Age-specific breast cancer risk by body mass index and familial risk: Prospective family study cohort (ProF-SC) 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis 11 Medical and Health Sciences 1117 Public Health and Health Services

John L. Hopper, Gillian S. Dite, Robert J. MacInnis, Yuyan Liao, Nur Zeinomar, Julia A. Knight, Melissa C. Southey, Roger L. Milne, Wendy K. Chung, Graham G. Giles, Jeanine M. Genkinger, Sue Anne McLachlan, Michael L. Friedlander, Antonis C. Antoniou, Prue C. Weideman, Gord Glendon, Stephanie Nesci, Irene L. Andrulis, Saundra S. Buys, Mary B. Daly & 3 others Esther M. John, Kelly Anne Phillips, Mary Beth Terry

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background: The association between body mass index (BMI) and risk of breast cancer depends on time of life, but it is unknown whether this association depends on a woman's familial risk. Methods: We conducted a prospective study of a cohort enriched for familial risk consisting of 16,035 women from 6701 families in the Breast Cancer Family Registry and the Kathleen Cunningham Foundation Consortium for Research into Familial Breast Cancer followed for up to 20 years (mean 10.5 years). There were 896 incident breast cancers (mean age at diagnosis 55.7 years). We used Cox regression to model BMI risk associations as a function of menopausal status, age, and underlying familial risk based on pedigree data using the Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA), all measured at baseline. Results: The strength and direction of the BMI risk association depended on baseline menopausal status (P < 0.001); after adjusting for menopausal status, the association did not depend on age at baseline (P = 0.6). In terms of absolute risk, the negative association with BMI for premenopausal women has a much smaller influence than the positive association with BMI for postmenopausal women. Women at higher familial risk have a much larger difference in absolute risk depending on their BMI than women at lower familial risk. Conclusions: The greater a woman's familial risk, the greater the influence of BMI on her absolute postmenopausal breast cancer risk. Given that age-adjusted BMI is correlated across adulthood, maintaining a healthy weight throughout adult life is particularly important for women with a family history of breast cancer.

Original languageEnglish
Article number132
Number of pages11
JournalBreast Cancer Research
Volume20
Issue number1
DOIs
Publication statusPublished - 3 Nov 2018

Keywords

  • Body mass index
  • Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm
  • Breast cancer
  • Familial risk
  • Gene-environment interaction

