Adult height and the risk of cause-specific death and vascular morbidity in 1 million people

Individual participant meta-analysis

David Wormser, Emanuele Di Angelantonio, Stephen Kaptoge, Angela M. Wood, Pei Gao, Qi Sun, Göran Walldius, Randi Selmer, W. M. Monique Verschuren, H. Bas Bueno-de-Mesquita, Gunnar Engström, Paul M. Ridker, Inger Njølstad, Hiroyasu Iso, Ingar Holme, Simona Giampaoli, Hugh Tunstall-Pedoe, J. Michael Gaziano, Eric Brunner, Frank Kee & 246 others Alberto Tosetto, Christa Meisinger, Hermann Brenner, Pierre Ducimetiere, Peter H. Whincup, Robert W. Tipping, Ian Ford, Peter Cremer, Albert Hofman, Lars Wilhelmsen, Robert Clarke, Ian H. de Boer, J. Wouter Jukema, Alejandro Marín Ibañez, Debbie A. Lawlor, Ralph B. D'Agostino, Beatriz Rodriguez, Edoardo Casiglia, Coen D.A. Stehouwer, Leon A. Simons, Paul J. Nietert, Elizabeth Barrett-Connor, Demosthenes B. Panagiotakos, Cecilia Björkelund, Timo E. Strandberg, Sylvia Wassertheil-Smoller, Dan G. Blazer, Tom W. Meade, Lennart Welin, Kurt Svärdsudd, Mark Woodward, Aulikki Nissinen, Daan Kromhout, Torben Jørgensen, Reijo S. Tilvis, Jack M. Guralnik, Annika Rosengren, James O. Taylor, Stefan Kiechl, Gilles R. Dagenais, F. Gerry R. Fowkes, Robert B. Wallace, Kay Tee Khaw, Jonathan A. Shaffer, Marjolein Visser, Jussi Kauhanen, Jukka T. Salonen, John Gallacher, Yoav Ben-Shlomo, Akihiko Kitamura, Johan Sundström, Patrik Wennberg, Yutaka Kiyohara, Makoto Daimon, Agustin Gómez de la Cámara, Jackie A. Cooper, Altan Onat, Richard Devereux, Kenneth J. Mukamal, Rachel Dankner, Matthew W. Knuiman, Carlos J. Crespo, Ron T. Gansevoort, Uri Goldbourt, Børge G. Nordestgaard, Jonathan E. Shaw, Michael Mussolino, Hidaeki Nakagawa, Astrid Fletcher, Lewis H. Kuller, Richard F. Gillum, Vilmundur Gudnason, Gerd Assmann, Nicholas Wald, Pekka R. Jousilahti, Philip Greenland, Maurizio Trevisan, Hanno Ulmer, Adam S. Butterworth, Aaron R. Folsom, George Davey-Smith, Frank B. Hu, John Danesh, Lara M. Simpson, Ingmar Jungner, Ellen W. Demerath, Nora Franceschini, Pamela L. Lutsey, Christos Pitsavos, Christina Chrysohoou, Christodoulos Stefanadis, Robert Atkins, Paul Z. Zimmet, Elizabeth L.M. Barr, S. Goya Wannamethee, Richard W. Morris, Johann Willeit, Siegfried Weger, Friedrich Oberhollenzer, Shah Ebrahim, John W.G. Yarnell, Valérie Tikhonoff, Christina M. Shay, Daniel B. Garside, Susan E. Sutherland, David L. Bachman, Julian E. Keil, Jorge R. Kizer, Bruce M. Psaty, Anne Tybjærg-Hansen, Gorm B. Jensen, Peter Schnohr, Luigi Palmieri, Salvatore Panico, Lorenza Pilotto, Diego Vanuzzo, Judith Simons, John McCallum, Yechiel Friedlander, Caroline L. Phillips, Frank J. Kohout, Joan C. Cornoni-Huntley, Nicholas J. Wareham, Ben Schöttker, Heiko Müller, Dietrich Rothenbacher, Jan Håkan Jansson, Chiara Donfrancesco, Erkki Vartiainen, Kennet Harald, Veikko Salomaa, Ramachandran