TY - JOUR
T1 - Advanced imaging techniques in the diagnosis of nonlesional epilepsy
T2 - MRI, MRS, PET, and SPECT
AU - Pardoe, Heath
AU - Kuzniecky, Ruben
PY - 2014
Y1 - 2014
N2 - Once patients have a diagnosis of localization related epilepsy (LRE), it is critical to further classify those patients into lesional or nonlesional for treatment and prognostic reasons. An individual with LRE may be classified as nonlesional for two reasons: 1) a lesion may not exist; that is, the structural abnormality that gives rise to seizures may be at the channel level or be spatially distributed in such a way that it would not be accurately termed a lesion, or 2) a lesion exists but is so subtle that standard clinical imaging is not sensitive enough to discriminate between the lesion and surrounding healthy brain tissue. As with any technology and disease process, this definition is dynamic, as we know that future imaging techniques will be developed and new disease mechanisms will be discovered, making detection of the epileptogenic underlying abnormality an ever-changing target.
AB - Once patients have a diagnosis of localization related epilepsy (LRE), it is critical to further classify those patients into lesional or nonlesional for treatment and prognostic reasons. An individual with LRE may be classified as nonlesional for two reasons: 1) a lesion may not exist; that is, the structural abnormality that gives rise to seizures may be at the channel level or be spatially distributed in such a way that it would not be accurately termed a lesion, or 2) a lesion exists but is so subtle that standard clinical imaging is not sensitive enough to discriminate between the lesion and surrounding healthy brain tissue. As with any technology and disease process, this definition is dynamic, as we know that future imaging techniques will be developed and new disease mechanisms will be discovered, making detection of the epileptogenic underlying abnormality an ever-changing target.
UR - http://www.scopus.com/inward/record.url?scp=84904605703&partnerID=8YFLogxK
U2 - 10.5698/1535-7597-14.3.121
DO - 10.5698/1535-7597-14.3.121
M3 - Review Article
AN - SCOPUS:84904605703
SN - 1535-7597
VL - 14
SP - 121
EP - 124
JO - Epilepsy Currents
JF - Epilepsy Currents
IS - 3
ER -