Adult prostate stem cells

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Abstract

The susceptibility of the prostate to benign prostatic hyperplasia and prostate cancer has prompted research into normal prostate stem cells in order to reveal the underlying mechanisms of these diseases. Yet, it can be challenging to study prostate stem cells because the prostate is a slow cycling tissue. In this chapter, we compare the assays used to study prostate stem cells including castration, lineage tracing and tissue recombination and discuss how they may infl uence the phenotype of stem cells. We also review the location and characteristics of prostate stem cells. In particular, we focus on the evidence for basal and luminal stem cells, the role of intermediate cells as transit amplifying cells and the relationship of neuroendocrine cells to the other epithelial cell types.
Original languageEnglish
Title of host publicationAdult Stem Cells
EditorsKursad Turksen
Place of PublicationUSA
PublisherSpringer
Pages265-286
Number of pages22
Edition2nd
ISBN (Electronic)9781461495697
ISBN (Print)9781461495680
DOIs
Publication statusPublished - 2014

Publication series

NameStem Cell Biology and Regenerative Medicine
PublisherSpringer
ISSN (Print)2196-8985
ISSN (Electronic)2196-8993

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