Cite this

Hopper, John L. ; Dite, Gillian S. ; MacInnis, Robert J. ; Liao, Yuyan ; Zeinomar, Nur ; Knight, Julia A. ; Southey, Melissa C. ; Milne, Roger L. ; Chung, Wendy K. ; Giles, Graham G. ; Genkinger, Jeanine M. ; McLachlan, Sue Anne ; Friedlander, Michael L. ; Antoniou, Antonis C. ; Weideman, Prue C. ; Glendon, Gord ; Nesci, Stephanie ; Andrulis, Irene L. ; Buys, Saundra S. ; Daly, Mary B. ; John, Esther M. ; Phillips, Kelly Anne ; Terry, Mary Beth. / Age-specific breast cancer risk by body mass index and familial risk : Prospective family study cohort (ProF-SC) 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis 11 Medical and Health Sciences 1117 Public Health and Health Services. In: Breast Cancer Research. 2018 ; Vol. 20, No. 1.
@article{7487dd5bb28544dd89f472b87225657e,
title = "Age-specific breast cancer risk by body mass index and familial risk: Prospective family study cohort (ProF-SC) 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis 11 Medical and Health Sciences 1117 Public Health and Health Services",
abstract = "Background: The association between body mass index (BMI) and risk of breast cancer depends on time of life, but it is unknown whether this association depends on a woman's familial risk. Methods: We conducted a prospective study of a cohort enriched for familial risk consisting of 16,035 women from 6701 families in the Breast Cancer Family Registry and the Kathleen Cunningham Foundation Consortium for Research into Familial Breast Cancer followed for up to 20 years (mean 10.5 years). There were 896 incident breast cancers (mean age at diagnosis 55.7 years). We used Cox regression to model BMI risk associations as a function of menopausal status, age, and underlying familial risk based on pedigree data using the Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA), all measured at baseline. Results: The strength and direction of the BMI risk association depended on baseline menopausal status (P < 0.001); after adjusting for menopausal status, the association did not depend on age at baseline (P = 0.6). In terms of absolute risk, the negative association with BMI for premenopausal women has a much smaller influence than the positive association with BMI for postmenopausal women. Women at higher familial risk have a much larger difference in absolute risk depending on their BMI than women at lower familial risk. Conclusions: The greater a woman's familial risk, the greater the influence of BMI on her absolute postmenopausal breast cancer risk. Given that age-adjusted BMI is correlated across adulthood, maintaining a healthy weight throughout adult life is particularly important for women with a family history of breast cancer.",
keywords = "Body mass index, Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm, Breast cancer, Familial risk, Gene-environment interaction",
author = "Hopper, {John L.} and Dite, {Gillian S.} and MacInnis, {Robert J.} and Yuyan Liao and Nur Zeinomar and Knight, {Julia A.} and Southey, {Melissa C.} and Milne, {Roger L.} and Chung, {Wendy K.} and Giles, {Graham G.} and Genkinger, {Jeanine M.} and McLachlan, {Sue Anne} and Friedlander, {Michael L.} and Antoniou, {Antonis C.} and Weideman, {Prue C.} and Gord Glendon and Stephanie Nesci and Andrulis, {Irene L.} and Buys, {Saundra S.} and Daly, {Mary B.} and John, {Esther M.} and Phillips, {Kelly Anne} and Terry, {Mary Beth}",
year = "2018",
month = "11",
day = "3",
doi = "10.1186/s13058-018-1056-1",
language = "English",
volume = "20",
journal = "Breast Cancer Research",
issn = "1465-5411",
publisher = "Springer-Verlag London Ltd.",
number = "1",

}

Hopper, JL, Dite, GS, MacInnis, RJ, Liao, Y, Zeinomar, N, Knight, JA, Southey, MC, Milne, RL, Chung, WK, Giles, GG, Genkinger, JM, McLachlan, SA, Friedlander, ML, Antoniou, AC, Weideman, PC, Glendon, G, Nesci, S, Andrulis, IL, Buys, SS, Daly, MB, John, EM, Phillips, KA & Terry, MB 2018, 'Age-specific breast cancer risk by body mass index and familial risk: Prospective family study cohort (ProF-SC) 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis 11 Medical and Health Sciences 1117 Public Health and Health Services' Breast Cancer Research, vol. 20, no. 1, 132. https://doi.org/10.1186/s13058-018-1056-1

Age-specific breast cancer risk by body mass index and familial risk : Prospective family study cohort (ProF-SC) 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis 11 Medical and Health Sciences 1117 Public Health and Health Services. / Hopper, John L.; Dite, Gillian S.; MacInnis, Robert J.; Liao, Yuyan; Zeinomar, Nur; Knight, Julia A.; Southey, Melissa C.; Milne, Roger L.; Chung, Wendy K.; Giles, Graham G.; Genkinger, Jeanine M.; McLachlan, Sue Anne; Friedlander, Michael L.; Antoniou, Antonis C.; Weideman, Prue C.; Glendon, Gord; Nesci, Stephanie; Andrulis, Irene L.; Buys, Saundra S.; Daly, Mary B.; John, Esther M.; Phillips, Kelly Anne; Terry, Mary Beth.

In: Breast Cancer Research, Vol. 20, No. 1, 132, 03.11.2018.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Age-specific breast cancer risk by body mass index and familial risk

T2 - Prospective family study cohort (ProF-SC) 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis 11 Medical and Health Sciences 1117 Public Health and Health Services

AU - Hopper, John L.

