TY - JOUR
T1 - Airway bypass improves the mechanical properties of explanted emphysematous lungs
AU - Choong, Cliff Khuat Chye
AU - Macklem, Peter T
AU - Pierce, John A
AU - Das, Nitin
AU - Lutey, Barbara A
AU - Martinez, Carlo O
AU - Cooper, Joel
PY - 2008
Y1 - 2008
N2 - RATIONALE: By creating artificial communications through bronchial walls into the parenchyma of explanted lungs (airway bypass), we expect to decrease the amount of gas trapped and to increase the rate and volume of air expelled during forced expirations. OBJECTIVES: To describe the mechanism by which airway bypass improves the mechanical properties of the emphysematous lung. METHODS: Lung compartments and mechanics were measured before and after airway bypass, which was created by placement of three or four stent-supported fenestrations in 10 emphysematous lungs removed at transplantation surgery. MEASUREMENTS AND MAIN RESULTS: Minimal volume after passive deflation decreased by a mean of 1.54 L (range, 0.7-2.5 L) or 60 (range, 37-86 ). Explanted VC increased by 1.30 L or 132 (range, 78-318 ). Maximal expiratory flows and volumes increased. Flow resistance decreased.
AB - RATIONALE: By creating artificial communications through bronchial walls into the parenchyma of explanted lungs (airway bypass), we expect to decrease the amount of gas trapped and to increase the rate and volume of air expelled during forced expirations. OBJECTIVES: To describe the mechanism by which airway bypass improves the mechanical properties of the emphysematous lung. METHODS: Lung compartments and mechanics were measured before and after airway bypass, which was created by placement of three or four stent-supported fenestrations in 10 emphysematous lungs removed at transplantation surgery. MEASUREMENTS AND MAIN RESULTS: Minimal volume after passive deflation decreased by a mean of 1.54 L (range, 0.7-2.5 L) or 60 (range, 37-86 ). Explanted VC increased by 1.30 L or 132 (range, 78-318 ). Maximal expiratory flows and volumes increased. Flow resistance decreased.
UR - http://ajrccm.atsjournals.org/cgi/reprint/178/9/902
U2 - 10.1164/rccm.200712-1832OC
DO - 10.1164/rccm.200712-1832OC
M3 - Article
SN - 1073-449X
VL - 178
SP - 902
EP - 905
JO - American Journal of Respiratory and Critical Care Medicine
JF - American Journal of Respiratory and Critical Care Medicine
IS - 9
ER -