Agonist-biased trafficking of somatostatin receptor 2A in enteric neurons

Peishen Zhao; Meritxell Canals; Jane E Murphy; Diana Klingler; Emily M Eriksson; Juan-Carlos Pelayo; Markus Hardt; Nigel William Bunnett; Daniel Philip Poole

doi:10.1074/jbc.M113.496414

Agonist-biased trafficking of somatostatin receptor 2A in enteric neurons

Peishen Zhao, Meritxell Canals, Jane E Murphy, Diana Klingler, Emily M Eriksson, Juan-Carlos Pelayo, Markus Hardt, Nigel William Bunnett, Daniel Philip Poole

Drug Discovery Biology

Research output: Contribution to journal › Article › Research › peer-review

32 Citations (Scopus)

Abstract

Background: Somatostatin regulates gut function via neuronal somatostatin receptors. Results: Somatostatin susceptibility to degradation by endosomal endothelin-converting enzyme 1 (ECE-1) defines receptor function. Conclusion: ECE-1 regulates the duration of somatostatin receptor signaling and trafficking. Significance: Therapeutic somatostatin analogs are ECE-1-resistant, which underlies their prolonged actions.

Original language	English
Pages (from-to)	25689 - 25700
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	288
Issue number	36
DOIs	https://doi.org/10.1074/jbc.M113.496414
Publication status	Published - 2013

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title = "Agonist-biased trafficking of somatostatin receptor 2A in enteric neurons",

abstract = "Background: Somatostatin regulates gut function via neuronal somatostatin receptors. Results: Somatostatin susceptibility to degradation by endosomal endothelin-converting enzyme 1 (ECE-1) defines receptor function. Conclusion: ECE-1 regulates the duration of somatostatin receptor signaling and trafficking. Significance: Therapeutic somatostatin analogs are ECE-1-resistant, which underlies their prolonged actions.",

author = "Peishen Zhao and Meritxell Canals and Murphy, {Jane E} and Diana Klingler and Eriksson, {Emily M} and Juan-Carlos Pelayo and Markus Hardt and Bunnett, {Nigel William} and Poole, {Daniel Philip}",

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T1 - Agonist-biased trafficking of somatostatin receptor 2A in enteric neurons

AU - Zhao, Peishen

AU - Canals, Meritxell

AU - Murphy, Jane E

AU - Klingler, Diana

AU - Eriksson, Emily M

AU - Pelayo, Juan-Carlos

AU - Hardt, Markus

AU - Bunnett, Nigel William

AU - Poole, Daniel Philip

PY - 2013

Y1 - 2013

N2 - Background: Somatostatin regulates gut function via neuronal somatostatin receptors. Results: Somatostatin susceptibility to degradation by endosomal endothelin-converting enzyme 1 (ECE-1) defines receptor function. Conclusion: ECE-1 regulates the duration of somatostatin receptor signaling and trafficking. Significance: Therapeutic somatostatin analogs are ECE-1-resistant, which underlies their prolonged actions.

AB - Background: Somatostatin regulates gut function via neuronal somatostatin receptors. Results: Somatostatin susceptibility to degradation by endosomal endothelin-converting enzyme 1 (ECE-1) defines receptor function. Conclusion: ECE-1 regulates the duration of somatostatin receptor signaling and trafficking. Significance: Therapeutic somatostatin analogs are ECE-1-resistant, which underlies their prolonged actions.

UR - http://www.jbc.org/content/288/36/25689

U2 - 10.1074/jbc.M113.496414

DO - 10.1074/jbc.M113.496414

M3 - Article

SN - 0021-9258

VL - 288

SP - 25689

EP - 25700

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 36

ER -

Agonist-biased trafficking of somatostatin receptor 2A in enteric neurons

Abstract

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