Abstract
There is conclusive evidence to demonstrate the role of omega-3 polyunsaturated fatty acids (n-3 PUFA) in human development and growth, vision, and cell membrane fluidity (membrane order). N-3 PUFA also contribute to human health maintenance through correction of arrhythmias, inhibition of platelet aggregation and prolongation of clotting time, lowering blood pressure, lowering serum triglycerides and plasma homocysteine, being antiinflammatory and immunomodulatory, being cardio-protective, increasing insulin sensitivity in Asians, and decreasing the risk of breast and colorectal cancers. This understanding of a wide spectrum of biological effects attributable to n-3 PUFA has been unsettled by a systematic review of randomized clinical intervention trials (RCTs) which has reported that n-3 PUFA have negligible or no effect on all-cause or cardiovascular mortality. Here, possible reasons for the inconsistencies in regard to n-3 PUFA and cardiovascular diseases, along with the implications for their broader biology, are considered.
| Original language | English |
|---|---|
| Pages (from-to) | 1-5 |
| Number of pages | 5 |
| Journal | Asia Pacific journal of clinical nutrition |
| Volume | 28 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Mar 2019 |
Cite this
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Advances in n-3 polyunsaturated fatty acid nutrition. / Li, Duo; Wahlqvist, Mark L.; Sinclair, Andrew J.
In: Asia Pacific journal of clinical nutrition, Vol. 28, No. 1, 03.2019, p. 1-5.Research output: Contribution to journal › Review Article › Other › peer-review
TY - JOUR
T1 - Advances in n-3 polyunsaturated fatty acid nutrition
AU - Li, Duo
AU - Wahlqvist, Mark L.
AU - Sinclair, Andrew J.
PY - 2019/3
Y1 - 2019/3
N2 - There is conclusive evidence to demonstrate the role of omega-3 polyunsaturated fatty acids (n-3 PUFA) in human development and growth, vision, and cell membrane fluidity (membrane order). N-3 PUFA also contribute to human health maintenance through correction of arrhythmias, inhibition of platelet aggregation and prolongation of clotting time, lowering blood pressure, lowering serum triglycerides and plasma homocysteine, being antiinflammatory and immunomodulatory, being cardio-protective, increasing insulin sensitivity in Asians, and decreasing the risk of breast and colorectal cancers. This understanding of a wide spectrum of biological effects attributable to n-3 PUFA has been unsettled by a systematic review of randomized clinical intervention trials (RCTs) which has reported that n-3 PUFA have negligible or no effect on all-cause or cardiovascular mortality. Here, possible reasons for the inconsistencies in regard to n-3 PUFA and cardiovascular diseases, along with the implications for their broader biology, are considered.
AB - There is conclusive evidence to demonstrate the role of omega-3 polyunsaturated fatty acids (n-3 PUFA) in human development and growth, vision, and cell membrane fluidity (membrane order). N-3 PUFA also contribute to human health maintenance through correction of arrhythmias, inhibition of platelet aggregation and prolongation of clotting time, lowering blood pressure, lowering serum triglycerides and plasma homocysteine, being antiinflammatory and immunomodulatory, being cardio-protective, increasing insulin sensitivity in Asians, and decreasing the risk of breast and colorectal cancers. This understanding of a wide spectrum of biological effects attributable to n-3 PUFA has been unsettled by a systematic review of randomized clinical intervention trials (RCTs) which has reported that n-3 PUFA have negligible or no effect on all-cause or cardiovascular mortality. Here, possible reasons for the inconsistencies in regard to n-3 PUFA and cardiovascular diseases, along with the implications for their broader biology, are considered.
UR - http://www.scopus.com/inward/record.url?scp=85063648193&partnerID=8YFLogxK
U2 - 10.6133/apjcn.201903_28(1).0001
DO - 10.6133/apjcn.201903_28(1).0001
M3 - Review Article
VL - 28
SP - 1
EP - 5
JO - Asia Pacific journal of clinical nutrition
JF - Asia Pacific journal of clinical nutrition
SN - 0964-7058
IS - 1
ER -