In recent years, understanding of the interaction between the neuroendocrine and immune-inflammatory systems has greatly increased. In essence,communication between these two systems constitutes a negative feedback control loop which regulates the inflammatory response. Recent evidence has implicated dysfunction of this interaction as a contributing factor to the initiation and/or perpetuation of inflammatory diseases such as rheumatoid arthritis (RA). Interest in these findings has led to subsequent investigation of neuroendocrine function in non-inflammatory rheumatic disease such as fibromyalgia syndrome.This paper will review the evidence supporting a role for neuroendocrine function in the regulation of immune-inflammatory systems, and evidence for the dysfunction of this interaction in rheumatic disease.
|Number of pages||9|
|Journal||Australian and New Zealand Journal of Medicine|
|Publication status||Published - 1996|
Morand, E. F., Cooley, H., Leech, M. T., & Little John, G. O. (1996). Advances in the understanding of neuroendocrine function in rheumatic disease. Australian and New Zealand Journal of Medicine, 26(4), 543-551.