Aging of intestinal stem cells and associated niche

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Abstract

Intestinal stem cells are responsible for the extremely rapid renewal of the entire epithelial lining. The maintenance of the critical absorptive function of the gut relies on the appropriate control of the stem cell pool by the local micro-environment or niche cells. Aging causes dramatic changes in the local regulation of stem cells and alters their function, resulting in absorptive defects and development of diseases. Mechanistically, aging induces both profound cellular and molecular intrinsic alterations of the stem cell pool and mediates aberrant behavior of their associated niche cells. Importantly, some of these identified changes can be therapeutically targeted, which offers the possibility to restore gut function in aging.
Original languageEnglish
Title of host publicationAdvances in Stem Cells and their Niches
Subtitle of host publicationThe Stem Cell Niche during Ageing
EditorsSusie Nilsson
Place of PublicationCambridge, USA
PublisherAcademic Press
Chapter2
Pages25-40
Number of pages16
ISBN (Print)9780128220191
DOIs
Publication statusPublished - 2020

Publication series

NameAdvances in Stem Cells and their Niches
PublisherElsevier
Volume4
ISSN (Print)2468-5097

Keywords

  • aging
  • intestinal stem cells
  • niche
  • paneth cells
  • WNT singaling
  • mTORC1 signaling
  • tissue regeneration

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