Aldosterone and Mineralocorticoid Receptors

J. W. Funder

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

1 Citation (Scopus)


Physiologically, aldosterone is a homeostatic hormone, rising in response to sodium deficiency, potassium loading, and volume depletion to restore the status quo ante: it is also raised acutely but not chronically by adrenocorticotropic hormone (ACTH). Pathophysiologically, in primary aldosteronism (PA) aldosterone levels are inappropriately high for the subject's sodium/potassium/volume status, thus outside the normal feedback loop, and no longer homeostatic but causing widespread deleterious cardiovascular effects. Long thought to be a rare and relatively benign form of hypertension, patients with PA have much higher risk factors for cardiovascular disease than age-, sex-, and BP-matched essential hypertensives. The role of ACTH in aldosterone secretion has not received major attention, although recent studies suggest a major involvement in stress-related rather than homeostatic secretion, playing an additional, as yet unrecognized, causative role in PA.

Original languageEnglish
Title of host publicationStress
Subtitle of host publicationNeuroendocrinology and Neurobiology
EditorsGeorge Fink
Place of PublicationLondon UK
PublisherAcademic Press
Number of pages5
ISBN (Electronic)9780128024232
ISBN (Print)9780128021750
Publication statusPublished - 2017

Publication series

NameHandbook of Stress Series


  • Adrenocorticotropic hormone
  • Cortisol
  • Hypertensive
  • Minerelocorticoid receptor
  • Primary aldosteronism
  • Transcortin

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