TY - JOUR
T1 - Advances in structural and molecular neuroimaging in Alzheimer's disease
AU - Ellis, Kathryn A.
AU - Rowe, Christopher C.
AU - Szoeke, Cassandra E.I.
AU - Villemagne, Victor L.
AU - Ames, David
AU - Chételat, Gaël
AU - Martins, Ralph N.
AU - Masters, Colin L.
AU - Fripp, Jurgen
AU - Acosta, Oscar
AU - Raniga, Parnesh
AU - Bourgeat, Pierrick T.
AU - Salvado, Olivier
PY - 2011/2
Y1 - 2011/2
N2 - • Longer life expectancies lead to increases in the prevalence of age-associated illnesses. The number of Australians with dementia is predicted to rise, from 234 000 in 2009 to over 1 million by 2050, as a result of the increased prevalence of Alzheimer's disease (AD), the leading cause of dementia in the elderly. • Early diagnosis of AD will become more important as diseasemodifying therapies emerge within the next decade. • Advances in molecular neuroimaging with amyloid-β-specific radioligands for positron emission tomography, aided by magnetic resonance imaging techniques, allow detection of AD years before symptoms of dementia develop. • Longitudinal prospective studies, such as the Australian Imaging Biomarkers and Lifestyle (AIBL) study of ageing, will determine the sensitivity and specificity of these analysis techniques for diagnosing AD and predicting cognitive decline.
AB - • Longer life expectancies lead to increases in the prevalence of age-associated illnesses. The number of Australians with dementia is predicted to rise, from 234 000 in 2009 to over 1 million by 2050, as a result of the increased prevalence of Alzheimer's disease (AD), the leading cause of dementia in the elderly. • Early diagnosis of AD will become more important as diseasemodifying therapies emerge within the next decade. • Advances in molecular neuroimaging with amyloid-β-specific radioligands for positron emission tomography, aided by magnetic resonance imaging techniques, allow detection of AD years before symptoms of dementia develop. • Longitudinal prospective studies, such as the Australian Imaging Biomarkers and Lifestyle (AIBL) study of ageing, will determine the sensitivity and specificity of these analysis techniques for diagnosing AD and predicting cognitive decline.
UR - http://www.scopus.com/inward/record.url?scp=79952476089&partnerID=8YFLogxK
U2 - 10.5694/j.1326-5377.2011.tb02938.x
DO - 10.5694/j.1326-5377.2011.tb02938.x
M3 - Review Article
C2 - 21401483
AN - SCOPUS:79952476089
SN - 0025-729X
VL - 194
SP - S20-S23
JO - The Medical Journal of Australia
JF - The Medical Journal of Australia
IS - S4
ER -
