Abstract
Polymyxin resistance is a major public health threat, as the polymyxins represent “last-line” therapeutics for Gram-negative pathogens resistant to essentially all other antibiotics. Improved understanding of mechanisms of, and risk factors for, polymyxin resistance, as well as infection prevention and stewardship strategies, together with optimization of dosing of polymyxins including in combination regimens, can help to limit the emergence and dissemination of polymyxin resistance.
| Original language | English |
|---|---|
| Pages (from-to) | 391-414 |
| Number of pages | 24 |
| Journal | Infectious Disease Clinics of North America |
| Volume | 30 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1 Jun 2016 |
Keywords
- Colistin
- Gram-negative
- Polymyxin B
- Polymyxins
- Resistance
Cite this
}
Agents of last resort : polymyxin resistance. / Kaye, Keith S.; Pogue, Jason M.; Tran, Thien B; Nation, Roger L; Li, Jian.
In: Infectious Disease Clinics of North America, Vol. 30, No. 2, 01.06.2016, p. 391-414.Research output: Contribution to journal › Review Article › Research › peer-review
TY - JOUR
T1 - Agents of last resort
T2 - polymyxin resistance
AU - Kaye, Keith S.
AU - Pogue, Jason M.
AU - Tran, Thien B
AU - Nation, Roger L
AU - Li, Jian
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Polymyxin resistance is a major public health threat, as the polymyxins represent “last-line” therapeutics for Gram-negative pathogens resistant to essentially all other antibiotics. Improved understanding of mechanisms of, and risk factors for, polymyxin resistance, as well as infection prevention and stewardship strategies, together with optimization of dosing of polymyxins including in combination regimens, can help to limit the emergence and dissemination of polymyxin resistance.
AB - Polymyxin resistance is a major public health threat, as the polymyxins represent “last-line” therapeutics for Gram-negative pathogens resistant to essentially all other antibiotics. Improved understanding of mechanisms of, and risk factors for, polymyxin resistance, as well as infection prevention and stewardship strategies, together with optimization of dosing of polymyxins including in combination regimens, can help to limit the emergence and dissemination of polymyxin resistance.
KW - Colistin
KW - Gram-negative
KW - Polymyxin B
KW - Polymyxins
KW - Resistance
UR - http://www.scopus.com/inward/record.url?scp=84991383747&partnerID=8YFLogxK
U2 - 10.1016/j.idc.2016.02.005
DO - 10.1016/j.idc.2016.02.005
M3 - Review Article
VL - 30
SP - 391
EP - 414
JO - Infectious Disease Clinics of North America
JF - Infectious Disease Clinics of North America
SN - 0891-5520
IS - 2
ER -