TY - JOUR
T1 - Advances in cosmeceutical nanotechnology for hyperpigmentation treatment
AU - Tangau, Mason Jarius
AU - Chong, Yie Kie
AU - Yeong, Keng Yoon
N1 - Funding Information:
The authors acknowledge the School of Science, Monash University Malaysia for supporting this work.
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/8
Y1 - 2022/8
N2 - Hyperpigmentation is a common and major skin problem that affects people of all skin types. Despite the availability of various depigmentation active ingredients for skin hyperpigmentation disorder, none of them are completely satisfactory due to their poor permeability through the skin layer and significant toxicity, thereby causing severe side effects such as irritative dermatitis, erythema, itching, and skin flaking. Nanotechnology plays an important role in advancing the cosmeceutical formulation by improving the solubility, stability, safety, loading efficiency, and dermal permeability of the active ingredients. The aim of this review is to offer a comprehensive discussion on the application of various nanomaterials in improving cosmeceutical formulations used to treat hyperpigmentation. Focus is placed on elucidating the advantages that nanotechnology can bring to some common hyperpigmentation active ingredients such as hydroquinone, arbutin, kojic acid, azelaic acid, and retinoic acid to improve their efficacy in treating hyperpigmentation. Lastly, a total of 44 reported patents and articles of depigmenting compounds encapsulated by nanoparticles were filed and analyzed. Overall, lipid nanoparticles were found to be the most widely used nanomaterial in treating hyperpigmentation.
AB - Hyperpigmentation is a common and major skin problem that affects people of all skin types. Despite the availability of various depigmentation active ingredients for skin hyperpigmentation disorder, none of them are completely satisfactory due to their poor permeability through the skin layer and significant toxicity, thereby causing severe side effects such as irritative dermatitis, erythema, itching, and skin flaking. Nanotechnology plays an important role in advancing the cosmeceutical formulation by improving the solubility, stability, safety, loading efficiency, and dermal permeability of the active ingredients. The aim of this review is to offer a comprehensive discussion on the application of various nanomaterials in improving cosmeceutical formulations used to treat hyperpigmentation. Focus is placed on elucidating the advantages that nanotechnology can bring to some common hyperpigmentation active ingredients such as hydroquinone, arbutin, kojic acid, azelaic acid, and retinoic acid to improve their efficacy in treating hyperpigmentation. Lastly, a total of 44 reported patents and articles of depigmenting compounds encapsulated by nanoparticles were filed and analyzed. Overall, lipid nanoparticles were found to be the most widely used nanomaterial in treating hyperpigmentation.
KW - Arbutin
KW - Azelaic acid
KW - Cosmeceuticals
KW - Hydroquinone
KW - Hyperpigmentation
KW - Kojic acid
KW - Lipid nanoparticles
KW - Nanomaterials
KW - Retinoic acid
UR - http://www.scopus.com/inward/record.url?scp=85134525072&partnerID=8YFLogxK
U2 - 10.1007/s11051-022-05534-z
DO - 10.1007/s11051-022-05534-z
M3 - Review Article
AN - SCOPUS:85134525072
SN - 1388-0764
VL - 24
JO - Journal of Nanoparticle Research
JF - Journal of Nanoparticle Research
IS - 8
M1 - 155
ER -