Age related changes in extracellular materials in the inner wall of Schlemm's canal

P. G. McMenamin, W. R. Lee

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Abstract

An electron microscopic investigation was conducted to study the extracellular materials of the endothelial meshwork in the human outflow apparatus. A quantitative analysis was made to determine the changes which occur with age. Tissue from 20 cases, ages 4 months to 80 years, was examined. A morphometric technique which utilised a grid of 100 random points was used to estimate the percentage area of extracellular components in the endothelial meshwork. It was found that while the percentage area occupied by amorphous ground substance and fibrillar material decreased with age, the percentage area occupied by the electron-dense component increased. Variation in distribution of these components was noted both between cases of similar age and also within one section. A qualitative description of other changes in the trabecular meshwork is given, and the limitations of the technique are discussed.

Original languageEnglish
Pages (from-to)159-172
Number of pages14
JournalAlbrecht von Graefes Archiv für Klinische und Experimentelle Ophthalmologie
Volume212
Issue number3-4
DOIs
Publication statusPublished - 1 Feb 1980
Externally publishedYes

Cite this

@article{9e4f9be52b604bdabd68e0efdf554e58,
title = "Age related changes in extracellular materials in the inner wall of Schlemm's canal",
abstract = "An electron microscopic investigation was conducted to study the extracellular materials of the endothelial meshwork in the human outflow apparatus. A quantitative analysis was made to determine the changes which occur with age. Tissue from 20 cases, ages 4 months to 80 years, was examined. A morphometric technique which utilised a grid of 100 random points was used to estimate the percentage area of extracellular components in the endothelial meshwork. It was found that while the percentage area occupied by amorphous ground substance and fibrillar material decreased with age, the percentage area occupied by the electron-dense component increased. Variation in distribution of these components was noted both between cases of similar age and also within one section. A qualitative description of other changes in the trabecular meshwork is given, and the limitations of the technique are discussed.",
author = "McMenamin, {P. G.} and Lee, {W. R.}",
year = "1980",
month = "2",
day = "1",
doi = "10.1007/BF00410512",
language = "English",
volume = "212",
pages = "159--172",
journal = "Graefes Archive for Clinical and Experimental Ophthalmology",
issn = "0721-832X",
publisher = "Springer-Verlag London Ltd.",
number = "3-4",

}

Age related changes in extracellular materials in the inner wall of Schlemm's canal. / McMenamin, P. G.; Lee, W. R.

In: Albrecht von Graefes Archiv für Klinische und Experimentelle Ophthalmologie, Vol. 212, No. 3-4, 01.02.1980, p. 159-172.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Age related changes in extracellular materials in the inner wall of Schlemm's canal

AU - McMenamin, P. G.

AU - Lee, W. R.

PY - 1980/2/1

Y1 - 1980/2/1

N2 - An electron microscopic investigation was conducted to study the extracellular materials of the endothelial meshwork in the human outflow apparatus. A quantitative analysis was made to determine the changes which occur with age. Tissue from 20 cases, ages 4 months to 80 years, was examined. A morphometric technique which utilised a grid of 100 random points was used to estimate the percentage area of extracellular components in the endothelial meshwork. It was found that while the percentage area occupied by amorphous ground substance and fibrillar material decreased with age, the percentage area occupied by the electron-dense component increased. Variation in distribution of these components was noted both between cases of similar age and also within one section. A qualitative description of other changes in the trabecular meshwork is given, and the limitations of the technique are discussed.

AB - An electron microscopic investigation was conducted to study the extracellular materials of the endothelial meshwork in the human outflow apparatus. A quantitative analysis was made to determine the changes which occur with age. Tissue from 20 cases, ages 4 months to 80 years, was examined. A morphometric technique which utilised a grid of 100 random points was used to estimate the percentage area of extracellular components in the endothelial meshwork. It was found that while the percentage area occupied by amorphous ground substance and fibrillar material decreased with age, the percentage area occupied by the electron-dense component increased. Variation in distribution of these components was noted both between cases of similar age and also within one section. A qualitative description of other changes in the trabecular meshwork is given, and the limitations of the technique are discussed.

UR - http://www.scopus.com/inward/record.url?scp=0018881157&partnerID=8YFLogxK

U2 - 10.1007/BF00410512

DO - 10.1007/BF00410512

M3 - Article

VL - 212

SP - 159

EP - 172

JO - Graefes Archive for Clinical and Experimental Ophthalmology

JF - Graefes Archive for Clinical and Experimental Ophthalmology

SN - 0721-832X

IS - 3-4

ER -