Age and CGG-repeat length are associated with neuromotor impairments in at-risk females with the FMR1 premutation

Claudine Kraan, Darren Hocking, Nellie Georgiou-Karistianis, Sylvia Ann Metcalfe, Alison D Archibald, Joanne Fielding, Julian Norman Trollor, John Lockyer Bradshaw, Jonathon Cohen, Kim Marie Cornish

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13 Citations (Scopus)


Recent studies report a higher risk of dementia and motor symptoms in females with the fragile X mental retardation 1 premutation (PM-carriers) than has hitherto been appreciated. Here, we use dual-task gait paradigms to identify potential markers of cognitive and motor decline in female PM-carriers. Spatiotemporal gait characteristics and variability of gait were assessed during single- and dual-task conditions in 28 female PM-carriers (mean age 41.32 ? 8.03 years) and 31 female controls with normal fragile Xmental retardation 1 alleles (mean age 41.61 ? 8.30 years). Despite comparable gait characteristics at baseline, gait performance was significantly poorer for PM-carriers when performing concurrent working memory tasks (counting backwards by 3 s or 7 s) when compared with controls. Correlational analyses showed that low working memory capacity was significantly associated with dual-task interference for the gait domains of pace (speed, step length) and variability (step time, swing time) in PM-carriers. Multiple regression analyses further showed that the interaction between age and CGG repeat length was strongly predictive of gait variability during dual-task performance. These findings indicate for the first time that vulnerability in specific domains of gait control may act as sensitive surrogate markers of future decline in female PM-carriers.
Original languageEnglish
Pages (from-to)2179.e7 - 2179.e13
Number of pages7
JournalNeurobiology of Aging
Issue number9
Publication statusPublished - 2014

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