Abstract
An electron microscopic investigation was conducted to study the extracellular materials of the endothelial meshwork in the human outflow apparatus. A quantitative analysis was made to determine the changes which occur with age. Tissue from 20 cases, ages 4 months to 80 years, was examined. A morphometric technique which utilised a grid of 100 random points was used to estimate the percentage area of extracellular components in the endothelial meshwork. It was found that while the percentage area occupied by amorphous ground substance and fibrillar material decreased with age, the percentage area occupied by the electron-dense component increased. Variation in distribution of these components was noted both between cases of similar age and also within one section. A qualitative description of other changes in the trabecular meshwork is given, and the limitations of the technique are discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 159-172 |
| Number of pages | 14 |
| Journal | Albrecht von Graefes Archiv für Klinische und Experimentelle Ophthalmologie |
| Volume | 212 |
| Issue number | 3-4 |
| DOIs | |
| Publication status | Published - 1 Feb 1980 |
| Externally published | Yes |
Cite this
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Age related changes in extracellular materials in the inner wall of Schlemm's canal. / McMenamin, P. G.; Lee, W. R.
In: Albrecht von Graefes Archiv für Klinische und Experimentelle Ophthalmologie, Vol. 212, No. 3-4, 01.02.1980, p. 159-172.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Age related changes in extracellular materials in the inner wall of Schlemm's canal
AU - McMenamin, P. G.
AU - Lee, W. R.
PY - 1980/2/1
Y1 - 1980/2/1
N2 - An electron microscopic investigation was conducted to study the extracellular materials of the endothelial meshwork in the human outflow apparatus. A quantitative analysis was made to determine the changes which occur with age. Tissue from 20 cases, ages 4 months to 80 years, was examined. A morphometric technique which utilised a grid of 100 random points was used to estimate the percentage area of extracellular components in the endothelial meshwork. It was found that while the percentage area occupied by amorphous ground substance and fibrillar material decreased with age, the percentage area occupied by the electron-dense component increased. Variation in distribution of these components was noted both between cases of similar age and also within one section. A qualitative description of other changes in the trabecular meshwork is given, and the limitations of the technique are discussed.
AB - An electron microscopic investigation was conducted to study the extracellular materials of the endothelial meshwork in the human outflow apparatus. A quantitative analysis was made to determine the changes which occur with age. Tissue from 20 cases, ages 4 months to 80 years, was examined. A morphometric technique which utilised a grid of 100 random points was used to estimate the percentage area of extracellular components in the endothelial meshwork. It was found that while the percentage area occupied by amorphous ground substance and fibrillar material decreased with age, the percentage area occupied by the electron-dense component increased. Variation in distribution of these components was noted both between cases of similar age and also within one section. A qualitative description of other changes in the trabecular meshwork is given, and the limitations of the technique are discussed.
UR - http://www.scopus.com/inward/record.url?scp=0018881157&partnerID=8YFLogxK
U2 - 10.1007/BF00410512
DO - 10.1007/BF00410512
M3 - Article
VL - 212
SP - 159
EP - 172
JO - Graefes Archive for Clinical and Experimental Ophthalmology
JF - Graefes Archive for Clinical and Experimental Ophthalmology
SN - 0721-832X
IS - 3-4
ER -