Aldosterone and the heart

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

Classically, aldosterone is a steroid hormone secreted from the adrenal cortex, which acts on kidney, colon and sweat/salivary glands to promote unidirectional sodium transport. Currently, there is excellent experimental evidence for aldosterone acting directly on the central nervous system to raise blood pressure, and on the heart to cause cardiac hypertrophy and fibrosis. In addition, there is emerging evidence for aldosterone synthesis in the heart, and for as yet unexplained benefits of aldosterone antagonism in the treatment of cardiac failure.

Original languageEnglish
Pages (from-to)224-226
Number of pages3
JournalTrends in Endocrinology and Metabolism
Volume11
Issue number6
DOIs
Publication statusPublished - 1 Aug 2000
Externally publishedYes

Cite this

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abstract = "Classically, aldosterone is a steroid hormone secreted from the adrenal cortex, which acts on kidney, colon and sweat/salivary glands to promote unidirectional sodium transport. Currently, there is excellent experimental evidence for aldosterone acting directly on the central nervous system to raise blood pressure, and on the heart to cause cardiac hypertrophy and fibrosis. In addition, there is emerging evidence for aldosterone synthesis in the heart, and for as yet unexplained benefits of aldosterone antagonism in the treatment of cardiac failure.",
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Aldosterone and the heart. / Young, Morag; Funder, John W.

In: Trends in Endocrinology and Metabolism, Vol. 11, No. 6, 01.08.2000, p. 224-226.

Research output: Contribution to journalReview ArticleResearchpeer-review

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N2 - Classically, aldosterone is a steroid hormone secreted from the adrenal cortex, which acts on kidney, colon and sweat/salivary glands to promote unidirectional sodium transport. Currently, there is excellent experimental evidence for aldosterone acting directly on the central nervous system to raise blood pressure, and on the heart to cause cardiac hypertrophy and fibrosis. In addition, there is emerging evidence for aldosterone synthesis in the heart, and for as yet unexplained benefits of aldosterone antagonism in the treatment of cardiac failure.

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