TY - JOUR
T1 - A Shigella sonnei clone with extensive drug resistance associated with waterborne outbreaks in China
AU - Qiu, Shaofu
AU - Liu, Kangkang
AU - Yang, Chaojie
AU - Xiang, Ying
AU - Min, Kaiyuan
AU - Zhu, Kunpeng
AU - Liu, Hongbo
AU - Du, Xinying
AU - Yang, Mingjuan
AU - Wang, Ligui
AU - Sun, Yong
AU - Zhou, Haijian
AU - Mahe, Muti
AU - Zhao, Jiayong
AU - Li, Shijun
AU - Yu, Deshan
AU - Hawkey, Jane
AU - Holt, Kathryn E.
AU - Baker, Stephen
AU - Yang, Juntao
AU - Xu, Xuebin
AU - Song, Hongbin
N1 - Funding Information:
This work was funded by the National Key R&D Program of China (grant number 2017YFC1600100 to S.Q.), the National Key Program for Infectious Diseases of China (no. 2012ZX10004215 to S.Q.), the National Nature Science Foundation of China (nos. 82173580 and 81872678 to S.Q.), and the Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences (2021-I2M-1-044 to J.Y.). The funders had no role in the study design, data collection, data analysis, data interpretation, or writing of the report.
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Antimicrobial resistance of Shigella sonnei has become a global concern. Here, we report a phylogenetic group of S. sonnei with extensive drug resistance, including a combination of multidrug resistance, coresistance to ceftriaxone and azithromycin (cefRaziR), reduced susceptibility to fluoroquinolones, and even colistin resistance (colR). This distinct clone caused six waterborne shigellosis outbreaks in China from 2015 to 2020. We collect 155 outbreak isolates and 152 sporadic isolates. The cefRaziR isolates, including outbreak strains, are mainly distributed in a distinct clade located in global Lineage III. The outbreak strains form a recently derived monophyletic group that may have emerged circa 2010. The cefRaziR and colR phenotypes are attributed to the acquisition of different plasmids, particularly the IncB/O/K/Z plasmid coharboring the blaCTX-M-14, mphA, aac(3)-IId, dfrA17, aadA5, and sul1 genes and the IncI2 plasmid with an mcr-1 gene. Genetic analyses identify 92 accessory genes and 60 single-nucleotide polymorphisms associated with the cefRaziR phenotype. Surveillance of this clone is required to determine its dissemination and threat to global public health.
AB - Antimicrobial resistance of Shigella sonnei has become a global concern. Here, we report a phylogenetic group of S. sonnei with extensive drug resistance, including a combination of multidrug resistance, coresistance to ceftriaxone and azithromycin (cefRaziR), reduced susceptibility to fluoroquinolones, and even colistin resistance (colR). This distinct clone caused six waterborne shigellosis outbreaks in China from 2015 to 2020. We collect 155 outbreak isolates and 152 sporadic isolates. The cefRaziR isolates, including outbreak strains, are mainly distributed in a distinct clade located in global Lineage III. The outbreak strains form a recently derived monophyletic group that may have emerged circa 2010. The cefRaziR and colR phenotypes are attributed to the acquisition of different plasmids, particularly the IncB/O/K/Z plasmid coharboring the blaCTX-M-14, mphA, aac(3)-IId, dfrA17, aadA5, and sul1 genes and the IncI2 plasmid with an mcr-1 gene. Genetic analyses identify 92 accessory genes and 60 single-nucleotide polymorphisms associated with the cefRaziR phenotype. Surveillance of this clone is required to determine its dissemination and threat to global public health.
UR - http://www.scopus.com/inward/record.url?scp=85143089304&partnerID=8YFLogxK
U2 - 10.1038/s41467-022-35136-1
DO - 10.1038/s41467-022-35136-1
M3 - Article
C2 - 36450777
AN - SCOPUS:85143089304
SN - 2041-1723
VL - 13
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 7365
ER -
