and Mechanisms of Cardiovascular Disease

Morag J. Young, Gail K. Adler

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

2 Citations (Scopus)

Abstract

The mineralocorticoid receptor (MR) and aldosterone play a critical role in the regulation of plasma volume homeostasis and are critical for the control of normal physiological regulation blood pressure (BP) and organ perfusion and as a potent mediator of hypertension. Aldosterone and the MR also play a key role in regulating tissue volume expansion in many tissues, via the regulation of hypertrophy and/or hyperplasia of cardiac or vascular smooth muscle cells and through regulation of the extra cellular matrix (ECM) and tissue fibrosis. Over the last two decades since the Randomized ALdactone Evaluation Study (RALES) trial it has become apparent that increased MR signaling is much more than electrolyte homeostasis and plasma volume. RALES demonstrated a key protective effect of MRA in severe heart failure and stimulated significant new research to understand the actions of the MR and its ligands on the heart and vascular system, the outcomes of which will be discussed in this chapter.

Original languageEnglish
Title of host publicationVitamins and Hormones
EditorsGerald Litwack
PublisherAcademic Press
Pages361-385
Number of pages25
ISBN (Print)9780128177822
DOIs
Publication statusPublished - 1 Jan 2019
Externally publishedYes

Publication series

NameVitamins and Hormones
PublisherAcademic Press
Volume109
ISSN (Print)0083-6729
ISSN (Electronic)2162-2620

Keywords

  • Aldosterone
  • Cardiac fibrosis
  • Cardiac risk
  • Heart failure
  • Mineralocorticoid receptor
  • Vascular dysfunction

Cite this

Young, M. J., & Adler, G. K. (2019). Aldosterone, the Mineralocorticoid Receptor and Mechanisms of Cardiovascular Disease. In G. Litwack (Ed.), Vitamins and Hormones (pp. 361-385). (Vitamins and Hormones; Vol. 109). Academic Press. https://doi.org/10.1016/bs.vh.2018.10.003