Age and CGG-repeat length are associated with neuromotor impairments in at-risk females with the FMR1 premutation

Claudine Kraan, Darren Hocking, Nellie Georgiou-Karistianis, Sylvia Ann Metcalfe, Alison D Archibald, Joanne Fielding, Julian Norman Trollor, John Lockyer Bradshaw, Jonathon Cohen, Kim Marie Cornish

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Recent studies report a higher risk of dementia and motor symptoms in females with the fragile X mental retardation 1 premutation (PM-carriers) than has hitherto been appreciated. Here, we use dual-task gait paradigms to identify potential markers of cognitive and motor decline in female PM-carriers. Spatiotemporal gait characteristics and variability of gait were assessed during single- and dual-task conditions in 28 female PM-carriers (mean age 41.32 ? 8.03 years) and 31 female controls with normal fragile Xmental retardation 1 alleles (mean age 41.61 ? 8.30 years). Despite comparable gait characteristics at baseline, gait performance was significantly poorer for PM-carriers when performing concurrent working memory tasks (counting backwards by 3 s or 7 s) when compared with controls. Correlational analyses showed that low working memory capacity was significantly associated with dual-task interference for the gait domains of pace (speed, step length) and variability (step time, swing time) in PM-carriers. Multiple regression analyses further showed that the interaction between age and CGG repeat length was strongly predictive of gait variability during dual-task performance. These findings indicate for the first time that vulnerability in specific domains of gait control may act as sensitive surrogate markers of future decline in female PM-carriers.
Original languageEnglish
Pages (from-to)2179.e7 - 2179.e13
Number of pages7
JournalNeurobiology of Aging
Volume35
Issue number9
DOIs
Publication statusPublished - 2014

Cite this

Kraan, Claudine ; Hocking, Darren ; Georgiou-Karistianis, Nellie ; Metcalfe, Sylvia Ann ; Archibald, Alison D ; Fielding, Joanne ; Trollor, Julian Norman ; Bradshaw, John Lockyer ; Cohen, Jonathon ; Cornish, Kim Marie. / Age and CGG-repeat length are associated with neuromotor impairments in at-risk females with the FMR1 premutation. In: Neurobiology of Aging. 2014 ; Vol. 35, No. 9. pp. 2179.e7 - 2179.e13.
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title = "Age and CGG-repeat length are associated with neuromotor impairments in at-risk females with the FMR1 premutation",
abstract = "Recent studies report a higher risk of dementia and motor symptoms in females with the fragile X mental retardation 1 premutation (PM-carriers) than has hitherto been appreciated. Here, we use dual-task gait paradigms to identify potential markers of cognitive and motor decline in female PM-carriers. Spatiotemporal gait characteristics and variability of gait were assessed during single- and dual-task conditions in 28 female PM-carriers (mean age 41.32 ? 8.03 years) and 31 female controls with normal fragile Xmental retardation 1 alleles (mean age 41.61 ? 8.30 years). Despite comparable gait characteristics at baseline, gait performance was significantly poorer for PM-carriers when performing concurrent working memory tasks (counting backwards by 3 s or 7 s) when compared with controls. Correlational analyses showed that low working memory capacity was significantly associated with dual-task interference for the gait domains of pace (speed, step length) and variability (step time, swing time) in PM-carriers. Multiple regression analyses further showed that the interaction between age and CGG repeat length was strongly predictive of gait variability during dual-task performance. These findings indicate for the first time that vulnerability in specific domains of gait control may act as sensitive surrogate markers of future decline in female PM-carriers.",
author = "Claudine Kraan and Darren Hocking and Nellie Georgiou-Karistianis and Metcalfe, {Sylvia Ann} and Archibald, {Alison D} and Joanne Fielding and Trollor, {Julian Norman} and Bradshaw, {John Lockyer} and Jonathon Cohen and Cornish, {Kim Marie}",
year = "2014",
doi = "10.1016/j.neurobiolaging.2014.03.018",
language = "English",
volume = "35",
pages = "2179.e7 -- 2179.e13",
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Age and CGG-repeat length are associated with neuromotor impairments in at-risk females with the FMR1 premutation. / Kraan, Claudine; Hocking, Darren; Georgiou-Karistianis, Nellie; Metcalfe, Sylvia Ann; Archibald, Alison D; Fielding, Joanne; Trollor, Julian Norman; Bradshaw, John Lockyer; Cohen, Jonathon; Cornish, Kim Marie.

In: Neurobiology of Aging, Vol. 35, No. 9, 2014, p. 2179.e7 - 2179.e13.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Age and CGG-repeat length are associated with neuromotor impairments in at-risk females with the FMR1 premutation

AU - Kraan, Claudine

AU - Hocking, Darren

AU - Georgiou-Karistianis, Nellie

AU - Metcalfe, Sylvia Ann

AU - Archibald, Alison D

AU - Fielding, Joanne

AU - Trollor, Julian Norman

AU - Bradshaw, John Lockyer

AU - Cohen, Jonathon

AU - Cornish, Kim Marie

PY - 2014

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N2 - Recent studies report a higher risk of dementia and motor symptoms in females with the fragile X mental retardation 1 premutation (PM-carriers) than has hitherto been appreciated. Here, we use dual-task gait paradigms to identify potential markers of cognitive and motor decline in female PM-carriers. Spatiotemporal gait characteristics and variability of gait were assessed during single- and dual-task conditions in 28 female PM-carriers (mean age 41.32 ? 8.03 years) and 31 female controls with normal fragile Xmental retardation 1 alleles (mean age 41.61 ? 8.30 years). Despite comparable gait characteristics at baseline, gait performance was significantly poorer for PM-carriers when performing concurrent working memory tasks (counting backwards by 3 s or 7 s) when compared with controls. Correlational analyses showed that low working memory capacity was significantly associated with dual-task interference for the gait domains of pace (speed, step length) and variability (step time, swing time) in PM-carriers. Multiple regression analyses further showed that the interaction between age and CGG repeat length was strongly predictive of gait variability during dual-task performance. These findings indicate for the first time that vulnerability in specific domains of gait control may act as sensitive surrogate markers of future decline in female PM-carriers.

AB - Recent studies report a higher risk of dementia and motor symptoms in females with the fragile X mental retardation 1 premutation (PM-carriers) than has hitherto been appreciated. Here, we use dual-task gait paradigms to identify potential markers of cognitive and motor decline in female PM-carriers. Spatiotemporal gait characteristics and variability of gait were assessed during single- and dual-task conditions in 28 female PM-carriers (mean age 41.32 ? 8.03 years) and 31 female controls with normal fragile Xmental retardation 1 alleles (mean age 41.61 ? 8.30 years). Despite comparable gait characteristics at baseline, gait performance was significantly poorer for PM-carriers when performing concurrent working memory tasks (counting backwards by 3 s or 7 s) when compared with controls. Correlational analyses showed that low working memory capacity was significantly associated with dual-task interference for the gait domains of pace (speed, step length) and variability (step time, swing time) in PM-carriers. Multiple regression analyses further showed that the interaction between age and CGG repeat length was strongly predictive of gait variability during dual-task performance. These findings indicate for the first time that vulnerability in specific domains of gait control may act as sensitive surrogate markers of future decline in female PM-carriers.

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