Advances in n-3 polyunsaturated fatty acid nutrition

Duo Li, Mark L. Wahlqvist, Andrew J. Sinclair

Research output: Contribution to journalReview ArticleOtherpeer-review

1 Citation (Scopus)

Abstract

There is conclusive evidence to demonstrate the role of omega-3 polyunsaturated fatty acids (n-3 PUFA) in human development and growth, vision, and cell membrane fluidity (membrane order). N-3 PUFA also contribute to human health maintenance through correction of arrhythmias, inhibition of platelet aggregation and prolongation of clotting time, lowering blood pressure, lowering serum triglycerides and plasma homocysteine, being antiinflammatory and immunomodulatory, being cardio-protective, increasing insulin sensitivity in Asians, and decreasing the risk of breast and colorectal cancers. This understanding of a wide spectrum of biological effects attributable to n-3 PUFA has been unsettled by a systematic review of randomized clinical intervention trials (RCTs) which has reported that n-3 PUFA have negligible or no effect on all-cause or cardiovascular mortality. Here, possible reasons for the inconsistencies in regard to n-3 PUFA and cardiovascular diseases, along with the implications for their broader biology, are considered.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalAsia Pacific journal of clinical nutrition
Volume28
Issue number1
DOIs
Publication statusPublished - Mar 2019

Cite this

Li, Duo ; Wahlqvist, Mark L. ; Sinclair, Andrew J. / Advances in n-3 polyunsaturated fatty acid nutrition. In: Asia Pacific journal of clinical nutrition. 2019 ; Vol. 28, No. 1. pp. 1-5.
@article{6a63eb7615ac442cb4b6052867d8de44,
title = "Advances in n-3 polyunsaturated fatty acid nutrition",
abstract = "There is conclusive evidence to demonstrate the role of omega-3 polyunsaturated fatty acids (n-3 PUFA) in human development and growth, vision, and cell membrane fluidity (membrane order). N-3 PUFA also contribute to human health maintenance through correction of arrhythmias, inhibition of platelet aggregation and prolongation of clotting time, lowering blood pressure, lowering serum triglycerides and plasma homocysteine, being antiinflammatory and immunomodulatory, being cardio-protective, increasing insulin sensitivity in Asians, and decreasing the risk of breast and colorectal cancers. This understanding of a wide spectrum of biological effects attributable to n-3 PUFA has been unsettled by a systematic review of randomized clinical intervention trials (RCTs) which has reported that n-3 PUFA have negligible or no effect on all-cause or cardiovascular mortality. Here, possible reasons for the inconsistencies in regard to n-3 PUFA and cardiovascular diseases, along with the implications for their broader biology, are considered.",
author = "Duo Li and Wahlqvist, {Mark L.} and Sinclair, {Andrew J.}",
year = "2019",
month = "3",
doi = "10.6133/apjcn.201903_28(1).0001",
language = "English",
volume = "28",
pages = "1--5",
journal = "Asia Pacific journal of clinical nutrition",
issn = "0964-7058",
publisher = "Wiley-Blackwell",
number = "1",

}

Advances in n-3 polyunsaturated fatty acid nutrition. / Li, Duo; Wahlqvist, Mark L.; Sinclair, Andrew J.

In: Asia Pacific journal of clinical nutrition, Vol. 28, No. 1, 03.2019, p. 1-5.

Research output: Contribution to journalReview ArticleOtherpeer-review

TY - JOUR

T1 - Advances in n-3 polyunsaturated fatty acid nutrition

AU - Li, Duo

AU - Wahlqvist, Mark L.

AU - Sinclair, Andrew J.

PY - 2019/3

Y1 - 2019/3

N2 - There is conclusive evidence to demonstrate the role of omega-3 polyunsaturated fatty acids (n-3 PUFA) in human development and growth, vision, and cell membrane fluidity (membrane order). N-3 PUFA also contribute to human health maintenance through correction of arrhythmias, inhibition of platelet aggregation and prolongation of clotting time, lowering blood pressure, lowering serum triglycerides and plasma homocysteine, being antiinflammatory and immunomodulatory, being cardio-protective, increasing insulin sensitivity in Asians, and decreasing the risk of breast and colorectal cancers. This understanding of a wide spectrum of biological effects attributable to n-3 PUFA has been unsettled by a systematic review of randomized clinical intervention trials (RCTs) which has reported that n-3 PUFA have negligible or no effect on all-cause or cardiovascular mortality. Here, possible reasons for the inconsistencies in regard to n-3 PUFA and cardiovascular diseases, along with the implications for their broader biology, are considered.

AB - There is conclusive evidence to demonstrate the role of omega-3 polyunsaturated fatty acids (n-3 PUFA) in human development and growth, vision, and cell membrane fluidity (membrane order). N-3 PUFA also contribute to human health maintenance through correction of arrhythmias, inhibition of platelet aggregation and prolongation of clotting time, lowering blood pressure, lowering serum triglycerides and plasma homocysteine, being antiinflammatory and immunomodulatory, being cardio-protective, increasing insulin sensitivity in Asians, and decreasing the risk of breast and colorectal cancers. This understanding of a wide spectrum of biological effects attributable to n-3 PUFA has been unsettled by a systematic review of randomized clinical intervention trials (RCTs) which has reported that n-3 PUFA have negligible or no effect on all-cause or cardiovascular mortality. Here, possible reasons for the inconsistencies in regard to n-3 PUFA and cardiovascular diseases, along with the implications for their broader biology, are considered.

UR - http://www.scopus.com/inward/record.url?scp=85063648193&partnerID=8YFLogxK

U2 - 10.6133/apjcn.201903_28(1).0001

DO - 10.6133/apjcn.201903_28(1).0001

M3 - Review Article

VL - 28

SP - 1

EP - 5

JO - Asia Pacific journal of clinical nutrition

JF - Asia Pacific journal of clinical nutrition

SN - 0964-7058

IS - 1

ER -