TY - JOUR
T1 - Advances in the synthesis of 1,2,4-triazolo[1,5-a][1,3,5]triazines (5-azapurines) and their biological activity
AU - Kow, Koon Kee
AU - Dolzhenko, Anton V.
N1 - Funding Information:
Grant Scheme, grant number FRGS/1/2015/SG01/MUSM/03/1.
Funding Information:
This work is supported by the Ministry of Higher Education, Malaysia under Fundamental Research Grant Scheme, grant number FRGS/1/2015/SG01/MUSM/03/1.
Funding Information:
This work is supported by the Ministry of Higher Education,
Publisher Copyright:
© 2019 The Japan Institute of Heterocyclic Chemistry Received
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019/2/1
Y1 - 2019/2/1
N2 - The 1,2,4-triazolo[1,5-a][1,3,5]triazine system has been recognized as a promising scaffold for drug development purposes. The isosteric relationship between this skeleton and purines plays an important role in the research towards the development of bioactive 1,2,4-triazolo[1,5-a][1,3,5]triazine derivatives. This review discusses recently developed strategies for the synthesis of 1,2,4-triazolo[1,5-a][1,3,5]triazines and advances achieved in studies on biological activity of compounds constructed using this skeleton.
AB - The 1,2,4-triazolo[1,5-a][1,3,5]triazine system has been recognized as a promising scaffold for drug development purposes. The isosteric relationship between this skeleton and purines plays an important role in the research towards the development of bioactive 1,2,4-triazolo[1,5-a][1,3,5]triazine derivatives. This review discusses recently developed strategies for the synthesis of 1,2,4-triazolo[1,5-a][1,3,5]triazines and advances achieved in studies on biological activity of compounds constructed using this skeleton.
UR - http://www.scopus.com/inward/record.url?scp=85064863059&partnerID=8YFLogxK
U2 - 10.3987/REV-18-901
DO - 10.3987/REV-18-901
M3 - Review Article
AN - SCOPUS:85064863059
SN - 0385-5414
VL - 98
SP - 175
EP - 203
JO - Heterocycles
JF - Heterocycles
IS - 2
ER -