Adverse obstetric and perinatal outcomes in subfertile women conceiving without assisted reproductive technologies

Alice Jaques, David J Amor, H W Gordon Baker, David Lindsay Healy, Obioha C Ukoumunne, Sue Breheny, Claire Garrett, Jane L Halliday

Research output: Contribution to journalArticleResearchpeer-review

103 Citations (Scopus)


OBJECTIVE: To determine whether adverse perinatal outcomes are increased in subfertile women. DESIGN: Cohort study. SETTING: Two tertiary assisted reproductive technologies (ART) centers; Victorian births register. PATIENT(S): Records of women who registered with the clinics (1991-2000), but did not have an infant using ART, were linked to the birth register (1991-2004) to identify singleton non-ART births within 5 years of registration (N = 2171). Controls, matched by maternal age and year of infant s birth, were selected randomly from birth records (N = 4363). INTERVENTIONS: None. MAIN OUTCOME MEASURE(S): Adverse obstetric and perinatal outcomes. RESULT(S): After adjusting for confounders, compared with controls, subfertile women had increased odds of hypertension or preeclampsia (adjusted odds ratio [OR] 1.29, 1.02-1.61), antepartum hemorrhage (adjusted OR 1.41, 1.05-1.89), perinatal death (adjusted OR 2.19, 1.10-4.36), low birth weight (adjusted OR 1.44, 1.11-1.85), preterm birth
Original languageEnglish
Pages (from-to)2674 - 2679
Number of pages6
JournalFertility and Sterility
Issue number7
Publication statusPublished - 2010

Cite this