Adult psychiatric outcomes of very low birth weight survivors

Elizabeth M. Westrupp, Elisabeth Northam, Lex W. Doyle, Catherine Callanan, Peter J. Anderson

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background: Childhood studies have identified relationships between low birth weight and a variety of psychological disorders. However, very few studies have prospectively followed VLBW survivors into adulthood and none have examined adult psychiatric disorders in this population. Objective: This exploratory study sought to determine the rates and nature of psychiatric disorders in very low birth weight (VLBW, birth weight < 1500 g) adults. Method: 117 VLBW participants and 32 normal birth weight (NBW, birth weight > 2499 g) controls, born 1977-1982, were assessed in early adulthood (2429 years). Participants were first screened for psychopathology using the Symptoms Checklist (SCL-90-R). Participants who were elevated on this measure were eligible for a Structured Clinical Interview for DSM-IV-TR (SCID-I/NP) to determine a formal psychiatric diagnosis. Results: VLBW adults were more likely than controls to be elevated on the Global Severity Index (odds ratio (OR) = 4.29, 95% confidence interval (CI) = 0.96, 19.14) and the depression (OR = 5.17, 95%CI = 1.17, 23.00), paranoid ideation (OR = 4.08, 95%CI = 0.91, 18.23), hostility (relative risk (RR) = 1.34, 95%CI = 1.21, 1.49), and interpersonal sensitivity (OR = 3.80, 95%CI = 1.08, 13.32) subscales of the SCL-90-R. VLBW adults were also more likely to be diagnosed with a current mood disorder than NBW adults (RR = 1.36, 95%CI = 1.22, 1.51). Conclusions: VLBW adults are at greater risk of psychopathology than NBW peers.

Original languageEnglish
Pages (from-to)1069-1077
Number of pages9
JournalAustralian & New Zealand Journal of Psychiatry
Volume45
Issue number12
DOIs
Publication statusPublished - Dec 2011
Externally publishedYes

Keywords

  • Adult
  • Longitudinal
  • Perinatal
  • Psychiatric
  • Psychopathology
  • Very low birth weight

Cite this

Westrupp, Elizabeth M. ; Northam, Elisabeth ; Doyle, Lex W. ; Callanan, Catherine ; Anderson, Peter J. / Adult psychiatric outcomes of very low birth weight survivors. In: Australian & New Zealand Journal of Psychiatry. 2011 ; Vol. 45, No. 12. pp. 1069-1077.
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abstract = "Background: Childhood studies have identified relationships between low birth weight and a variety of psychological disorders. However, very few studies have prospectively followed VLBW survivors into adulthood and none have examined adult psychiatric disorders in this population. Objective: This exploratory study sought to determine the rates and nature of psychiatric disorders in very low birth weight (VLBW, birth weight < 1500 g) adults. Method: 117 VLBW participants and 32 normal birth weight (NBW, birth weight > 2499 g) controls, born 1977-1982, were assessed in early adulthood (2429 years). Participants were first screened for psychopathology using the Symptoms Checklist (SCL-90-R). Participants who were elevated on this measure were eligible for a Structured Clinical Interview for DSM-IV-TR (SCID-I/NP) to determine a formal psychiatric diagnosis. Results: VLBW adults were more likely than controls to be elevated on the Global Severity Index (odds ratio (OR) = 4.29, 95{\%} confidence interval (CI) = 0.96, 19.14) and the depression (OR = 5.17, 95{\%}CI = 1.17, 23.00), paranoid ideation (OR = 4.08, 95{\%}CI = 0.91, 18.23), hostility (relative risk (RR) = 1.34, 95{\%}CI = 1.21, 1.49), and interpersonal sensitivity (OR = 3.80, 95{\%}CI = 1.08, 13.32) subscales of the SCL-90-R. VLBW adults were also more likely to be diagnosed with a current mood disorder than NBW adults (RR = 1.36, 95{\%}CI = 1.22, 1.51). Conclusions: VLBW adults are at greater risk of psychopathology than NBW peers.",
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Adult psychiatric outcomes of very low birth weight survivors. / Westrupp, Elizabeth M.; Northam, Elisabeth; Doyle, Lex W.; Callanan, Catherine; Anderson, Peter J.

In: Australian & New Zealand Journal of Psychiatry, Vol. 45, No. 12, 12.2011, p. 1069-1077.

Research output: Contribution to journalArticleResearchpeer-review

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