Advances in the pathogenesis of Goodpasture's disease: From epitopes to autoantibodies to effector T cells

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Abstract

Goodpasture s disease, an organ-specific autoimmune disease is manifest by rapidly progressive glomerulonephritis and pulmonary hemorrhage. Studies into the pathogenesis of this disease have shed light on the autoantigen (the non-collagenous domain of the alpha3 chain of type IV collagen, alpha3(IV)NC1) and its epitopes, as well as the involvement of autoantibodies and cellular effectors in disease.
Original languageEnglish
Pages (from-to)295 - 300
Number of pages6
JournalJournal of Autoimmunity
Volume31
Issue number3
Publication statusPublished - 2008

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