Aldosterone activates the mineralocorticoid receptor (MR), a member of the nuclear receptor superfamily. Aldosterone synthesis/secretion is primarily regulated by angiotensin II nd potassium as part of two parallel feedback loops. The MR is unique, being the receptor for two physiologic ligands: aldosterone and cortisol. Aldosterone selectivity of the MR in epithelial tissues is conferred by 11 hydroxysteroid dehydrogenase type II. Activation of the MR in nonepithelial tissue is associated with a proinflammatory, profibrotic response connected with the adverse cardiovascular outcome, seen with aldosterone excess.
|Title of host publication||Endocrinology|
|Subtitle of host publication||Adult and Pediatric|
|Editors||J Larry Jameson, Leslie J De Groot, David M de Kretser, Linda C Giudice, Ashley B Grossman, Shlomo Melmed, John T Potts Jr, Gordon C Weir|
|Place of Publication||Philadelphia PA USA|
|Number of pages||7|
|Publication status||Published - 2016|