Adult height is associated with increased risk of ovarian cancer: A Mendelian randomisation study

Suzanne C. Dixon-Suen, Christina M. Nagle, Aaron P. Thrift, Paul D.P. Pharoah, Ailith Ewing, Celeste Leigh Pearce, Wei Zheng, Georgia Chenevix-Trench, Peter A. Fasching, Matthias W. Beckmann, Diether Lambrechts, Ignace Vergote, Sandrina Lambrechts, Els Van Nieuwenhuysen, Mary Anne Rossing, Jennifer A. Doherty, Kristine G. Wicklund, Jenny Chang-Claude, Audrey Y. Jung, Kirsten B. Moysich & 101 others Kunle Odunsi, Marc T. Goodman, Lynne R. Wilkens, Pamela J. Thompson, Yurii B. Shvetsov, Thilo Dörk, Tjoung Won Park-Simon, Peter Hillemanns, Natalia Bogdanova, Ralf Butzow, Heli Nevanlinna, Liisa M. Pelttari, Arto Leminen, Francesmary Modugno, Roberta B. Ness, Robert P. Edwards, Joseph L. Kelley, Florian Heitz, Andreas Du Bois, Philipp Harter, Ira Schwaab, Beth Y. Karlan, Jenny Lester, Sandra Orsulic, Bobbie J. Rimel, Susanne K. Kjær, Estrid Høgdall, Allan Jensen, Ellen L. Goode, Brooke L. Fridley, Julie M. Cunningham, Stacey J. Winham, Graham G. Giles, Fiona Bruinsma, Roger L. Milne, Melissa C. Southey, Michelle A.T. Hildebrandt, Xifeng Wu, Karen H. Lu, Dong Liang, Douglas A. Levine, Maria Bisogna, Joellen M. Schildkraut, Andrew Berchuck, Daniel W. Cramer, Kathryn L. Terry, Elisa V. Bandera, Sara H. Olson, Helga B. Salvesen, Liv Cecilie Vestrheim Thomsen, Reidun K. Kopperud, Line Bjorge, Lambertus A. Kiemeney, Leon F.A.G. Massuger, Tanja Pejovic, Amanda Bruegl, Linda S. Cook, Nhu D. Le, Kenneth D. Swenerton, Angela Brooks-Wilson, Linda E. Kelemen, Jan Lubiński, Tomasz Huzarski, Jacek Gronwald, Janusz Menkiszak, Nicolas Wentzensen, Louise Brinton, Hannah Yang, Jolanta Lissowska, Claus K. Høgdall, Lene Lundvall, Honglin Song, Jonathan P. Tyrer, Ian Campbell, Diana Eccles, James Paul, Rosalind Glasspool, Nadeem Siddiqui, Alice S. Whittemore, Weiva Sieh, Valerie McGuire, Joseph H. Rothstein, Steven A. Narod, Catherine Phelan, Harvey A. Risch, John R. McLaughlin, Hoda Anton-Culver, Argyrios Ziogas, Usha Menon, Simon A. Gayther, Susan J. Ramus, Aleksandra Gentry-Maharaj, Anna H. Wu, Malcolm C. Pike, Chiu Chen Tseng, Jolanta Kupryjanczyk, Agnieszka Dansonka-Mieszkowska, Agnieszka Budzilowska, Iwona K. Rzepecka, Penelope M. Webb, on behalf of the Ovarian Cancer Association Consortium

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background: Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bias. Methods: We pooled data from 39 Ovarian Cancer Association Consortium studies (16,395 cases; 23,003 controls). We applied two-stage predictor-substitution MR, using a weighted genetic risk score combining 609 single-nucleotide polymorphisms. Study-specific odds ratios (OR) and 95% confidence intervals (CI) for the association between genetically predicted height and risk were pooled using random-effects meta-analysis. Results: Greater genetically predicted height was associated with increased ovarian cancer risk overall (pooled-OR (pOR) = 1.06; 95% CI: 1.01-1.11 per 5 cm increase in height), and separately for invasive (pOR = 1.06; 95% CI: 1.01-1.11) and borderline (pOR = 1.15; 95% CI: 1.02-1.29) tumours. Conclusions: Women with a genetic propensity to being taller have increased risk of ovarian cancer. This suggests genes influencing height are involved in pathways promoting ovarian carcinogenesis.

