Aldosterone activates the mineralocorticoid receptor (MR), a member of the nuclear receptor superfamily. Aldosterone synthesis/secretion is primarily regulated by angiotensin II nd potassium as part of two parallel feedback loops. The MR is unique, being the receptor for two physiologic ligands: aldosterone and cortisol. Aldosterone selectivity of the MR in epithelial tissues is conferred by 11 hydroxysteroid dehydrogenase type II. Activation of the MR in nonepithelial tissue is associated with a proinflammatory, profibrotic response connected with the adverse cardiovascular outcome, seen with aldosterone excess.
|Title of host publication||Endocrinology|
|Subtitle of host publication||Adult and Pediatric|
|Editors||J Larry Jameson, Leslie J De Groot, David M de Kretser, Linda C Giudice, Ashley B Grossman, Shlomo Melmed, John T Potts Jr, Gordon C Weir|
|Place of Publication||Philadelphia PA USA|
|Number of pages||7|
|Publication status||Published - 2016|
Fuller, P. J., & Young, M. J. (2016). Aldosterone secretion and action. In J. L. Jameson, L. J. De Groot, D. M. de Kretser, L. C. Giudice, A. B. Grossman, S. Melmed, J. T. Potts Jr, & G. C. Weir (Eds.), Endocrinology: Adult and Pediatric (7th ed., Vol. 2, pp. 1756-1762). Elsevier. https://doi.org/10.1016/B978-0-323-18907-1.00101-3