Age-related changes in the innervation of the prostate gland: implications for prostate cancer initiation and progression

Carl William White, Jin Han Xie, Sabatino Ventura

Research output: Contribution to journalReview ArticleResearchpeer-review

36 Citations (Scopus)


The adult prostate gland grows and develops under hormonal control while its physiological functions are controlled by the autonomic nervous system. The prostate gland receives sympathetic input via the hypogastric nerve and parasympathetic input via the pelvic nerve. In addition, the hypogastric and pelvic nerves also provide sensory inputs to the gland. This review provides a summary of the innervation of the adult prostate gland and describes the changes which occur with age and disease. Growth and development of the prostate gland is age dependent as is the occurrence of both benign prostate disease and prostate cancer. In parallel, the activity and influence of both the sympathetic and parasympathetic nervous system changes with age. The influence of the sympathetic nervous system on benign prostatic hyperplasia is well documented and this review considers the possibility of a link between changes in autonomic innervation and prostate cancer progression.

Original languageEnglish
Pages (from-to)206-215
Number of pages10
Issue number3
Publication statusPublished - Jul 2013

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