Original languageEnglish
Pages (from-to)1123-1129
Number of pages7
JournalBritish Journal of Cancer
Volume118
Issue number8
DOIs
Publication statusPublished - 1 Apr 2018

Cite this

Dixon-Suen, S. C., Nagle, C. M., Thrift, A. P., Pharoah, P. D. P., Ewing, A., Pearce, C. L., ... on behalf of the Ovarian Cancer Association Consortium (2018). Adult height is associated with increased risk of ovarian cancer: A Mendelian randomisation study. British Journal of Cancer, 118(8), 1123-1129. https://doi.org/10.1038/s41416-018-0011-3
Dixon-Suen, Suzanne C. ; Nagle, Christina M. ; Thrift, Aaron P. ; Pharoah, Paul D.P. ; Ewing, Ailith ; Pearce, Celeste Leigh ; Zheng, Wei ; Chenevix-Trench, Georgia ; Fasching, Peter A. ; Beckmann, Matthias W. ; Lambrechts, Diether ; Vergote, Ignace ; Lambrechts, Sandrina ; Van Nieuwenhuysen, Els ; Rossing, Mary Anne ; Doherty, Jennifer A. ; Wicklund, Kristine G. ; Chang-Claude, Jenny ; Jung, Audrey Y. ; Moysich, Kirsten B. ; Odunsi, Kunle ; Goodman, Marc T. ; Wilkens, Lynne R. ; Thompson, Pamela J. ; Shvetsov, Yurii B. ; Dörk, Thilo ; Park-Simon, Tjoung Won ; Hillemanns, Peter ; Bogdanova, Natalia ; Butzow, Ralf ; Nevanlinna, Heli ; Pelttari, Liisa M. ; Leminen, Arto ; Modugno, Francesmary ; Ness, Roberta B. ; Edwards, Robert P. ; Kelley, Joseph L. ; Heitz, Florian ; Du Bois, Andreas ; Harter, Philipp ; Schwaab, Ira ; Karlan, Beth Y. ; Lester, Jenny ; Orsulic, Sandra ; Rimel, Bobbie J. ; Kjær, Susanne K. ; Høgdall, Estrid ; Jensen, Allan ; Goode, Ellen L. ; Fridley, Brooke L. ; Cunningham, Julie M. ; Winham, Stacey J. ; Giles, Graham G. ; Bruinsma, Fiona ; Milne, Roger L. ; Southey, Melissa C. ; Hildebrandt, Michelle A.T. ; Wu, Xifeng ; Lu, Karen H. ; Liang, Dong ; Levine, Douglas A. ; Bisogna, Maria ; Schildkraut, Joellen M. ; Berchuck, Andrew ; Cramer, Daniel W. ; Terry, Kathryn L. ; Bandera, Elisa V. ; Olson, Sara H. ; Salvesen, Helga B. ; Thomsen, Liv Cecilie Vestrheim ; Kopperud, Reidun K. ; Bjorge, Line ; Kiemeney, Lambertus A. ; Massuger, Leon F.A.G. ; Pejovic, Tanja ; Bruegl, Amanda ; Cook, Linda S. ; Le, Nhu D. ; Swenerton, Kenneth D. ; Brooks-Wilson, Angela ; Kelemen, Linda E. ; Lubiński, Jan ; Huzarski, Tomasz ; Gronwald, Jacek ; Menkiszak, Janusz ; Wentzensen, Nicolas ; Brinton, Louise ; Yang, Hannah ; Lissowska, Jolanta ; Høgdall, Claus K. ; Lundvall, Lene ; Song, Honglin ; Tyrer, Jonathan P. ; Campbell, Ian ; Eccles, Diana ; Paul, James ; Glasspool, Rosalind ; Siddiqui, Nadeem ; Whittemore, Alice S. ; Sieh, Weiva ; McGuire, Valerie ; Rothstein, Joseph H. ; Narod, Steven A. ; Phelan, Catherine ; Risch, Harvey A. ; McLaughlin, John R. ; Anton-Culver, Hoda ; Ziogas, Argyrios ; Menon, Usha ; Gayther, Simon A. ; Ramus, Susan J. ; Gentry-Maharaj, Aleksandra ; Wu, Anna H. ; Pike, Malcolm C. ; Tseng, Chiu Chen ; Kupryjanczyk, Jolanta ; Dansonka-Mieszkowska, Agnieszka ; Budzilowska, Agnieszka ; Rzepecka, Iwona K. ; Webb, Penelope M. ; on behalf of the Ovarian Cancer Association Consortium. / Adult height is associated with increased risk of ovarian cancer : A Mendelian randomisation study. In: British Journal of Cancer. 2018 ; Vol. 118, No. 8. pp. 1123-1129.
