Advantages of breast cancer visualization and characterization using synchrotron radiation phase-contrast tomography

Serena Pacile, Patrycja Baran, Christian Dullin, Matthew Dimmock, Darren Lockie, Jeannine Missbach-Gunter, Harry Quiney, Mikkaela McCormack, Sheridan Mayo, Darren Thompson, Yakov Nesterets, Chris Hall, Konstantin Pavlov, Zdenka Prodanovic, Maura Tonutti, Agostino Accardo, Jane Fox, Seyedamir Tavakoli Taba, Sarah Lewis, Patrick BrennanDaniel Hausermann, Guiliana Tromba, Tim Gureyev

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11 Citations (Scopus)


The aim of this study was to highlight the advantages that propagation-based phase-contrast computed tomography (PB-CT) with synchrotron radiation can provide in breast cancer diagnostics. For the first time, a fresh and intact mastectomy sample from a 60 year old patient was scanned on the IMBL beamline at the Australian Synchrotron in PB-CT mode and reconstructed. The clinical picture was described and characterized by an experienced breast radiologist, who underlined the advantages of providing diagnosis on a PB-CT volume rather than conventional two-dimensional modalities. Subsequently, the image quality was assessed by 11 breast radiologists and medical imaging experts using a radiological scoring system. The results indicate that, with the radiation dose delivered to the sample being equal, the accuracy of a diagnosis made on PB-CT images is significantly higher than one using conventional techniques.

Original languageEnglish
Pages (from-to)1460-1466
Number of pages7
JournalJournal of Synchrotron Radiation
Issue number5
Publication statusPublished - 1 Sep 2018


  • breast cancer imaging
  • phase-contrast breast CT
  • synchrotron radiation

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