TY - JOUR
T1 - Agents of Last Resort
T2 - An Update on Polymyxin Resistance
AU - Yang, Qiwen
AU - Pogue, Jason M.
AU - Li, Zekun
AU - Nation, Roger L.
AU - Kaye, Keith S.
AU - Li, Jian
PY - 2020/12
Y1 - 2020/12
N2 - Polymyxin resistance is a major public health threat, because the polymyxins represent last-line therapeutics for gram-negative pathogens resistant to essentially all other antibiotics. Minimizing any potential emergence and dissemination of polymyxin resistance relies on an improved understanding of mechanisms of and risk factors for polymyxin resistance, infection prevention and stewardship strategies, together with optimization of dosing of polymyxins (eg, combination regimens).
AB - Polymyxin resistance is a major public health threat, because the polymyxins represent last-line therapeutics for gram-negative pathogens resistant to essentially all other antibiotics. Minimizing any potential emergence and dissemination of polymyxin resistance relies on an improved understanding of mechanisms of and risk factors for polymyxin resistance, infection prevention and stewardship strategies, together with optimization of dosing of polymyxins (eg, combination regimens).
KW - Bacterial stewardship
KW - Gram-negative pathogens
KW - Infection prevention
KW - Polymyxin resistance
KW - Risk factors
UR - http://www.scopus.com/inward/record.url?scp=85091841654&partnerID=8YFLogxK
U2 - 10.1016/j.idc.2020.08.003
DO - 10.1016/j.idc.2020.08.003
M3 - Review Article
AN - SCOPUS:85091841654
VL - 34
SP - 723
EP - 750
JO - Infectious Disease Clinics of North America
JF - Infectious Disease Clinics of North America
SN - 0891-5520
IS - 4
ER -