AU - Dite, Gillian S.

AU - MacInnis, Robert J.

AU - Liao, Yuyan

AU - Zeinomar, Nur

AU - Knight, Julia A.

AU - Southey, Melissa C.

AU - Milne, Roger L.

AU - Chung, Wendy K.

AU - Giles, Graham G.

AU - Genkinger, Jeanine M.

AU - McLachlan, Sue Anne

AU - Friedlander, Michael L.

AU - Antoniou, Antonis C.

AU - Weideman, Prue C.

AU - Glendon, Gord

AU - Nesci, Stephanie

AU - Andrulis, Irene L.

AU - Buys, Saundra S.

AU - Daly, Mary B.

AU - John, Esther M.

AU - Phillips, Kelly Anne

AU - Terry, Mary Beth

PY - 2018/11/3

Y1 - 2018/11/3

N2 - Background: The association between body mass index (BMI) and risk of breast cancer depends on time of life, but it is unknown whether this association depends on a woman's familial risk. Methods: We conducted a prospective study of a cohort enriched for familial risk consisting of 16,035 women from 6701 families in the Breast Cancer Family Registry and the Kathleen Cunningham Foundation Consortium for Research into Familial Breast Cancer followed for up to 20 years (mean 10.5 years). There were 896 incident breast cancers (mean age at diagnosis 55.7 years). We used Cox regression to model BMI risk associations as a function of menopausal status, age, and underlying familial risk based on pedigree data using the Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA), all measured at baseline. Results: The strength and direction of the BMI risk association depended on baseline menopausal status (P < 0.001); after adjusting for menopausal status, the association did not depend on age at baseline (P = 0.6). In terms of absolute risk, the negative association with BMI for premenopausal women has a much smaller influence than the positive association with BMI for postmenopausal women. Women at higher familial risk have a much larger difference in absolute risk depending on their BMI than women at lower familial risk. Conclusions: The greater a woman's familial risk, the greater the influence of BMI on her absolute postmenopausal breast cancer risk. Given that age-adjusted BMI is correlated across adulthood, maintaining a healthy weight throughout adult life is particularly important for women with a family history of breast cancer.

AB - Background: The association between body mass index (BMI) and risk of breast cancer depends on time of life, but it is unknown whether this association depends on a woman's familial risk. Methods: We conducted a prospective study of a cohort enriched for familial risk consisting of 16,035 women from 6701 families in the Breast Cancer Family Registry and the Kathleen Cunningham Foundation Consortium for Research into Familial Breast Cancer followed for up to 20 years (mean 10.5 years). There were 896 incident breast cancers (mean age at diagnosis 55.7 years). We used Cox regression to model BMI risk associations as a function of menopausal status, age, and underlying familial risk based on pedigree data using the Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA), all measured at baseline. Results: The strength and direction of the BMI risk association depended on baseline menopausal status (P < 0.001); after adjusting for menopausal status, the association did not depend on age at baseline (P = 0.6). In terms of absolute risk, the negative association with BMI for premenopausal women has a much smaller influence than the positive association with BMI for postmenopausal women. Women at higher familial risk have a much larger difference in absolute risk depending on their BMI than women at lower familial risk. Conclusions: The greater a woman's familial risk, the greater the influence of BMI on her absolute postmenopausal breast cancer risk. Given that age-adjusted BMI is correlated across adulthood, maintaining a healthy weight throughout adult life is particularly important for women with a family history of breast cancer.

KW - Body mass index

KW - Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm

KW - Breast cancer

KW - Familial risk

KW - Gene-environment interaction

UR - http://www.scopus.com/inward/record.url?scp=85056084996&partnerID=8YFLogxK

U2 - 10.1186/s13058-018-1056-1

DO - 10.1186/s13058-018-1056-1

M3 - Article

VL - 20

JO - Breast Cancer Research

JF - Breast Cancer Research

SN - 1465-5411

IS - 1

M1 - 132

ER -