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abstract = "Background: Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bias. Methods: We pooled data from 39 Ovarian Cancer Association Consortium studies (16,395 cases; 23,003 controls). We applied two-stage predictor-substitution MR, using a weighted genetic risk score combining 609 single-nucleotide polymorphisms. Study-specific odds ratios (OR) and 95{\%} confidence intervals (CI) for the association between genetically predicted height and risk were pooled using random-effects meta-analysis. Results: Greater genetically predicted height was associated with increased ovarian cancer risk overall (pooled-OR (pOR) = 1.06; 95{\%} CI: 1.01-1.11 per 5 cm increase in height), and separately for invasive (pOR = 1.06; 95{\%} CI: 1.01-1.11) and borderline (pOR = 1.15; 95{\%} CI: 1.02-1.29) tumours. Conclusions: Women with a genetic propensity to being taller have increased risk of ovarian cancer. This suggests genes influencing height are involved in pathways promoting ovarian carcinogenesis.",
author = "Dixon-Suen, {Suzanne C.} and Nagle, {Christina M.} and Thrift, {Aaron P.} and Pharoah, {Paul D.P.} and Ailith Ewing and Pearce, {Celeste Leigh} and Wei Zheng and Georgia Chenevix-Trench and Fasching, {Peter A.} and Beckmann, {Matthias W.} and Diether Lambrechts and Ignace Vergote and Sandrina Lambrechts and {Van Nieuwenhuysen}, Els and Rossing, {Mary Anne} and Doherty, {Jennifer A.} and Wicklund, {Kristine G.} and Jenny Chang-Claude and Jung, {Audrey Y.} and Moysich, {Kirsten B.} and Kunle Odunsi and Goodman, {Marc T.} and Wilkens, {Lynne R.} and Thompson, {Pamela J.} and Shvetsov, {Yurii B.} and Thilo D{\"o}rk and Park-Simon, {Tjoung Won} and Peter Hillemanns and Natalia Bogdanova and Ralf Butzow and Heli Nevanlinna and Pelttari, {Liisa M.} and Arto Leminen and Francesmary Modugno and Ness, {Roberta B.} and Edwards, {Robert P.} and Kelley, {Joseph L.} and Florian Heitz and {Du Bois}, Andreas and Philipp Harter and Ira Schwaab and Karlan, {Beth Y.} and Jenny Lester and Sandra Orsulic and Rimel, {Bobbie J.} and Kj{\ae}r, {Susanne K.} and Estrid H{\o}gdall and Allan Jensen and Goode, {Ellen L.} and Fridley, {Brooke L.} and Cunningham, {Julie M.} and Winham, {Stacey J.} and Giles, {Graham G.} and Fiona Bruinsma and Milne, {Roger L.} and Southey, {Melissa C.} and Hildebrandt, {Michelle A.T.} and Xifeng Wu and Lu, {Karen H.} and Dong Liang and Levine, {Douglas A.} and Maria Bisogna and Schildkraut, {Joellen M.} and Andrew Berchuck and Cramer, {Daniel W.} and Terry, {Kathryn L.} and Bandera, {Elisa V.} and Olson, {Sara H.} and Salvesen, {Helga B.} and Thomsen, {Liv Cecilie Vestrheim} and Kopperud, {Reidun K.} and Line Bjorge and Kiemeney, {Lambertus A.} and Massuger, {Leon F.A.G.} and Tanja Pejovic and Amanda Bruegl and Cook, {Linda S.