Agonist-biased trafficking of somatostatin receptor 2A in enteric neurons

Peishen Zhao, Meritxell Canals, Jane E Murphy, Diana Klingler, Emily M Eriksson, Juan-Carlos Pelayo, Markus Hardt, Nigel William Bunnett, Daniel Philip Poole

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

Abstract

Background: Somatostatin regulates gut function via neuronal somatostatin receptors. Results: Somatostatin susceptibility to degradation by endosomal endothelin-converting enzyme 1 (ECE-1) defines receptor function. Conclusion: ECE-1 regulates the duration of somatostatin receptor signaling and trafficking. Significance: Therapeutic somatostatin analogs are ECE-1-resistant, which underlies their prolonged actions.
Original languageEnglish
Pages (from-to)25689 - 25700
Number of pages12
JournalJournal of Biological Chemistry
Volume288
Issue number36
DOIs
Publication statusPublished - 2013

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