Age-related clonal hematopoiesis and HIV infection are associated with geriatric outcomes: The ARCHIVE study

Win Min Han; Hossain M.S. Sazzad; Mark Bloch; David A. Baker; Norman Roth; Ellen Bowden-Reid; Don Smith; Jennifer F. Hoy; Ian Woolley; Robert Finlayson; David J. Templeton; Gail Matthews; Jane Costello; Mark A. Dawson; Sarah Jane Dawson; Mark N. Polizzotto; Kathy Petoumenos; Paul Yeh; Nila J. Dharan; The ARCHIVE Study Group

doi:10.1016/j.xcrm.2024.101835

Age-related clonal hematopoiesis and HIV infection are associated with geriatric outcomes: The ARCHIVE study

Win Min Han, Hossain M.S. Sazzad, Mark Bloch, David A. Baker, Norman Roth, Ellen Bowden-Reid, Don Smith, Jennifer F. Hoy, Ian Woolley, Robert Finlayson, David J. Templeton, Gail Matthews, Jane Costello, Mark A. Dawson, Sarah Jane Dawson, Mark N. Polizzotto, Kathy Petoumenos, Paul Yeh, Nila J. Dharan, The ARCHIVE Study Group

Research output: Contribution to journal › Article › Research › peer-review

2 Citations (Scopus)

Abstract

While HIV infection and clonal hematopoiesis (CH) have been linked with inflammatory dysregulation and an increased risk of aging-related comorbidities, their relationship with clinical geriatric syndromes has not been well defined. In the Age-related Clonal Haematopoiesis in an HIV Evaluation Cohort (ARCHIVE) study (NCT04641013), we measure associations between HIV and CH and geriatric syndromes. Of 345 participants (176 with HIV and 169 without HIV), 23% had at least one mutation associated with CH: 27% with HIV and 18% without HIV (p = 0.048). In adjusted analyses, HIV infection is independently associated with increased phenotypic age acceleration (coefficient 1.73, 95% confidence interval [CI] 0.3, 3.16) and CH is independently associated with being frail (vs. pre-frail/robust; odds ratio 2.38, 95% CI 1.01, 5.67) and with having reduced quality of life (coefficient −2.18, 95% CI −3.92, −0.44). Our findings suggest that HIV is associated with increased biological age and that CH may be used as a biomarker for adverse geriatric outcomes.

Original language	English
Article number	101835
Number of pages	15
Journal	Cell Reports Medicine
Volume	5
Issue number	12
DOIs	https://doi.org/10.1016/j.xcrm.2024.101835
Publication status	Published - 17 Dec 2024

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

aging-related comorbidities
clonal hematopoiesis
frailty
geriatric syndromes
HIV
multimorbidity
phenotypic age acceleration
quality of life

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Han, W. M., Sazzad, H. M. S., Bloch, M., Baker, D. A., Roth, N., Bowden-Reid, E., Smith, D., Hoy, J. F., Woolley, I., Finlayson, R., Templeton, D. J., Matthews, G., Costello, J., Dawson, M. A., Dawson, S. J., Polizzotto, M. N., Petoumenos, K., Yeh, P., Dharan, N. J., & The ARCHIVE Study Group (2024). Age-related clonal hematopoiesis and HIV infection are associated with geriatric outcomes: The ARCHIVE study. Cell Reports Medicine, 5(12), Article 101835. https://doi.org/10.1016/j.xcrm.2024.101835

@article{ff13d0630f4a4fe1acbf7992d13b31b2,

title = "Age-related clonal hematopoiesis and HIV infection are associated with geriatric outcomes: The ARCHIVE study",

abstract = "While HIV infection and clonal hematopoiesis (CH) have been linked with inflammatory dysregulation and an increased risk of aging-related comorbidities, their relationship with clinical geriatric syndromes has not been well defined. In the Age-related Clonal Haematopoiesis in an HIV Evaluation Cohort (ARCHIVE) study (NCT04641013), we measure associations between HIV and CH and geriatric syndromes. Of 345 participants (176 with HIV and 169 without HIV), 23\% had at least one mutation associated with CH: 27\% with HIV and 18\% without HIV (p = 0.048). In adjusted analyses, HIV infection is independently associated with increased phenotypic age acceleration (coefficient 1.73, 95\% confidence interval [CI] 0.3, 3.16) and CH is independently associated with being frail (vs. pre-frail/robust; odds ratio 2.38, 95\% CI 1.01, 5.67) and with having reduced quality of life (coefficient −2.18, 95\% CI −3.92, −0.44). Our findings suggest that HIV is associated with increased biological age and that CH may be used as a biomarker for adverse geriatric outcomes.",

keywords = "aging-related comorbidities, clonal hematopoiesis, frailty, geriatric syndromes, HIV, multimorbidity, phenotypic age acceleration, quality of life",

author = "Han, \{Win Min\} and Sazzad, \{Hossain M.S.\} and Mark Bloch and Baker, \{David A.\} and Norman Roth and Ellen Bowden-Reid and Don Smith and Hoy, \{Jennifer F.\} and Ian Woolley and Robert Finlayson and Templeton, \{David J.\} and Gail Matthews and Jane Costello and Dawson, \{Mark A.\} and Dawson, \{Sarah Jane\} and Polizzotto, \{Mark N.\} and Kathy Petoumenos and Paul Yeh and Dharan, \{Nila J.\} and Diana Winter and Helen Lau and Kathryn Acklom and Sally Price and Jessica O'Bryan and Brett Sinclair and \{The ARCHIVE Study Group\}",