} and Le, {Nhu D.} and Swenerton, {Kenneth D.} and Angela Brooks-Wilson and Kelemen, {Linda E.} and Jan Lubiński and Tomasz Huzarski and Jacek Gronwald and Janusz Menkiszak and Nicolas Wentzensen and Louise Brinton and Hannah Yang and Jolanta Lissowska and H{\o}gdall, {Claus K.} and Lene Lundvall and Honglin Song and Tyrer, {Jonathan P.} and Ian Campbell and Diana Eccles and James Paul and Rosalind Glasspool and Nadeem Siddiqui and Whittemore, {Alice S.} and Weiva Sieh and Valerie McGuire and Rothstein, {Joseph H.} and Narod, {Steven A.} and Catherine Phelan and Risch, {Harvey A.} and McLaughlin, {John R.} and Hoda Anton-Culver and Argyrios Ziogas and Usha Menon and Gayther, {Simon A.} and Ramus, {Susan J.} and Aleksandra Gentry-Maharaj and Wu, {Anna H.} and Pike, {Malcolm C.} and Tseng, {Chiu Chen} and Jolanta Kupryjanczyk and Agnieszka Dansonka-Mieszkowska and Agnieszka Budzilowska and Rzepecka, {Iwona K.} and Webb, {Penelope M.} and {on behalf of the Ovarian Cancer Association Consortium}",
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language = "English",
volume = "118",
pages = "1123--1129",
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Dixon-Suen, SC, Nagle, CM, Thrift, AP, Pharoah, PDP, Ewing, A, Pearce, CL, Zheng, W, Chenevix-Trench, G, Fasching, PA, Beckmann, MW, Lambrechts, D, Vergote, I, Lambrechts, S, Van Nieuwenhuysen, E, Rossing, MA, Doherty, JA, Wicklund, KG, Chang-Claude, J, Jung, AY, Moysich, KB, Odunsi, K, Goodman, MT, Wilkens, LR, Thompson, PJ, Shvetsov, YB, Dörk, T, Park-Simon, TW, Hillemanns, P, Bogdanova, N, Butzow, R, Nevanlinna, H, Pelttari, LM, Leminen, A, Modugno, F, Ness, RB, Edwards, RP, Kelley, JL, Heitz, F, Du Bois, A, Harter, P, Schwaab, I, Karlan, BY, Lester, J, Orsulic, S, Rimel, BJ, Kjær, SK, Høgdall, E, Jensen, A, Goode, EL, Fridley, BL, Cunningham, JM, Winham, SJ, Giles, GG, Bruinsma, F, Milne, RL, Southey, MC, Hildebrandt, MAT, Wu, X, Lu, KH, Liang, D, Levine, DA, Bisogna, M, Schildkraut, JM, Berchuck, A, Cramer, DW, Terry, KL, Bandera, EV, Olson, SH, Salvesen, HB, Thomsen, LCV, Kopperud, RK, Bjorge, L, Kiemeney, LA, Massuger, LFAG, Pejovic, T, Bruegl, A, Cook, LS, Le, ND, Swenerton, KD, Brooks-Wilson, A, Kelemen, LE, Lubiński, J, Huzarski, T, Gronwald, J, Menkiszak, J, Wentzensen, N, Brinton, L, Yang, H, Lissowska, J, Høgdall, CK, Lundvall, L, Song, H, Tyrer, JP, Campbell, I, Eccles, D, Paul, J, Glasspool, R, Siddiqui, N, Whittemore, AS, Sieh, W, McGuire, V, Rothstein, JH, Narod, SA, Phelan, C, Risch, HA, McLaughlin, JR, Anton-Culver, H, Ziogas, A, Menon, U, Gayther, SA, Ramus, SJ, Gentry-Maharaj, A, Wu, AH, Pike, MC, Tseng, CC, Kupryjanczyk, J, Dansonka-Mieszkowska, A, Budzilowska, A, Rzepecka, IK, Webb, PM & on behalf of the Ovarian Cancer Association Consortium 2018, 'Adult height is associated with increased risk of ovarian cancer: A Mendelian randomisation study' British Journal of Cancer, vol. 118, no. 8, pp. 1123-1129. https://doi.org/10.1038/s41416-018-0011-3

