Ageing in patients with chronic HIV infection: impact of hypercoagulation

Stephen J. Kent, Charles Flexner

Research output: Contribution to journalReview ArticleOtherpeer-review

Abstract

Ageing is the result of biological events that progressively and irreversibly compromise the function of vital organs and eventually result in death. There is a general perception that ageing is accelerated in people living with HIV, with an increasing body of evidence to support this view. With the introduction of effective antiretroviral therapy, the life expectancy of people living with HIV has improved. Since people with HIV are living longer than previously, while also ageing faster than the general population, there is an increase in HIV-positive patients living with age-related comorbidities. This brief overview of ageing and HIV discusses aspects of the complications of HIV infection as they impact the ageing process. How diseases of age affect patients with HIV provides clues to help unravel the interactions between HIV and ageing that ultimately should help clinicians understand the basis of 'normal' ageing and manage ageing HIV-positive patients more effectively.

Original languageEnglish
Number of pages4
JournalAIDS Research and Therapy
Volume15
Issue number1
DOIs
Publication statusPublished - 24 Nov 2018

Keywords

  • Ageing
  • Antiretroviral therapy
  • Coagulation
  • Fraility
  • HIV
  • Inflammation

Cite this

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Ageing in patients with chronic HIV infection: impact of hypercoagulation. / Kent, Stephen J.; Flexner, Charles.

In: AIDS Research and Therapy, Vol. 15, No. 1, 24.11.2018.

Research output: Contribution to journalReview ArticleOtherpeer-review

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AU - Flexner, Charles

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AB - Ageing is the result of biological events that progressively and irreversibly compromise the function of vital organs and eventually result in death. There is a general perception that ageing is accelerated in people living with HIV, with an increasing body of evidence to support this view. With the introduction of effective antiretroviral therapy, the life expectancy of people living with HIV has improved. Since people with HIV are living longer than previously, while also ageing faster than the general population, there is an increase in HIV-positive patients living with age-related comorbidities. This brief overview of ageing and HIV discusses aspects of the complications of HIV infection as they impact the ageing process. How diseases of age affect patients with HIV provides clues to help unravel the interactions between HIV and ageing that ultimately should help clinicians understand the basis of 'normal' ageing and manage ageing HIV-positive patients more effectively.

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