Aldosterone and its mechanism of action: More questions than answers

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Abstract

The physiology of the steroid hormone, aldosterone is well defined. The molecular events that mediate this response remain to be elucidated. Aldosterone binds to a specific mineralocorlicoid receptor (MR) in sodium transporting epithelia. The structural determinants of ligand-binding have been explored through the analysis of steroid resistance syndromes, however, the molecular basis of resistance to aldosterone, pseudohypoaldosteronism remains an enigma. Cortisol also binds MR, access is however restricted by the enzyme 11β-hydroxysteroid dehydrogenase. The MR induces specific genes which regulate apical amiloride-sensitive epithelial sodium channels; the finding of activating mutations in Liddles syndrome (pseudoaldosteronism) has emphasised their key role. Such mechanisms may apply not only to the peripheral effects of aldosterone but also to the central regulation of blood pressure.

Original languageEnglish
Pages (from-to)800-807
Number of pages8
JournalAustralian and New Zealand Journal of Medicine
Volume25
Issue number6
Publication statusPublished - 1995
Externally publishedYes

Keywords

  • Aldosterone
  • Cortisol
  • Hypertension
  • Receptors

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