note = "Publisher Copyright: {\textcopyright} 2024 The Authors",

year = "2024",

month = dec,

day = "17",

doi = "10.1016/j.xcrm.2024.101835",

language = "English",

volume = "5",

journal = "Cell Reports Medicine",

issn = "2666-3791",

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Han, WM, Sazzad, HMS, Bloch, M, Baker, DA, Roth, N, Bowden-Reid, E, Smith, D, Hoy, JF , Woolley, I, Finlayson, R, Templeton, DJ, Matthews, G, Costello, J, Dawson, MA, Dawson, SJ, Polizzotto, MN, Petoumenos, K, Yeh, P, Dharan, NJ & The ARCHIVE Study Group 2024, 'Age-related clonal hematopoiesis and HIV infection are associated with geriatric outcomes: The ARCHIVE study', Cell Reports Medicine, vol. 5, no. 12, 101835. https://doi.org/10.1016/j.xcrm.2024.101835

TY - JOUR

T1 - Age-related clonal hematopoiesis and HIV infection are associated with geriatric outcomes

T2 - The ARCHIVE study

AU - Han, Win Min

AU - Sazzad, Hossain M.S.

AU - Bloch, Mark

AU - Baker, David A.

AU - Roth, Norman

AU - Bowden-Reid, Ellen

AU - Smith, Don

AU - Hoy, Jennifer F.

AU - Woolley, Ian

AU - Finlayson, Robert

AU - Templeton, David J.

AU - Matthews, Gail

AU - Costello, Jane

AU - Dawson, Mark A.

AU - Dawson, Sarah Jane

AU - Polizzotto, Mark N.

AU - Petoumenos, Kathy

AU - Yeh, Paul

AU - Dharan, Nila J.

AU - Winter, Diana

AU - Lau, Helen

AU - Acklom, Kathryn

AU - Price, Sally

AU - O'Bryan, Jessica

AU - Sinclair, Brett

AU - The ARCHIVE Study Group

PY - 2024/12/17

Y1 - 2024/12/17

N2 - While HIV infection and clonal hematopoiesis (CH) have been linked with inflammatory dysregulation and an increased risk of aging-related comorbidities, their relationship with clinical geriatric syndromes has not been well defined. In the Age-related Clonal Haematopoiesis in an HIV Evaluation Cohort (ARCHIVE) study (NCT04641013), we measure associations between HIV and CH and geriatric syndromes. Of 345 participants (176 with HIV and 169 without HIV), 23% had at least one mutation associated with CH: 27% with HIV and 18% without HIV (p = 0.048). In adjusted analyses, HIV infection is independently associated with increased phenotypic age acceleration (coefficient 1.73, 95% confidence interval [CI] 0.3, 3.16) and CH is independently associated with being frail (vs. pre-frail/robust; odds ratio 2.38, 95% CI 1.01, 5.67) and with having reduced quality of life (coefficient −2.18, 95% CI −3.92, −0.44). Our findings suggest that HIV is associated with increased biological age and that CH may be used as a biomarker for adverse geriatric outcomes.

AB - While HIV infection and clonal hematopoiesis (CH) have been linked with inflammatory dysregulation and an increased risk of aging-related comorbidities, their relationship with clinical geriatric syndromes has not been well defined. In the Age-related Clonal Haematopoiesis in an HIV Evaluation Cohort (ARCHIVE) study (NCT04641013), we measure associations between HIV and CH and geriatric syndromes. Of 345 participants (176 with HIV and 169 without HIV), 23% had at least one mutation associated with CH: 27% with HIV and 18% without HIV (p = 0.048). In adjusted analyses, HIV infection is independently associated with increased phenotypic age acceleration (coefficient 1.73, 95% confidence interval [CI] 0.3, 3.16) and CH is independently associated with being frail (vs. pre-frail/robust; odds ratio 2.38, 95% CI 1.01, 5.67) and with having reduced quality of life (coefficient −2.18, 95% CI −3.92, −0.44). Our findings suggest that HIV is associated with increased biological age and that CH may be used as a biomarker for adverse geriatric outcomes.

KW - aging-related comorbidities

KW - clonal hematopoiesis

KW - frailty

KW - geriatric syndromes

KW - HIV

KW - multimorbidity

KW - phenotypic age acceleration

KW - quality of life

UR - https://www.scopus.com/pages/publications/85212205032

U2 - 10.1016/j.xcrm.2024.101835

DO - 10.1016/j.xcrm.2024.101835

M3 - Article

C2 - 39626674

AN - SCOPUS:85212205032

SN - 2666-3791

VL - 5

JO - Cell Reports Medicine

JF - Cell Reports Medicine

IS - 12

M1 - 101835

ER -

Age-related clonal hematopoiesis and HIV infection are associated with geriatric outcomes: The ARCHIVE study

Abstract

UN SDGs

Keywords

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