Adult height is associated with increased risk of ovarian cancer : A Mendelian randomisation study. / Dixon-Suen, Suzanne C.; Nagle, Christina M.; Thrift, Aaron P.; Pharoah, Paul D.P.; Ewing, Ailith; Pearce, Celeste Leigh; Zheng, Wei; Chenevix-Trench, Georgia; Fasching, Peter A.; Beckmann, Matthias W.; Lambrechts, Diether; Vergote, Ignace; Lambrechts, Sandrina; Van Nieuwenhuysen, Els; Rossing, Mary Anne; Doherty, Jennifer A.; Wicklund, Kristine G.; Chang-Claude, Jenny; Jung, Audrey Y.; Moysich, Kirsten B.; Odunsi, Kunle; Goodman, Marc T.; Wilkens, Lynne R.; Thompson, Pamela J.; Shvetsov, Yurii B.; Dörk, Thilo; Park-Simon, Tjoung Won; Hillemanns, Peter; Bogdanova, Natalia; Butzow, Ralf; Nevanlinna, Heli; Pelttari, Liisa M.; Leminen, Arto; Modugno, Francesmary; Ness, Roberta B.; Edwards, Robert P.; Kelley, Joseph L.; Heitz, Florian; Du Bois, Andreas; Harter, Philipp; Schwaab, Ira; Karlan, Beth Y.; Lester, Jenny; Orsulic, Sandra; Rimel, Bobbie J.; Kjær, Susanne K.; Høgdall, Estrid; Jensen, Allan; Goode, Ellen L.; Fridley, Brooke L.; Cunningham, Julie M.; Winham, Stacey J.; Giles, Graham G.; Bruinsma, Fiona; Milne, Roger L.; Southey, Melissa C.; Hildebrandt, Michelle A.T.; Wu, Xifeng; Lu, Karen H.; Liang, Dong; Levine, Douglas A.; Bisogna, Maria; Schildkraut, Joellen M.; Berchuck, Andrew; Cramer, Daniel W.; Terry, Kathryn L.; Bandera, Elisa V.; Olson, Sara H.; Salvesen, Helga B.; Thomsen, Liv Cecilie Vestrheim; Kopperud, Reidun K.; Bjorge, Line; Kiemeney, Lambertus A.; Massuger, Leon F.A.G.; Pejovic, Tanja; Bruegl, Amanda; Cook, Linda S.; Le, Nhu D.; Swenerton, Kenneth D.; Brooks-Wilson, Angela; Kelemen, Linda E.; Lubiński, Jan; Huzarski, Tomasz; Gronwald, Jacek; Menkiszak, Janusz; Wentzensen, Nicolas; Brinton, Louise; Yang, Hannah; Lissowska, Jolanta; Høgdall, Claus K.; Lundvall, Lene; Song, Honglin; Tyrer, Jonathan P.; Campbell, Ian; Eccles, Diana; Paul, James; Glasspool, Rosalind; Siddiqui, Nadeem; Whittemore, Alice S.; Sieh, Weiva; McGuire, Valerie; Rothstein, Joseph H.; Narod, Steven A.; Phelan, Catherine; Risch, Harvey A.; McLaughlin, John R.; Anton-Culver, Hoda; Ziogas, Argyrios; Menon, Usha; Gayther, Simon A.; Ramus, Susan J.; Gentry-Maharaj, Aleksandra; Wu, Anna H.; Pike, Malcolm C.; Tseng, Chiu Chen; Kupryjanczyk, Jolanta; Dansonka-Mieszkowska, Agnieszka; Budzilowska, Agnieszka; Rzepecka, Iwona K.; Webb, Penelope M.; on behalf of the Ovarian Cancer Association Consortium.

