Age-related changes in tissue macrophages precede cardiac functional impairment

Ruvantha Ignatius Alexander Pinto; James Walter Godwin; Anjana Chandran; Lucy Kate Hersey; Alexei Ilinykh; Ryan Debuque; Lina Wang; Nadia Alicia Rosenthal

Age-related changes in tissue macrophages precede cardiac functional impairment

Ruvantha Ignatius Alexander Pinto, James Walter Godwin, Anjana Chandran, Lucy Kate Hersey, Alexei Ilinykh, Ryan Debuque, Lina Wang, Nadia Alicia Rosenthal

Australian Regenerative Medicine Institute

Research output: Contribution to journal › Article › Research › peer-review

57 Citations (Scopus)

Abstract

Cardiac tissue macrophages (cTMs) are abundant in the murine heart but the extent to which the cTM phenotype changes with age is unknown. This study characterizes aging-dependent phenotypic changes in cTM subsets. Using theCx3cr1(GFP/+) mouse reporter line where GFP marks cTMs, and the tissue macrophage marker Mrc1, we show that two major cardiac tissue macrophage subsets, Mrc1-GFP(hi) and Mrc1+GFP(hi) cTMs, are present in the young (

Original language	English
Pages (from-to)	399 - 413
Number of pages	15
Journal	Aging Clinical and Experimental Research
Volume	6
Issue number	5
Publication status	Published - 2014

Cite this

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title = "Age-related changes in tissue macrophages precede cardiac functional impairment",

abstract = "Cardiac tissue macrophages (cTMs) are abundant in the murine heart but the extent to which the cTM phenotype changes with age is unknown. This study characterizes aging-dependent phenotypic changes in cTM subsets. Using theCx3cr1(GFP/+) mouse reporter line where GFP marks cTMs, and the tissue macrophage marker Mrc1, we show that two major cardiac tissue macrophage subsets, Mrc1-GFP(hi) and Mrc1+GFP(hi) cTMs, are present in the young (",

author = "Pinto, {Ruvantha Ignatius Alexander} and Godwin, {James Walter} and Anjana Chandran and Hersey, {Lucy Kate} and Alexei Ilinykh and Ryan Debuque and Lina Wang and Rosenthal, {Nadia Alicia}",

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journal = "Aging Clinical and Experimental Research",

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T1 - Age-related changes in tissue macrophages precede cardiac functional impairment

AU - Pinto, Ruvantha Ignatius Alexander

AU - Godwin, James Walter

AU - Chandran, Anjana

AU - Hersey, Lucy Kate

AU - Ilinykh, Alexei

AU - Debuque, Ryan

AU - Wang, Lina

AU - Rosenthal, Nadia Alicia

PY - 2014

Y1 - 2014

N2 - Cardiac tissue macrophages (cTMs) are abundant in the murine heart but the extent to which the cTM phenotype changes with age is unknown. This study characterizes aging-dependent phenotypic changes in cTM subsets. Using theCx3cr1(GFP/+) mouse reporter line where GFP marks cTMs, and the tissue macrophage marker Mrc1, we show that two major cardiac tissue macrophage subsets, Mrc1-GFP(hi) and Mrc1+GFP(hi) cTMs, are present in the young (

AB - Cardiac tissue macrophages (cTMs) are abundant in the murine heart but the extent to which the cTM phenotype changes with age is unknown. This study characterizes aging-dependent phenotypic changes in cTM subsets. Using theCx3cr1(GFP/+) mouse reporter line where GFP marks cTMs, and the tissue macrophage marker Mrc1, we show that two major cardiac tissue macrophage subsets, Mrc1-GFP(hi) and Mrc1+GFP(hi) cTMs, are present in the young (

M3 - Article

VL - 6

SP - 399

EP - 413

JO - Aging Clinical and Experimental Research

JF - Aging Clinical and Experimental Research

SN - 1594-0667

IS - 5

ER -