Aggregation by platelets from pregnant zinc deficient rats

K. R. West, I. E. Dreosti, Caroline Eve Gargett, I. Record

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Aggregation by rat platelets, which have been reported to respond poorly to ADP and collagen, was found to be significantly improved if calcium was added to platelets prior to challenge with the aggregating agent. Zinc deficiency, sufficient to induce bleeding in pregnant rats, did not reduce the ability of platelets to aggregate, or to release serotonin, compared with ad libitum fed control animals. The data do not suggest that prolonged bleeding in zinc deficient rats during parturition arises from reduced platelet aggregation. However, platelets isolated from the blood of pair fed animals which were supplemented with zinc, showed significantly increased aggregability.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalNutrition Reports International
Issue number1
Publication statusPublished - 1 Jan 1980
Externally publishedYes

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