Advances in the pathogenesis of Goodpasture's disease: From epitopes to autoantibodies to effector T cells

Joshua Ooi; Stephen Roger Holdsworth; Arthur Richard Kitching

Advances in the pathogenesis of Goodpasture's disease: From epitopes to autoantibodies to effector T cells

Joshua Ooi
, Stephen Roger Holdsworth
, Arthur Richard Kitching

Research output: Contribution to journal › Article › Research › peer-review

Abstract

Goodpasture s disease, an organ-specific autoimmune disease is manifest by rapidly progressive glomerulonephritis and pulmonary hemorrhage. Studies into the pathogenesis of this disease have shed light on the autoantigen (the non-collagenous domain of the alpha3 chain of type IV collagen, alpha3(IV)NC1) and its epitopes, as well as the involvement of autoantibodies and cellular effectors in disease.

Original language	English
Pages (from-to)	295 - 300
Number of pages	6
Journal	Journal of Autoimmunity
Volume	31
Issue number	3
Publication status	Published - 2008

Cite this

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title = "Advances in the pathogenesis of Goodpasture's disease: From epitopes to autoantibodies to effector T cells",

abstract = "Goodpasture s disease, an organ-specific autoimmune disease is manifest by rapidly progressive glomerulonephritis and pulmonary hemorrhage. Studies into the pathogenesis of this disease have shed light on the autoantigen (the non-collagenous domain of the alpha3 chain of type IV collagen, alpha3(IV)NC1) and its epitopes, as well as the involvement of autoantibodies and cellular effectors in disease.",

author = "Joshua Ooi and Holdsworth, \{Stephen Roger\} and Kitching, \{Arthur Richard\}",

year = "2008",

language = "English",

volume = "31",

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journal = "Journal of Autoimmunity",

issn = "0896-8411",

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T1 - Advances in the pathogenesis of Goodpasture's disease: From epitopes to autoantibodies to effector T cells

AU - Ooi, Joshua

AU - Holdsworth, Stephen Roger

AU - Kitching, Arthur Richard

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N2 - Goodpasture s disease, an organ-specific autoimmune disease is manifest by rapidly progressive glomerulonephritis and pulmonary hemorrhage. Studies into the pathogenesis of this disease have shed light on the autoantigen (the non-collagenous domain of the alpha3 chain of type IV collagen, alpha3(IV)NC1) and its epitopes, as well as the involvement of autoantibodies and cellular effectors in disease.

AB - Goodpasture s disease, an organ-specific autoimmune disease is manifest by rapidly progressive glomerulonephritis and pulmonary hemorrhage. Studies into the pathogenesis of this disease have shed light on the autoantigen (the non-collagenous domain of the alpha3 chain of type IV collagen, alpha3(IV)NC1) and its epitopes, as well as the involvement of autoantibodies and cellular effectors in disease.

UR - http://www.ncbi.nlm.nih.gov/pubmed/18502098

M3 - Article

SN - 0896-8411

VL - 31

SP - 295

EP - 300

JO - Journal of Autoimmunity

JF - Journal of Autoimmunity

IS - 3

ER -

Advances in the pathogenesis of Goodpasture's disease: From epitopes to autoantibodies to effector T cells

Abstract

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