In: British Journal of Cancer, Vol. 118, No. 8, 01.04.2018, p. 1123-1129.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Adult height is associated with increased risk of ovarian cancer

T2 - A Mendelian randomisation study

AU - Dixon-Suen, Suzanne C.

AU - Nagle, Christina M.

AU - Thrift, Aaron P.

AU - Pharoah, Paul D.P.

AU - Ewing, Ailith

AU - Pearce, Celeste Leigh

AU - Zheng, Wei

AU - Chenevix-Trench, Georgia

AU - Fasching, Peter A.

AU - Beckmann, Matthias W.

AU - Lambrechts, Diether

AU - Vergote, Ignace

AU - Lambrechts, Sandrina

AU - Van Nieuwenhuysen, Els

AU - Rossing, Mary Anne

AU - Doherty, Jennifer A.

AU - Wicklund, Kristine G.

AU - Chang-Claude, Jenny

AU - Jung, Audrey Y.

AU - Moysich, Kirsten B.

AU - Odunsi, Kunle

AU - Goodman, Marc T.

AU - Wilkens, Lynne R.

AU - Thompson, Pamela J.

AU - Shvetsov, Yurii B.

AU - Dörk, Thilo

AU - Park-Simon, Tjoung Won

AU - Hillemanns, Peter

AU - Bogdanova, Natalia

AU - Butzow, Ralf

AU - Nevanlinna, Heli

AU - Pelttari, Liisa M.

AU - Leminen, Arto

AU - Modugno, Francesmary

AU - Ness, Roberta B.

AU - Edwards, Robert P.

AU - Kelley, Joseph L.

AU - Heitz, Florian

AU - Du Bois, Andreas

AU - Harter, Philipp

AU - Schwaab, Ira

AU - Karlan, Beth Y.

AU - Lester, Jenny

AU - Orsulic, Sandra

AU - Rimel, Bobbie J.

AU - Kjær, Susanne K.

AU - Høgdall, Estrid

AU - Jensen, Allan

AU - Goode, Ellen L.

AU - Fridley, Brooke L.

AU - Cunningham, Julie M.

AU - Winham, Stacey J.

AU - Giles, Graham G.

AU - Bruinsma, Fiona

AU - Milne, Roger L.

AU - Southey, Melissa C.

AU - Hildebrandt, Michelle A.T.

AU - Wu, Xifeng

AU - Lu, Karen H.

AU - Liang, Dong

AU - Levine, Douglas A.

AU - Bisogna, Maria

AU - Schildkraut, Joellen M.

AU - Berchuck, Andrew

AU - Cramer, Daniel W.

AU - Terry, Kathryn L.

AU - Bandera, Elisa V.

AU - Olson, Sara H.

AU - Salvesen, Helga B.

AU - Thomsen, Liv Cecilie Vestrheim

AU - Kopperud, Reidun K.

AU - Bjorge, Line

AU - Kiemeney, Lambertus A.

AU - Massuger, Leon F.A.G.

AU - Pejovic, Tanja

AU - Bruegl, Amanda

AU - Cook, Linda S.

