Albumin resuscitation for traumatic brain injury: is intracranial hypertension the cause of increased mortality?

David James Cooper, John Myburgh, Stephane Heritier, Simon Finfer, Rinaldo Bellomo, Laurent Billot, Lynnette Joy Murray, Shirley Vallance

Research output: Contribution to journalArticleResearchpeer-review

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Abstract

Mortality is higher in patients with traumatic brain injury (TBI) resuscitated with albumin compared to saline, but the mechanism for increased mortality is unknown. In patients from the Saline vs. Albumin Fluid Evaluation (SAFE) study with TBI who underwent ICP monitoring, interventional data were collected from randomization to day 14 to determine changes in ICP (primary outcome) and in therapies used to treat increased ICP. Pattern mixture modelling, designed to address informative dropouts, was used to compare temporal changes between the albumin and saline groups. 321 patients were identified, of whom 164 (51.1 ) received albumin and 157 (48.9 ) saline. There was a significant linear increase in mean ICP and significantly more deaths in the albumin group compared to saline when ICP monitoring was ceased during the first week (1.30?0.33 vs. -0.37?0.36, p=0.0006; and 34.4 vs. 17.4 ; p=0.006 respectively), but not when monitoring ceased during the second week (-0.08?0.44 vs. -0.23?0.38, p=0.79; and 18.6 vs. 12.1 ; p=0.36 respectively). There were statistically significant differences in the mean total daily doses of morphine (-0.42?0.07 vs. -0.66?0.0, p=0.0009), propofol (-0.45?0.11 vs. -0.76?0.11; p=0.034) and norepinephrine (-0.50?0.07 vs. -0.74?0.07) and in temperature (0.03 ? 0.03 vs. 0.16 ? 0.03; p=0.0014) between the albumin and saline groups when ICP monitoring ceased during the first week. The use of albumin for resuscitation in patients with severe TBI is associated with increased ICP during the first week. This is the most likely mechanism of increased mortality in these patients.
Original languageEnglish
Pages (from-to)512 - 518
Number of pages7
JournalJournal of Neurotrauma
Volume30
Issue number7
DOIs
Publication statusPublished - 2013

Cite this

@article{3d9569ef33d14f618ebcc15d457612c7,
title = "Albumin resuscitation for traumatic brain injury: is intracranial hypertension the cause of increased mortality?",
abstract = "Mortality is higher in patients with traumatic brain injury (TBI) resuscitated with albumin compared to saline, but the mechanism for increased mortality is unknown. In patients from the Saline vs. Albumin Fluid Evaluation (SAFE) study with TBI who underwent ICP monitoring, interventional data were collected from randomization to day 14 to determine changes in ICP (primary outcome) and in therapies used to treat increased ICP. Pattern mixture modelling, designed to address informative dropouts, was used to compare temporal changes between the albumin and saline groups. 321 patients were identified, of whom 164 (51.1 ) received albumin and 157 (48.9 ) saline. There was a significant linear increase in mean ICP and significantly more deaths in the albumin group compared to saline when ICP monitoring was ceased during the first week (1.30?0.33 vs. -0.37?0.36, p=0.0006; and 34.4 vs. 17.4 ; p=0.006 respectively), but not when monitoring ceased during the second week (-0.08?0.44 vs. -0.23?0.38, p=0.79; and 18.6 vs. 12.1 ; p=0.36 respectively). There were statistically significant differences in the mean total daily doses of morphine (-0.42?0.07 vs. -0.66?0.0, p=0.0009), propofol (-0.45?0.11 vs. -0.76?0.11; p=0.034) and norepinephrine (-0.50?0.07 vs. -0.74?0.07) and in temperature (0.03 ? 0.03 vs. 0.16 ? 0.03; p=0.0014) between the albumin and saline groups when ICP monitoring ceased during the first week. The use of albumin for resuscitation in patients with severe TBI is associated with increased ICP during the first week. This is the most likely mechanism of increased mortality in these patients.",
author = "Cooper, {David James} and John Myburgh and Stephane Heritier and Simon Finfer and Rinaldo Bellomo and Laurent Billot and Murray, {Lynnette Joy} and Shirley Vallance",
year = "2013",
doi = "10.1089/neu.2012.2573",
language = "English",
volume = "30",
pages = "512 -- 518",
journal = "Journal of Neurotrauma",
issn = "0897-7151",
publisher = "Mary Ann Liebert Inc",
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Albumin resuscitation for traumatic brain injury: is intracranial hypertension the cause of increased mortality? / Cooper, David James; Myburgh, John; Heritier, Stephane; Finfer, Simon; Bellomo, Rinaldo; Billot, Laurent; Murray, Lynnette Joy; Vallance, Shirley.

