TY - JOUR
T1 - Advanced glycation end products (AGEs) are cross-sectionally associated with insulin secretion in healthy subjects
AU - Forbes, Josephine M
AU - Sourris, Karly
AU - De Courten, Maximilian Pangratius J
AU - Dougherty, Sonia L
AU - Chand, Vibhasha
AU - Lyons, Jasmine
AU - Bertovic, David Anthony
AU - Coughlan, Melinda T
AU - Schlaich, Markus Peter
AU - Soldatos, Georgia
AU - Cooper, Mark Emmanuel
AU - Straznicky, Nora
AU - Kingwell, Bronwyn A
AU - de Courten, Barbora
PY - 2014
Y1 - 2014
N2 - It has been postulated that chronic exposure to high levels of advanced glycation end products (AGEs), in particular from dietary sources, can impair insulin secretion. In the present study, we investigated the cross-sectional relationship between AGEs and acute insulin secretion during an intravenous glucose tolerance test (IVGTT) and following a 75 g oral glucose tolerance test (OGTT) in healthy humans. We report the cross-sectional association between circulating AGE concentrations and insulin secretory function in healthy humans (17 F: 27 M, aged 30 ? 10 years) with a wide range of BMI (24.6-31.0 kg/m2). Higher circulating concentrations of AGEs were related to increased first phase insulin secretion during IVGTT (r = 0.43; p <0.05) and lower 2-h glucose concentrations during OGTT (r = -0.31; p <0.05). In addition, fasting (r = -0.36; p <0.05) and 2-h glucose concentrations were negatively related to circulating levels of soluble receptor for AGE (RAGE) isoforms (r = -0.39; p <0.01). In conclusion, in healthy humans, we show a cross-sectional association between advanced glycation end products and acute insulin secretion during glucose tolerance testing.
AB - It has been postulated that chronic exposure to high levels of advanced glycation end products (AGEs), in particular from dietary sources, can impair insulin secretion. In the present study, we investigated the cross-sectional relationship between AGEs and acute insulin secretion during an intravenous glucose tolerance test (IVGTT) and following a 75 g oral glucose tolerance test (OGTT) in healthy humans. We report the cross-sectional association between circulating AGE concentrations and insulin secretory function in healthy humans (17 F: 27 M, aged 30 ? 10 years) with a wide range of BMI (24.6-31.0 kg/m2). Higher circulating concentrations of AGEs were related to increased first phase insulin secretion during IVGTT (r = 0.43; p <0.05) and lower 2-h glucose concentrations during OGTT (r = -0.31; p <0.05). In addition, fasting (r = -0.36; p <0.05) and 2-h glucose concentrations were negatively related to circulating levels of soluble receptor for AGE (RAGE) isoforms (r = -0.39; p <0.01). In conclusion, in healthy humans, we show a cross-sectional association between advanced glycation end products and acute insulin secretion during glucose tolerance testing.
UR - http://link.springer.com/article/10.1007%2Fs00726-013-1542-9
U2 - 10.1007/s00726-013-1542-9
DO - 10.1007/s00726-013-1542-9
M3 - Article
SN - 0939-4451
VL - 46
SP - 321
EP - 326
JO - Amino Acids
JF - Amino Acids
IS - 2
ER -