Advances in the understanding of neuroendocrine function in rheumatic disease

E. F. Morand, H. Cooley, Michelle Theresa Leech, G. O. Little John

Research output: Contribution to journalArticleOtherpeer-review

7 Citations (Scopus)


In recent years, understanding of the interaction between the neuroendocrine and immune-inflammatory systems has greatly increased. In essence,communication between these two systems constitutes a negative feedback control loop which regulates the inflammatory response. Recent evidence has implicated dysfunction of this interaction as a contributing factor to the initiation and/or perpetuation of inflammatory diseases such as rheumatoid arthritis (RA). Interest in these findings has led to subsequent investigation of neuroendocrine function in non-inflammatory rheumatic disease such as fibromyalgia syndrome.This paper will review the evidence supporting a role for neuroendocrine function in the regulation of immune-inflammatory systems, and evidence for the dysfunction of this interaction in rheumatic disease.
Original languageEnglish
Pages (from-to)543-551
Number of pages9
JournalAustralian and New Zealand Journal of Medicine
Issue number4
Publication statusPublished - 1996

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