In: Journal of Neurotrauma, Vol. 30, No. 7, 2013, p. 512 - 518.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Albumin resuscitation for traumatic brain injury: is intracranial hypertension the cause of increased mortality?

AU - Cooper, David James

AU - Myburgh, John

AU - Heritier, Stephane

AU - Finfer, Simon

AU - Bellomo, Rinaldo

AU - Billot, Laurent

AU - Murray, Lynnette Joy

AU - Vallance, Shirley

PY - 2013

Y1 - 2013

N2 - Mortality is higher in patients with traumatic brain injury (TBI) resuscitated with albumin compared to saline, but the mechanism for increased mortality is unknown. In patients from the Saline vs. Albumin Fluid Evaluation (SAFE) study with TBI who underwent ICP monitoring, interventional data were collected from randomization to day 14 to determine changes in ICP (primary outcome) and in therapies used to treat increased ICP. Pattern mixture modelling, designed to address informative dropouts, was used to compare temporal changes between the albumin and saline groups. 321 patients were identified, of whom 164 (51.1 ) received albumin and 157 (48.9 ) saline. There was a significant linear increase in mean ICP and significantly more deaths in the albumin group compared to saline when ICP monitoring was ceased during the first week (1.30?0.33 vs. -0.37?0.36, p=0.0006; and 34.4 vs. 17.4 ; p=0.006 respectively), but not when monitoring ceased during the second week (-0.08?0.44 vs. -0.23?0.38, p=0.79; and 18.6 vs. 12.1 ; p=0.36 respectively). There were statistically significant differences in the mean total daily doses of morphine (-0.42?0.07 vs. -0.66?0.0, p=0.0009), propofol (-0.45?0.11 vs. -0.76?0.11; p=0.034) and norepinephrine (-0.50?0.07 vs. -0.74?0.07) and in temperature (0.03 ? 0.03 vs. 0.16 ? 0.03; p=0.0014) between the albumin and saline groups when ICP monitoring ceased during the first week. The use of albumin for resuscitation in patients with severe TBI is associated with increased ICP during the first week. This is the most likely mechanism of increased mortality in these patients.

AB - Mortality is higher in patients with traumatic brain injury (TBI) resuscitated with albumin compared to saline, but the mechanism for increased mortality is unknown. In patients from the Saline vs. Albumin Fluid Evaluation (SAFE) study with TBI who underwent ICP monitoring, interventional data were collected from randomization to day 14 to determine changes in ICP (primary outcome) and in therapies used to treat increased ICP. Pattern mixture modelling, designed to address informative dropouts, was used to compare temporal changes between the albumin and saline groups. 321 patients were identified, of whom 164 (51.1 ) received albumin and 157 (48.9 ) saline. There was a significant linear increase in mean ICP and significantly more deaths in the albumin group compared to saline when ICP monitoring was ceased during the first week (1.30?0.33 vs. -0.37?0.36, p=0.0006; and 34.4 vs. 17.4 ; p=0.006 respectively), but not when monitoring ceased during the second week (-0.08?0.44 vs. -0.23?0.38, p=0.79; and 18.6 vs. 12.1 ; p=0.36 respectively). There were statistically significant differences in the mean total daily doses of morphine (-0.42?0.07 vs. -0.66?0.0, p=0.0009), propofol (-0.45?0.11 vs. -0.76?0.11; p=0.034) and norepinephrine (-0.50?0.07 vs. -0.74?0.07) and in temperature (0.03 ? 0.03 vs. 0.16 ? 0.03; p=0.0014) between the albumin and saline groups when ICP monitoring ceased during the first week. The use of albumin for resuscitation in patients with severe TBI is associated with increased ICP during the first week. This is the most likely mechanism of increased mortality in these patients.

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DO - 10.1089/neu.2012.2573

M3 - Article

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EP - 518

JO - Journal of Neurotrauma

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