Advantages of breast cancer visualization and characterization using synchrotron radiation phase-contrast tomography

Serena Pacile, Patrycja Baran, Christian Dullin, Matthew Dimmock, Darren Lockie, Jeannine Missbach-Gunter, Harry Quiney, Mikkaela McCormack, Sheridan Mayo, Darren Thompson, Yakov Nesterets, Chris Hall, Konstantin Pavlov, Zdenka Prodanovic, Maura Tonutti, Agostino Accardo, Jane Fox, Seyedamir Tavakoli Taba, Sarah Lewis, Patrick Brennan & 3 others Daniel Hausermann, Guiliana Tromba, Tim Gureyev

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Abstract

The aim of this study was to highlight the advantages that propagation-based phase-contrast computed tomography (PB-CT) with synchrotron radiation can provide in breast cancer diagnostics. For the first time, a fresh and intact mastectomy sample from a 60 year old patient was scanned on the IMBL beamline at the Australian Synchrotron in PB-CT mode and reconstructed. The clinical picture was described and characterized by an experienced breast radiologist, who underlined the advantages of providing diagnosis on a PB-CT volume rather than conventional two-dimensional modalities. Subsequently, the image quality was assessed by 11 breast radiologists and medical imaging experts using a radiological scoring system. The results indicate that, with the radiation dose delivered to the sample being equal, the accuracy of a diagnosis made on PB-CT images is significantly higher than one using conventional techniques.

Original languageEnglish
Pages (from-to)1460-1466
Number of pages7
JournalJournal of Synchrotron Radiation
Volume25
Issue number5
DOIs
Publication statusPublished - 1 Sep 2018

Keywords

  • breast cancer imaging
  • phase-contrast breast CT
  • synchrotron radiation

Cite this

Pacile, Serena ; Baran, Patrycja ; Dullin, Christian ; Dimmock, Matthew ; Lockie, Darren ; Missbach-Gunter, Jeannine ; Quiney, Harry ; McCormack, Mikkaela ; Mayo, Sheridan ; Thompson, Darren ; Nesterets, Yakov ; Hall, Chris ; Pavlov, Konstantin ; Prodanovic, Zdenka ; Tonutti, Maura ; Accardo, Agostino ; Fox, Jane ; Taba, Seyedamir Tavakoli ; Lewis, Sarah ; Brennan, Patrick ; Hausermann, Daniel ; Tromba, Guiliana ; Gureyev, Tim. / Advantages of breast cancer visualization and characterization using synchrotron radiation phase-contrast tomography. In: Journal of Synchrotron Radiation. 2018 ; Vol. 25, No. 5. pp. 1460-1466.
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abstract = "The aim of this study was to highlight the advantages that propagation-based phase-contrast computed tomography (PB-CT) with synchrotron radiation can provide in breast cancer diagnostics. For the first time, a fresh and intact mastectomy sample from a 60 year old patient was scanned on the IMBL beamline at the Australian Synchrotron in PB-CT mode and reconstructed. The clinical picture was described and characterized by an experienced breast radiologist, who underlined the advantages of providing diagnosis on a PB-CT volume rather than conventional two-dimensional modalities. Subsequently, the image quality was assessed by 11 breast radiologists and medical imaging experts using a radiological scoring system. The results indicate that, with the radiation dose delivered to the sample being equal, the accuracy of a diagnosis made on PB-CT images is significantly higher than one using conventional techniques.",
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author = "Serena Pacile and Patrycja Baran and Christian Dullin and Matthew Dimmock and Darren Lockie and Jeannine Missbach-Gunter and Harry Quiney and Mikkaela McCormack and Sheridan Mayo and Darren Thompson and Yakov Nesterets and Chris Hall and Konstantin Pavlov and Zdenka Prodanovic and Maura Tonutti and Agostino Accardo and Jane Fox and Taba, {Seyedamir Tavakoli} and Sarah Lewis and Patrick Brennan and Daniel Hausermann and Guiliana Tromba and Tim Gureyev",
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Pacile, S, Baran, P, Dullin, C, Dimmock, M, Lockie, D, Missbach-Gunter, J, Quiney, H, McCormack, M, Mayo, S, Thompson, D, Nesterets, Y, Hall, C, Pavlov, K, Prodanovic, Z, Tonutti, M, Accardo, A, Fox, J, Taba, ST, Lewis, S, Brennan, P, Hausermann, D, Tromba, G & Gureyev, T 2018, 'Advantages of breast cancer visualization and characterization using synchrotron radiation phase-contrast tomography', Journal of Synchrotron Radiation, vol. 25, no. 5, pp. 1460-1466. https://doi.org/10.1107/S1600577518010172, https://doi.org/10.1107/S1600577518010172

Advantages of breast cancer visualization and characterization using synchrotron radiation phase-contrast tomography. / Pacile, Serena; Baran, Patrycja; Dullin, Christian; Dimmock, Matthew; Lockie, Darren; Missbach-Gunter, Jeannine; Quiney, Harry; McCormack, Mikkaela; Mayo, Sheridan; Thompson, Darren; Nesterets, Yakov; Hall, Chris; Pavlov, Konstantin; Prodanovic, Zdenka; Tonutti, Maura; Accardo, Agostino; Fox, Jane; Taba, Seyedamir Tavakoli; Lewis, Sarah; Brennan, Patrick; Hausermann, Daniel; Tromba, Guiliana; Gureyev, Tim.

In: Journal of Synchrotron Radiation, Vol. 25, No. 5, 01.09.2018, p. 1460-1466.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Pacile, Serena

AU - Baran, Patrycja

AU - Dullin, Christian

AU - Dimmock, Matthew

AU - Lockie, Darren

AU - Missbach-Gunter, Jeannine

AU - Quiney, Harry

AU - McCormack, Mikkaela

AU - Mayo, Sheridan

AU - Thompson, Darren

AU - Nesterets, Yakov

AU - Hall, Chris

AU - Pavlov, Konstantin

AU - Prodanovic, Zdenka

AU - Tonutti, Maura

AU - Accardo, Agostino

AU - Fox, Jane

AU - Taba, Seyedamir Tavakoli

AU - Lewis, Sarah

AU - Brennan, Patrick

AU - Hausermann, Daniel

AU - Tromba, Guiliana

AU - Gureyev, Tim

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AB - The aim of this study was to highlight the advantages that propagation-based phase-contrast computed tomography (PB-CT) with synchrotron radiation can provide in breast cancer diagnostics. For the first time, a fresh and intact mastectomy sample from a 60 year old patient was scanned on the IMBL beamline at the Australian Synchrotron in PB-CT mode and reconstructed. The clinical picture was described and characterized by an experienced breast radiologist, who underlined the advantages of providing diagnosis on a PB-CT volume rather than conventional two-dimensional modalities. Subsequently, the image quality was assessed by 11 breast radiologists and medical imaging experts using a radiological scoring system. The results indicate that, with the radiation dose delivered to the sample being equal, the accuracy of a diagnosis made on PB-CT images is significantly higher than one using conventional techniques.

KW - breast cancer imaging

KW - phase-contrast breast CT

KW - synchrotron radiation

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JO - Journal of Synchrotron Radiation

JF - Journal of Synchrotron Radiation

SN - 0909-0495

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