Advances in the pathogenesis of Goodpasture's disease: From epitopes to autoantibodies to effector T cells

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Abstract

Goodpasture s disease, an organ-specific autoimmune disease is manifest by rapidly progressive glomerulonephritis and pulmonary hemorrhage. Studies into the pathogenesis of this disease have shed light on the autoantigen (the non-collagenous domain of the alpha3 chain of type IV collagen, alpha3(IV)NC1) and its epitopes, as well as the involvement of autoantibodies and cellular effectors in disease.
Original languageEnglish
Pages (from-to)295 - 300
Number of pages6
JournalJournal of Autoimmunity
Volume31
Issue number3
Publication statusPublished - 2008

Cite this

@article{87930d08763342068534098e48435946,
title = "Advances in the pathogenesis of Goodpasture's disease: From epitopes to autoantibodies to effector T cells",
abstract = "Goodpasture s disease, an organ-specific autoimmune disease is manifest by rapidly progressive glomerulonephritis and pulmonary hemorrhage. Studies into the pathogenesis of this disease have shed light on the autoantigen (the non-collagenous domain of the alpha3 chain of type IV collagen, alpha3(IV)NC1) and its epitopes, as well as the involvement of autoantibodies and cellular effectors in disease.",
author = "Joshua Ooi and Holdsworth, {Stephen Roger} and Kitching, {Arthur Richard}",
year = "2008",
language = "English",
volume = "31",
pages = "295 -- 300",
journal = "Journal of Autoimmunity",
issn = "0896-8411",
publisher = "Elsevier",
number = "3",

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T1 - Advances in the pathogenesis of Goodpasture's disease: From epitopes to autoantibodies to effector T cells

AU - Ooi, Joshua

AU - Holdsworth, Stephen Roger

AU - Kitching, Arthur Richard

PY - 2008

Y1 - 2008

N2 - Goodpasture s disease, an organ-specific autoimmune disease is manifest by rapidly progressive glomerulonephritis and pulmonary hemorrhage. Studies into the pathogenesis of this disease have shed light on the autoantigen (the non-collagenous domain of the alpha3 chain of type IV collagen, alpha3(IV)NC1) and its epitopes, as well as the involvement of autoantibodies and cellular effectors in disease.

AB - Goodpasture s disease, an organ-specific autoimmune disease is manifest by rapidly progressive glomerulonephritis and pulmonary hemorrhage. Studies into the pathogenesis of this disease have shed light on the autoantigen (the non-collagenous domain of the alpha3 chain of type IV collagen, alpha3(IV)NC1) and its epitopes, as well as the involvement of autoantibodies and cellular effectors in disease.

UR - http://www.ncbi.nlm.nih.gov/pubmed/18502098

M3 - Article

VL - 31

SP - 295

EP - 300

JO - Journal of Autoimmunity

JF - Journal of Autoimmunity

SN - 0896-8411

IS - 3

ER -