Aldosterone secretion and action

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Abstract

Aldosterone activates the mineralocorticoid receptor (MR), a member of the nuclear receptor superfamily. Aldosterone synthesis/secretion is primarily regulated by angiotensin II nd potassium as part of two parallel feedback loops. The MR is unique, being the receptor for two physiologic ligands: aldosterone and cortisol. Aldosterone selectivity of the MR in epithelial tissues is conferred by 11 hydroxysteroid dehydrogenase type II. Activation of the MR in nonepithelial tissue is associated with a proinflammatory, profibrotic response connected with the adverse cardiovascular outcome, seen with aldosterone excess.
Original languageEnglish
Title of host publicationEndocrinology
Subtitle of host publicationAdult and Pediatric
EditorsJ Larry Jameson, Leslie J De Groot, David M de Kretser, Linda C Giudice, Ashley B Grossman, Shlomo Melmed, John T Potts Jr, Gordon C Weir
Place of PublicationPhiladelphia PA USA
PublisherElsevier
Pages1756-1762
Number of pages7
Volume2
Edition7th
ISBN (Print)9780323189071
DOIs
Publication statusPublished - 2016

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