Agents of last resort: polymyxin resistance

Keith S. Kaye, Jason M. Pogue, Thien B Tran, Roger L Nation, Jian Li

Research output: Contribution to journalReview ArticleResearchpeer-review

137 Citations (Scopus)


Polymyxin resistance is a major public health threat, as the polymyxins represent “last-line” therapeutics for Gram-negative pathogens resistant to essentially all other antibiotics. Improved understanding of mechanisms of, and risk factors for, polymyxin resistance, as well as infection prevention and stewardship strategies, together with optimization of dosing of polymyxins including in combination regimens, can help to limit the emergence and dissemination of polymyxin resistance.

Original languageEnglish
Pages (from-to)391-414
Number of pages24
JournalInfectious Disease Clinics of North America
Issue number2
Publication statusPublished - 1 Jun 2016


  • Colistin
  • Gram-negative
  • Polymyxin B
  • Polymyxins
  • Resistance

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