Agents of Last Resort: An Update on Polymyxin Resistance

Qiwen Yang, Jason M. Pogue, Zekun Li, Roger L. Nation, Keith S. Kaye, Jian Li

Research output: Contribution to journalReview ArticleResearchpeer-review

13 Citations (Scopus)


Polymyxin resistance is a major public health threat, because the polymyxins represent last-line therapeutics for gram-negative pathogens resistant to essentially all other antibiotics. Minimizing any potential emergence and dissemination of polymyxin resistance relies on an improved understanding of mechanisms of and risk factors for polymyxin resistance, infection prevention and stewardship strategies, together with optimization of dosing of polymyxins (eg, combination regimens).

Original languageEnglish
Pages (from-to)723-750
Number of pages28
JournalInfectious Disease Clinics of North America
Issue number4
Publication statusPublished - Dec 2020


  • Bacterial stewardship
  • Gram-negative pathogens
  • Infection prevention
  • Polymyxin resistance
  • Risk factors

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