Aldosterone secretion and action

Peter J Fuller; Morag J Young

doi:10.1016/B978-0-323-18907-1.00101-3

Aldosterone secretion and action

Peter J Fuller, Morag J Young

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review

3 Citations (Scopus)

Abstract

Aldosterone activates the mineralocorticoid receptor (MR), a member of the nuclear receptor superfamily. Aldosterone synthesis/secretion is primarily regulated by angiotensin II nd potassium as part of two parallel feedback loops. The MR is unique, being the receptor for two physiologic ligands: aldosterone and cortisol. Aldosterone selectivity of the MR in epithelial tissues is conferred by 11 hydroxysteroid dehydrogenase type II. Activation of the MR in nonepithelial tissue is associated with a proinflammatory, profibrotic response connected with the adverse cardiovascular outcome, seen with aldosterone excess.

Original language	English
Title of host publication	Endocrinology
Subtitle of host publication	Adult and Pediatric
Editors	J Larry Jameson, Leslie J De Groot, David M de Kretser, Linda C Giudice, Ashley B Grossman, Shlomo Melmed, John T Potts Jr, Gordon C Weir
Place of Publication	Philadelphia PA USA
Publisher	Elsevier
Pages	1756-1762
Number of pages	7
Volume	2
Edition	7th
ISBN (Print)	9780323189071
DOIs	https://doi.org/10.1016/B978-0-323-18907-1.00101-3
Publication status	Published - 2016

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10.1016/B978-0-323-18907-1.00101-3

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title = "Aldosterone secretion and action",

abstract = "Aldosterone activates the mineralocorticoid receptor (MR), a member of the nuclear receptor superfamily. Aldosterone synthesis/secretion is primarily regulated by angiotensin II nd potassium as part of two parallel feedback loops. The MR is unique, being the receptor for two physiologic ligands: aldosterone and cortisol. Aldosterone selectivity of the MR in epithelial tissues is conferred by 11 hydroxysteroid dehydrogenase type II. Activation of the MR in nonepithelial tissue is associated with a proinflammatory, profibrotic response connected with the adverse cardiovascular outcome, seen with aldosterone excess.",

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Aldosterone secretion and action. / Fuller, Peter J ; Young, Morag J.
Endocrinology: Adult and Pediatric. ed. / J Larry Jameson; Leslie J De Groot; David M de Kretser; Linda C Giudice; Ashley B Grossman; Shlomo Melmed; John T Potts Jr; Gordon C Weir. Vol. 2 7th. ed. Philadelphia PA USA: Elsevier, 2016. p. 1756-1762.

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review

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T1 - Aldosterone secretion and action

AU - Fuller, Peter J

AU - Young, Morag J

PY - 2016

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N2 - Aldosterone activates the mineralocorticoid receptor (MR), a member of the nuclear receptor superfamily. Aldosterone synthesis/secretion is primarily regulated by angiotensin II nd potassium as part of two parallel feedback loops. The MR is unique, being the receptor for two physiologic ligands: aldosterone and cortisol. Aldosterone selectivity of the MR in epithelial tissues is conferred by 11 hydroxysteroid dehydrogenase type II. Activation of the MR in nonepithelial tissue is associated with a proinflammatory, profibrotic response connected with the adverse cardiovascular outcome, seen with aldosterone excess.

AB - Aldosterone activates the mineralocorticoid receptor (MR), a member of the nuclear receptor superfamily. Aldosterone synthesis/secretion is primarily regulated by angiotensin II nd potassium as part of two parallel feedback loops. The MR is unique, being the receptor for two physiologic ligands: aldosterone and cortisol. Aldosterone selectivity of the MR in epithelial tissues is conferred by 11 hydroxysteroid dehydrogenase type II. Activation of the MR in nonepithelial tissue is associated with a proinflammatory, profibrotic response connected with the adverse cardiovascular outcome, seen with aldosterone excess.

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SN - 9780323189071

VL - 2

SP - 1756

EP - 1762

BT - Endocrinology

A2 - Jameson, J Larry

A2 - De Groot, Leslie J

A2 - de Kretser, David M

A2 - Giudice, Linda C

A2 - Grossman, Ashley B

A2 - Melmed, Shlomo

A2 - Potts Jr, John T

A2 - Weir, Gordon C

PB - Elsevier

CY - Philadelphia PA USA

ER -

Aldosterone secretion and action

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