AU - Le, Nhu D.

AU - Swenerton, Kenneth D.

AU - Brooks-Wilson, Angela

AU - Kelemen, Linda E.

AU - Lubiński, Jan

AU - Huzarski, Tomasz

AU - Gronwald, Jacek

AU - Menkiszak, Janusz

AU - Wentzensen, Nicolas

AU - Brinton, Louise

AU - Yang, Hannah

AU - Lissowska, Jolanta

AU - Høgdall, Claus K.

AU - Lundvall, Lene

AU - Song, Honglin

AU - Tyrer, Jonathan P.

AU - Campbell, Ian

AU - Eccles, Diana

AU - Paul, James

AU - Glasspool, Rosalind

AU - Siddiqui, Nadeem

AU - Whittemore, Alice S.

AU - Sieh, Weiva

AU - McGuire, Valerie

AU - Rothstein, Joseph H.

AU - Narod, Steven A.

AU - Phelan, Catherine

AU - Risch, Harvey A.

AU - McLaughlin, John R.

AU - Anton-Culver, Hoda

AU - Ziogas, Argyrios

AU - Menon, Usha

AU - Gayther, Simon A.

AU - Ramus, Susan J.

AU - Gentry-Maharaj, Aleksandra

AU - Wu, Anna H.

AU - Pike, Malcolm C.

AU - Tseng, Chiu Chen

AU - Kupryjanczyk, Jolanta

AU - Dansonka-Mieszkowska, Agnieszka

AU - Budzilowska, Agnieszka

AU - Rzepecka, Iwona K.

AU - Webb, Penelope M.

AU - on behalf of the Ovarian Cancer Association Consortium

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Background: Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bias. Methods: We pooled data from 39 Ovarian Cancer Association Consortium studies (16,395 cases; 23,003 controls). We applied two-stage predictor-substitution MR, using a weighted genetic risk score combining 609 single-nucleotide polymorphisms. Study-specific odds ratios (OR) and 95% confidence intervals (CI) for the association between genetically predicted height and risk were pooled using random-effects meta-analysis. Results: Greater genetically predicted height was associated with increased ovarian cancer risk overall (pooled-OR (pOR) = 1.06; 95% CI: 1.01-1.11 per 5 cm increase in height), and separately for invasive (pOR = 1.06; 95% CI: 1.01-1.11) and borderline (pOR = 1.15; 95% CI: 1.02-1.29) tumours. Conclusions: Women with a genetic propensity to being taller have increased risk of ovarian cancer. This suggests genes influencing height are involved in pathways promoting ovarian carcinogenesis.

AB - Background: Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bias. Methods: We pooled data from 39 Ovarian Cancer Association Consortium studies (16,395 cases; 23,003 controls). We applied two-stage predictor-substitution MR, using a weighted genetic risk score combining 609 single-nucleotide polymorphisms. Study-specific odds ratios (OR) and 95% confidence intervals (CI) for the association between genetically predicted height and risk were pooled using random-effects meta-analysis. Results: Greater genetically predicted height was associated with increased ovarian cancer risk overall (pooled-OR (pOR) = 1.06; 95% CI: 1.01-1.11 per 5 cm increase in height), and separately for invasive (pOR = 1.06; 95% CI: 1.01-1.11) and borderline (pOR = 1.15; 95% CI: 1.02-1.29) tumours. Conclusions: Women with a genetic propensity to being taller have increased risk of ovarian cancer. This suggests genes influencing height are involved in pathways promoting ovarian carcinogenesis.

UR - http://www.scopus.com/inward/record.url?scp=85044249910&partnerID=8YFLogxK

U2 - 10.1038/s41416-018-0011-3

DO - 10.1038/s41416-018-0011-3

M3 - Article

VL - 118

SP - 1123

EP - 1129

JO - British Journal of Cancer

JF - British Journal of Cancer

SN - 0007-0920

IS - 8

ER -