Agents of last resort: polymyxin resistance

Keith S. Kaye; Jason M. Pogue; Thien B Tran; Roger L Nation; Jian Li

doi:10.1016/j.idc.2016.02.005

Agents of last resort: polymyxin resistance

Keith S. Kaye, Jason M. Pogue, Thien B Tran, Roger L Nation, Jian Li

Drug Delivery Disposition & Dynamics

Research output: Contribution to journal › Review Article › Research › peer-review

151 Citations (Scopus)

Abstract

Polymyxin resistance is a major public health threat, as the polymyxins represent “last-line” therapeutics for Gram-negative pathogens resistant to essentially all other antibiotics. Improved understanding of mechanisms of, and risk factors for, polymyxin resistance, as well as infection prevention and stewardship strategies, together with optimization of dosing of polymyxins including in combination regimens, can help to limit the emergence and dissemination of polymyxin resistance.

Original language	English
Pages (from-to)	391-414
Number of pages	24
Journal	Infectious Disease Clinics of North America
Volume	30
Issue number	2
DOIs	https://doi.org/10.1016/j.idc.2016.02.005
Publication status	Published - 1 Jun 2016

Keywords

Colistin
Gram-negative
Polymyxin B
Polymyxins
Resistance

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.idc.2016.02.005

Cite this

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title = "Agents of last resort: polymyxin resistance",

abstract = "Polymyxin resistance is a major public health threat, as the polymyxins represent “last-line” therapeutics for Gram-negative pathogens resistant to essentially all other antibiotics. Improved understanding of mechanisms of, and risk factors for, polymyxin resistance, as well as infection prevention and stewardship strategies, together with optimization of dosing of polymyxins including in combination regimens, can help to limit the emergence and dissemination of polymyxin resistance.",

keywords = "Colistin, Gram-negative, Polymyxin B, Polymyxins, Resistance",

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T2 - polymyxin resistance

AU - Kaye, Keith S.

AU - Pogue, Jason M.

AU - Tran, Thien B

AU - Nation, Roger L

AU - Li, Jian

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Polymyxin resistance is a major public health threat, as the polymyxins represent “last-line” therapeutics for Gram-negative pathogens resistant to essentially all other antibiotics. Improved understanding of mechanisms of, and risk factors for, polymyxin resistance, as well as infection prevention and stewardship strategies, together with optimization of dosing of polymyxins including in combination regimens, can help to limit the emergence and dissemination of polymyxin resistance.

AB - Polymyxin resistance is a major public health threat, as the polymyxins represent “last-line” therapeutics for Gram-negative pathogens resistant to essentially all other antibiotics. Improved understanding of mechanisms of, and risk factors for, polymyxin resistance, as well as infection prevention and stewardship strategies, together with optimization of dosing of polymyxins including in combination regimens, can help to limit the emergence and dissemination of polymyxin resistance.

KW - Colistin

KW - Gram-negative

KW - Polymyxin B

KW - Polymyxins

KW - Resistance

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U2 - 10.1016/j.idc.2016.02.005

DO - 10.1016/j.idc.2016.02.005

M3 - Review Article

AN - SCOPUS:84991383747

SN - 0891-5520

VL - 30

SP - 391

EP - 414

JO - Infectious Disease Clinics of North America

JF - Infectious Disease Clinics of North America

IS - 2

ER -

Agents of last resort: polymyxin resistance

Abstract

Keywords

UN SDGs

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