Age-related differences in glycaemic control, cardiovascular disease risk factors and treatment in patients with type 2 diabetes

A cross-sectional study from the Australian National Diabetes Audit

Natalie Nanayakkara, Sanjeeva Ranasinha, Adelle M. Gadowski, Wendy A. Davis, Jeffrey Ronald Flack, Natalie Wischer, Sof Andrikopoulos, Sophia Zoungas

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Objective To compare the glycaemic control and cardiovascular risk factor profiles of younger and older patients with type 2 diabetes. Cross-sectional analysis of data from the 2015 Australian National Diabetes Audit was undertaken. Methods Data were obtained from adults with type 2 diabetes presenting to Australian secondary/tertiary diabetes centres. Logistic regression examined associations with glycated haemoglobin A1c (HbA1c) >7% (53 mmol/mol) and cardiovascular risk factors. Results Data from 3492 patients were analysed. Mean (±SD) age was 62.9±12.5 years, mean diabetes duration 13.5±9.4 years and mean HbA1c 8.2%±1.8%. Mean HbA1c was 8.6%±2.1% and 8.0%±1.6% for the younger (<60 years) and older subgroups (≥60 years), respectively (p<0.001). The adjusted OR (aOR) of HbA1c above >7.0% was 1.5 times higher (95% CI 1.22 to 1.84) for younger patients compared with older patients after adjustment for gender, smoking, diabetes duration, renal function and body mass index. Younger patients were also more likely to have dyslipidaemia (aOR 2.02, 95% CI 1.53 to 2.68; p<0.001), be obese (aOR 1.25, 95% CI 1.05 to 1.49; p<0.001) and be current smokers (aOR 2.13 95% CI 1.64 to 2.77; p<0.001) than older patients. Conclusions Younger age was associated with poorer glycaemic control and adverse cardiovascular risk factor profiles. It is imperative to optimise and monitor treatment in order to improve long-term outcomes.

Original languageEnglish
Article numbere020677
Number of pages9
JournalBMJ Open
Volume8
Issue number8
DOIs
Publication statusPublished - 1 Aug 2018

Keywords

  • epidemiology
  • general diabetes
  • general medicine (see internal medicine)

Cite this

@article{e6147fcc61174205b0a26755cdc88c94,
title = "Age-related differences in glycaemic control, cardiovascular disease risk factors and treatment in patients with type 2 diabetes: A cross-sectional study from the Australian National Diabetes Audit",
abstract = "Objective To compare the glycaemic control and cardiovascular risk factor profiles of younger and older patients with type 2 diabetes. Cross-sectional analysis of data from the 2015 Australian National Diabetes Audit was undertaken. Methods Data were obtained from adults with type 2 diabetes presenting to Australian secondary/tertiary diabetes centres. Logistic regression examined associations with glycated haemoglobin A1c (HbA1c) >7{\%} (53 mmol/mol) and cardiovascular risk factors. Results Data from 3492 patients were analysed. Mean (±SD) age was 62.9±12.5 years, mean diabetes duration 13.5±9.4 years and mean HbA1c 8.2{\%}±1.8{\%}. Mean HbA1c was 8.6{\%}±2.1{\%} and 8.0{\%}±1.6{\%} for the younger (<60 years) and older subgroups (≥60 years), respectively (p<0.001). The adjusted OR (aOR) of HbA1c above >7.0{\%} was 1.5 times higher (95{\%} CI 1.22 to 1.84) for younger patients compared with older patients after adjustment for gender, smoking, diabetes duration, renal function and body mass index. Younger patients were also more likely to have dyslipidaemia (aOR 2.02, 95{\%} CI 1.53 to 2.68; p<0.001), be obese (aOR 1.25, 95{\%} CI 1.05 to 1.49; p<0.001) and be current smokers (aOR 2.13 95{\%} CI 1.64 to 2.77; p<0.001) than older patients. Conclusions Younger age was associated with poorer glycaemic control and adverse cardiovascular risk factor profiles. It is imperative to optimise and monitor treatment in order to improve long-term outcomes.",
keywords = "epidemiology, general diabetes, general medicine (see internal medicine)",
author = "Natalie Nanayakkara and Sanjeeva Ranasinha and Gadowski, {Adelle M.} and Davis, {Wendy A.} and Flack, {Jeffrey Ronald} and Natalie Wischer and Sof Andrikopoulos and Sophia Zoungas",
year = "2018",
month = "8",
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doi = "10.1136/bmjopen-2017-020677",
language = "English",
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Age-related differences in glycaemic control, cardiovascular disease risk factors and treatment in patients with type 2 diabetes : A cross-sectional study from the Australian National Diabetes Audit. / Nanayakkara, Natalie; Ranasinha, Sanjeeva; Gadowski, Adelle M.; Davis, Wendy A.; Flack, Jeffrey Ronald; Wischer, Natalie; Andrikopoulos, Sof; Zoungas, Sophia.

