Advances in the synthesis of 1,2,4-triazolo[1,5-a][1,3,5]triazines (5-azapurines) and their biological activity

Koon Kee Kow; Anton V. Dolzhenko

doi:10.3987/REV-18-901

Advances in the synthesis of 1,2,4-triazolo[1,5-a][1,3,5]triazines (5-azapurines) and their biological activity

Koon Kee Kow
, Anton V. Dolzhenko

Malaysia Sch of Pharmacy

Research output: Contribution to journal › Review Article › Other › peer-review

10 Citations (Scopus)

Abstract

The 1,2,4-triazolo[1,5-a][1,3,5]triazine system has been recognized as a promising scaffold for drug development purposes. The isosteric relationship between this skeleton and purines plays an important role in the research towards the development of bioactive 1,2,4-triazolo[1,5-a][1,3,5]triazine derivatives. This review discusses recently developed strategies for the synthesis of 1,2,4-triazolo[1,5-a][1,3,5]triazines and advances achieved in studies on biological activity of compounds constructed using this skeleton.

Original language	English
Pages (from-to)	175-203
Number of pages	29
Journal	Heterocycles
Volume	98
Issue number	2
DOIs	https://doi.org/10.3987/REV-18-901
Publication status	Published - 1 Feb 2019

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10.3987/REV-18-901

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title = "Advances in the synthesis of 1,2,4-triazolo[1,5-a][1,3,5]triazines (5-azapurines) and their biological activity",

abstract = "The 1,2,4-triazolo[1,5-a][1,3,5]triazine system has been recognized as a promising scaffold for drug development purposes. The isosteric relationship between this skeleton and purines plays an important role in the research towards the development of bioactive 1,2,4-triazolo[1,5-a][1,3,5]triazine derivatives. This review discusses recently developed strategies for the synthesis of 1,2,4-triazolo[1,5-a][1,3,5]triazines and advances achieved in studies on biological activity of compounds constructed using this skeleton.",

author = "Kow, \{Koon Kee\} and Dolzhenko, \{Anton V.\}",

note = "Funding Information: Grant Scheme, grant number FRGS/1/2015/SG01/MUSM/03/1. Funding Information: This work is supported by the Ministry of Higher Education, Malaysia under Fundamental Research Grant Scheme, grant number FRGS/1/2015/SG01/MUSM/03/1. Funding Information: This work is supported by the Ministry of Higher Education, Publisher Copyright: {\textcopyright} 2019 The Japan Institute of Heterocyclic Chemistry Received Copyright: Copyright 2019 Elsevier B.V., All rights reserved.",

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doi = "10.3987/REV-18-901",

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AU - Dolzhenko, Anton V.

N1 - Funding Information: Grant Scheme, grant number FRGS/1/2015/SG01/MUSM/03/1. Funding Information: This work is supported by the Ministry of Higher Education, Malaysia under Fundamental Research Grant Scheme, grant number FRGS/1/2015/SG01/MUSM/03/1. Funding Information: This work is supported by the Ministry of Higher Education, Publisher Copyright: © 2019 The Japan Institute of Heterocyclic Chemistry Received Copyright: Copyright 2019 Elsevier B.V., All rights reserved.

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N2 - The 1,2,4-triazolo[1,5-a][1,3,5]triazine system has been recognized as a promising scaffold for drug development purposes. The isosteric relationship between this skeleton and purines plays an important role in the research towards the development of bioactive 1,2,4-triazolo[1,5-a][1,3,5]triazine derivatives. This review discusses recently developed strategies for the synthesis of 1,2,4-triazolo[1,5-a][1,3,5]triazines and advances achieved in studies on biological activity of compounds constructed using this skeleton.

AB - The 1,2,4-triazolo[1,5-a][1,3,5]triazine system has been recognized as a promising scaffold for drug development purposes. The isosteric relationship between this skeleton and purines plays an important role in the research towards the development of bioactive 1,2,4-triazolo[1,5-a][1,3,5]triazine derivatives. This review discusses recently developed strategies for the synthesis of 1,2,4-triazolo[1,5-a][1,3,5]triazines and advances achieved in studies on biological activity of compounds constructed using this skeleton.

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DO - 10.3987/REV-18-901

M3 - Review Article

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VL - 98

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JO - Heterocycles

JF - Heterocycles

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ER -

Advances in the synthesis of 1,2,4-triazolo[1,5-a][1,3,5]triazines (5-azapurines) and their biological activity

Abstract

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Synthesis of 5-azapurine derivatives as new modulators of purinergic receptors

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Advances in the synthesis of 1,2,4-triazolo[1,5-a][1,3,5]triazines (5-azapurines) and their biological activity

Abstract

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Synthesis of 5-azapurine derivatives as new modulators of purinergic receptors

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