Advanced materials and nanotechnology for drug delivery

Li Yan, Yang Yang, Wenjun Zhang, Xianfeng Chen

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

Abstract

Many biological barriers are of great importance. For example, stratum corneum, the outmost layer of skin, effectively protects people from being invaded by external microorganisms such as bacteria and viruses. Cell membranes help organisms maintain homeostasis by controlling substances to enter and leave cells. However, on the other hand, these biological barriers seriously restrict drug delivery. For instance, stratum corneum has a very dense structure and only allows very small molecules with a molecular weight of below 500 Da to permeate whereas most drug molecules are much larger than that. A wide variety of drugs including genes needs to enter cells for proper functioning but cell membranes are not permeable to them. To overcome these biological barriers, many drug-delivery routes are being actively researched and developed. In this research news, we will focus on two advanced materials and nanotechnology approaches for delivering vaccines through the skin for painless and efficient immunization and transporting drug molecules to cross cell membranes for high-throughput intracellular delivery.

Original languageEnglish
Pages (from-to)5533-5540
Number of pages8
JournalAdvanced Materials
Volume26
Issue number31
DOIs
Publication statusPublished - 20 Aug 2014
Externally publishedYes

Keywords

  • biological barriers
  • drug delivery
  • microneedle arrays
  • nanoneedle arrays
  • nanostructures
  • nanotechnology

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