In: BMJ Open, Vol. 8, No. 8, e020677, 01.08.2018.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Age-related differences in glycaemic control, cardiovascular disease risk factors and treatment in patients with type 2 diabetes

T2 - A cross-sectional study from the Australian National Diabetes Audit

AU - Nanayakkara, Natalie

AU - Ranasinha, Sanjeeva

AU - Gadowski, Adelle M.

AU - Davis, Wendy A.

AU - Flack, Jeffrey Ronald

AU - Wischer, Natalie

AU - Andrikopoulos, Sof

AU - Zoungas, Sophia

PY - 2018/8/1

Y1 - 2018/8/1

N2 - Objective To compare the glycaemic control and cardiovascular risk factor profiles of younger and older patients with type 2 diabetes. Cross-sectional analysis of data from the 2015 Australian National Diabetes Audit was undertaken. Methods Data were obtained from adults with type 2 diabetes presenting to Australian secondary/tertiary diabetes centres. Logistic regression examined associations with glycated haemoglobin A1c (HbA1c) >7% (53 mmol/mol) and cardiovascular risk factors. Results Data from 3492 patients were analysed. Mean (±SD) age was 62.9±12.5 years, mean diabetes duration 13.5±9.4 years and mean HbA1c 8.2%±1.8%. Mean HbA1c was 8.6%±2.1% and 8.0%±1.6% for the younger (<60 years) and older subgroups (≥60 years), respectively (p<0.001). The adjusted OR (aOR) of HbA1c above >7.0% was 1.5 times higher (95% CI 1.22 to 1.84) for younger patients compared with older patients after adjustment for gender, smoking, diabetes duration, renal function and body mass index. Younger patients were also more likely to have dyslipidaemia (aOR 2.02, 95% CI 1.53 to 2.68; p<0.001), be obese (aOR 1.25, 95% CI 1.05 to 1.49; p<0.001) and be current smokers (aOR 2.13 95% CI 1.64 to 2.77; p<0.001) than older patients. Conclusions Younger age was associated with poorer glycaemic control and adverse cardiovascular risk factor profiles. It is imperative to optimise and monitor treatment in order to improve long-term outcomes.

AB - Objective To compare the glycaemic control and cardiovascular risk factor profiles of younger and older patients with type 2 diabetes. Cross-sectional analysis of data from the 2015 Australian National Diabetes Audit was undertaken. Methods Data were obtained from adults with type 2 diabetes presenting to Australian secondary/tertiary diabetes centres. Logistic regression examined associations with glycated haemoglobin A1c (HbA1c) >7% (53 mmol/mol) and cardiovascular risk factors. Results Data from 3492 patients were analysed. Mean (±SD) age was 62.9±12.5 years, mean diabetes duration 13.5±9.4 years and mean HbA1c 8.2%±1.8%. Mean HbA1c was 8.6%±2.1% and 8.0%±1.6% for the younger (<60 years) and older subgroups (≥60 years), respectively (p<0.001). The adjusted OR (aOR) of HbA1c above >7.0% was 1.5 times higher (95% CI 1.22 to 1.84) for younger patients compared with older patients after adjustment for gender, smoking, diabetes duration, renal function and body mass index. Younger patients were also more likely to have dyslipidaemia (aOR 2.02, 95% CI 1.53 to 2.68; p<0.001), be obese (aOR 1.25, 95% CI 1.05 to 1.49; p<0.001) and be current smokers (aOR 2.13 95% CI 1.64 to 2.77; p<0.001) than older patients. Conclusions Younger age was associated with poorer glycaemic control and adverse cardiovascular risk factor profiles. It is imperative to optimise and monitor treatment in order to improve long-term outcomes.

KW - epidemiology

KW - general diabetes

KW - general medicine (see internal medicine)

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DO - 10.1136/bmjopen-2017-020677

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