Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function

Anna Clare Hearps, Genevieve Martin, Thomas A Angelovich, Wan-Jung Cheng, Anna Maisa, Alan L Landay, Anthony Jaworowski, Suzanne Mary Crowe

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Abstract

In a cross-sectional study involving 91 healthy male (aged 20?84 years, median 52.4) and 55 female (aged 20? 82 years, median 48.3) individuals, we found age was associated with an increased proportion of intermediate and nonclassical monocytes (P = 0.002 and 0.04, respectively) and altered phenotype of specific monocyte subsets (e.g. increased expression of CD11b and decreased expression of CD38, CD62L and CD115).
Original languageEnglish
Pages (from-to)867 - 875
Number of pages9
JournalAging Cell
Volume11
Issue number5
DOIs
Publication statusPublished - 2012

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