Abstract
Recent findings by Felton et al. and Qiu et al. unveil the importance of the transcription factor Aiolos for tissue-resident eosinophils
and group 2 innate lymphoid cells (ILC2s). The authors find that Aiolos regulates the transcriptomic profile and chromatin
landscape, both of which are essential for eosinophil and ILC2 localisation in tissues, as well as their function. These studies place
Aiolos as a molecular guardian that regulates tissue-resident type 2 innate cells.
and group 2 innate lymphoid cells (ILC2s). The authors find that Aiolos regulates the transcriptomic profile and chromatin
landscape, both of which are essential for eosinophil and ILC2 localisation in tissues, as well as their function. These studies place
Aiolos as a molecular guardian that regulates tissue-resident type 2 innate cells.
Original language | English |
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Pages (from-to) | 1221-1223 |
Number of pages | 3 |
Journal | Mucosal Immunology |
Volume | 14 |
Issue number | 6 |
DOIs |
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Publication status | Published - Nov 2021 |