TY - JOUR
T1 - Agglomerate strength and dispersion of pharmaceutical powders
AU - Adi, Santoso
AU - Adi, Handoko
AU - Chan, Hak-Kim
AU - Finlay, Warren H
AU - Tong, Zhenbo
AU - Yang, Runyu
AU - Yu, Aibing
PY - 2011
Y1 - 2011
N2 - This study aims to investigate quantitatively the direct correlation between the mechanical strength of powder agglomerates and their dispersion into aerosols by a dry powder inhaler. Agglomerates of mannitol as a model drug-only formulation were prepared by a rolling method followed by exposure to various relative humidity (RH: 55 , 82 , 86 and 90 ). The agglomerate strength was obtained from the compression of single agglomerates at a selected speed rate using an Instron testing machine. The dispersion performance (FPFLoaded) was determined at flow rates of 60 and 100lmin-1 using an Aeroliser? coupled to a multistage liquid impinger. Results showed an inverse linear relationship between the agglomerate strength and the dispersion performance. An increase in strength from 3 to 183kPa resulted in a significant drop (P
AB - This study aims to investigate quantitatively the direct correlation between the mechanical strength of powder agglomerates and their dispersion into aerosols by a dry powder inhaler. Agglomerates of mannitol as a model drug-only formulation were prepared by a rolling method followed by exposure to various relative humidity (RH: 55 , 82 , 86 and 90 ). The agglomerate strength was obtained from the compression of single agglomerates at a selected speed rate using an Instron testing machine. The dispersion performance (FPFLoaded) was determined at flow rates of 60 and 100lmin-1 using an Aeroliser? coupled to a multistage liquid impinger. Results showed an inverse linear relationship between the agglomerate strength and the dispersion performance. An increase in strength from 3 to 183kPa resulted in a significant drop (P
UR - http://goo.gl/UoN6gr
U2 - 10.1016/j.jaerosci.2011.02.002
DO - 10.1016/j.jaerosci.2011.02.002
M3 - Article
SN - 0021-8502
VL - 42
SP - 285
EP - 294
JO - Journal of Aerosol Science
JF - Journal of Aerosol Science
IS - 4
ER -