Adverse haemodynamic effects of sodium bicarbonate in metabolic acidosis

D. J. Cooper, L. I.G. Worthley

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In a patient with viral pneumonia, acute respiratory and renal failure and metabolic acidosis, a reduction in left ventricular stroke work was observed on the three occasions that 100 ml of 8.4% sodium bicarbonate was infused. Blood pressure and cardiac output decreased on two of the occassions. Since intravenous sodium bicarbonate may produce adverse cardiovascular effects, a right heart catheter should be inserted to monitor these effects when alkali therapy is administered to an acutely ill patient with metabolic acidosis.

Original languageEnglish
Pages (from-to)425-427
Number of pages3
JournalIntensive Care Medicine
Issue number6
Publication statusPublished - 1 Nov 1987
Externally publishedYes


  • Acute renal failure
  • Metabolic acidosis
  • Sodium bicarbonate

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