Aiolos: a molecular guardian of type 2 innate immune cell residency and response

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3 Citations (Scopus)

Abstract

Recent findings by Felton et al. and Qiu et al. unveil the importance of the transcription factor Aiolos for tissue-resident eosinophils
and group 2 innate lymphoid cells (ILC2s). The authors find that Aiolos regulates the transcriptomic profile and chromatin
landscape, both of which are essential for eosinophil and ILC2 localisation in tissues, as well as their function. These studies place
Aiolos as a molecular guardian that regulates tissue-resident type 2 innate cells.
Original languageEnglish
Pages (from-to)1221-1223
Number of pages3
JournalMucosal Immunology
Volume14
Issue number6
DOIs
Publication statusPublished - Nov 2021

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