Airway bypass improves the mechanical properties of explanted emphysematous lungs

Cliff Khuat Chye Choong, Peter T Macklem, John A Pierce, Nitin Das, Barbara A Lutey, Carlos O Martinez, Joel Cooper

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47 Citations (Scopus)


RATIONALE: By creating artificial communications through bronchial walls into the parenchyma of explanted lungs (airway bypass), we expect to decrease the amount of gas trapped and to increase the rate and volume of air expelled during forced expirations. OBJECTIVES: To describe the mechanism by which airway bypass improves the mechanical properties of the emphysematous lung. METHODS: Lung compartments and mechanics were measured before and after airway bypass, which was created by placement of three or four stent-supported fenestrations in 10 emphysematous lungs removed at transplantation surgery. MEASUREMENTS AND MAIN RESULTS: Minimal volume after passive deflation decreased by a mean of 1.54 L (range, 0.7-2.5 L) or 60 (range, 37-86 ). Explanted VC increased by 1.30 L or 132 (range, 78-318 ). Maximal expiratory flows and volumes increased. Flow resistance decreased.
Original languageEnglish
Pages (from-to)902 - 905
Number of pages4
JournalAmerican Journal of Respiratory and Critical Care Medicine
Issue number9
Publication statusPublished - 2008

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