Aldosterone and DNA: The 50th anniversary

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Abstract

Fifty years ago, in 1953, both the steroid hormone aldosterone and the structure of DNA were isolated. This last discovery allowed the technologies of molecular biology to elucidate the mechanism by which aldosterone regulates epithelial Na+ transport. The occasion of the meeting 'Hormones and the Heart', held in Melbourne in September 2003, provides an opportunity to review recent work on the structural determinants of binding specificity in the corticosteroid receptors and on the characterization of the genes involved in mediating the response to aldosterone.

Original languageEnglish
Pages (from-to)143-146
Number of pages4
JournalTrends in Endocrinology & Metabolism
Volume15
Issue number4
DOIs
Publication statusPublished - May 2004
Externally publishedYes

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