@article{742bd3f6fe16456f962e2f5e6685fd55,
title = "Advances in automated cell washing and concentration",
abstract = "The successful commercialization of cell therapies requires thorough planning and consideration of product quality, cost and scale of the manufacturing process. The implementation of automation can be central to a robust and reproducible manufacturing process at industrialized scales. There have been a number of wash-and-concentrate devices developed for cell manufacturing. These technologies have arisen from transfusion medicine, hematopoietic stem cell and biologics manufacturing where operating mechanisms are distinct from manual centrifugation. This review describes the historical origin and fundamental technologies underlying each currently available wash-and-concentrate device as well as their relative advantages and disadvantages in cell therapy applications. Understanding the specific attributes and limitations of these technologies is essential to optimizing cell therapy manufacturing.",
keywords = "automation, bioprocessing, cell manufacturing, cell therapies, devices, stem cells",
author = "Anqi Li and Kusuma, {Gina D.} and Dawn Driscoll and Nathan Smith and Wall, {Dominic M.} and Levine, {Bruce L.} and David James and Rebecca Lim",
note = "Funding Information: This work was supported by the Victorian Government's Operational Infrastructure Support Program and the Victorian Government Technology Voucher provided by the Department of Economic Development, Jobs, Transport and Resources. RL is the recipient of a National Health and Medical Research Council Career Development Fellowship. AL is the recipient of an Australian Postgraduate Research Training Program Scholarship. BLL is a consultant for Novartis and Terumo Medical Corporation; on the scientific advisory board for Avectas, Patheon/Thermo Fisher Scientific Viral Vector Services, Immuneel Therapeutics Private Limited, IN8bio, Ori Biotech and Vycellix; and co-founder of and equity holder in Tmunity Therapeutics. DJ is chief executive officer of Scinogy Pty Ltd. Conception and design of the study: AL, DJ and RL. Acquisition of data: AL. Analysis and interpretation of data: AL, NS and BL. Drafting or revising the manuscript: AL, GK, DD, NS, DW, BL, DJ and RL. All authors have approved the final article. Funding Information: This work was supported by the Victorian Government's Operational Infrastructure Support Program and the Victorian Government Technology Voucher provided by the Department of Economic Development, Jobs, Transport and Resources. RL is the recipient of a National Health and Medical Research Council Career Development Fellowship. AL is the recipient of an Australian Postgraduate Research Training Program Scholarship. Publisher Copyright: {\textcopyright} 2021 International Society for Cell & Gene Therapy Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = sep,
doi = "10.1016/j.jcyt.2021.04.003",
language = "English",
volume = "23",
pages = "774--786",
journal = "Cytotherapy",
issn = "1465-3249",
publisher = "Elsevier",
number = "9",
}
