Age-related changes in tissue macrophages precede cardiac functional impairment

Ruvantha Ignatius Alexander Pinto, James Walter Godwin, Anjana Chandran, Lucy Kate Hersey, Alexei Ilinykh, Ryan Debuque, Lina Wang, Nadia Alicia Rosenthal

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Abstract

Cardiac tissue macrophages (cTMs) are abundant in the murine heart but the extent to which the cTM phenotype changes with age is unknown. This study characterizes aging-dependent phenotypic changes in cTM subsets. Using theCx3cr1(GFP/+) mouse reporter line where GFP marks cTMs, and the tissue macrophage marker Mrc1, we show that two major cardiac tissue macrophage subsets, Mrc1-GFP(hi) and Mrc1+GFP(hi) cTMs, are present in the young (
Original languageEnglish
Pages (from-to)399 - 413
Number of pages15
JournalAging Clinical and Experimental Research
Volume6
Issue number5
Publication statusPublished - 2014

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