S. Vasan, Caroline S. Fox, Michael J. Pencina, Toshihide Oizumi, Takamasa Kayama, Takeo Kato, Else Marie Bladbjerg, Lars Møller, Jørgen Jespersen, Angela Chetrit, Flora Lubin, Henry Eriksson, Georgios Lappas, Calle Bengtsson, Lauren Lissner, Dorothea Nagel, Tatu A. Miettinen, Hisatomi Arima, Yasufumi Doi, Toshiharu Ninomiya, Jacqueline M. Dekker, Giel Nijpels, Eric B. Rimm, Walter C. Willett, Kazumasa Yamagishi, Hiroyuki Noda, Sudhir Kurl, Tomi Pekka Tuomainen, Jan L. Poppelaars, Dorly J.H. Deeg, Bianca Lucia De Stavola, Bo Hedblad, Peter Nilsson, Anneke Blokstra, Steven J. Shea, Barbara Thorand, Wolfgang Koenig, Angela Döring, Dorothea Nitsch, Greg Grandits, Aage Tverdal, Wenche Nystad, Joann E. Manson, Susan E. Hankinson, Kenneth A. Bauer, Karina W. Davidson, Susan Kirkland, Daichi Shimbo, Shinichi Sato, Katsuyuki Miura, Masaru Sakurai, Xavier Jouven, Stephan J.L. Bakker, Pim van der Harst, Hans L. Hillege, Mario R. Garcia-Palmieri, Philippe Amouyel, Dominique Arveiler, Jean Ferrières, Helmut Schulte, Anton J.M. de Craen, Naveed Sattar, David J. Stott, Bernard Cantin, Benoît Lamarche, Jean Pierre Després, Jaclyn Bergstrom, Richele R. Bettencourt, Catherine Buisson, Thor Aspelund, Gunnar Sigurdsson, Bolli Thorsson, M. Arfan Ikram, Henning Tiemeier, Jacqueline C.M. Witteman, Roger Tavendale, Gordon D.O. Lowe, Jeun Liang Yeh, Tauqeer Ali, Darren Calhoun, Günay Can, Koshi Nakamura, Yuko Morikawa, Ellisiv B. Mathiesen, Maja Lisa Løchen, Tom Wilsgaard, Erik Ingelsson, Karl Michaëlsson, Tommy Cederholm, Julie Buring, Günter Diem, Hans Concin, Francesco Rodeghiero, Michael Marmot, Martin Shipley Mika Kivimaki, Michele Robertson, Edith Feskens, Johanna M. Geleijnse, Daan Kromhout, Matthew Walker, Sarah Watson, Myriam Alexander, Oscar H. Franco, Reeta Gobin, Philip Haycock, Stephen Kaptoge, Sreenivasa R.Kondapally Seshasai, Sarah Lewington, Lisa Pennells, Eleni Rapsomaniki, Nadeem Sarwar, Alexander Thompson, Simon G. Thompson, Ian R. White, Xiaohui Zhao

Research output: Contribution to journalArticleResearchpeer-review

127 Citations (Scopus)

Abstract

Background: The extent to which adult height, a biomarker of the interplay of genetic endowment and early-life experiences, is related to risk of chronic diseases in adulthood is uncertain. Methods: We calculated hazard ratios (HRs) for height, assessed in increments of 6.5 cm, using individual-participant data on 174 374 deaths or major non-fatal vascular outcomes recorded among 1 085 949 people in 121 prospective studies. Results: For people born between 1900 and 1960, mean adult height increased 0.5-1 cm with each successive decade of birth. After adjustment for age, sex, smoking and year of birth, HRs per 6.5 cm greater height were 0.97 (95% confidence interval: 0.96-0.99) for death from any cause, 0.94 (0.93-0.96) for death from vascular causes, 1.04 (1.03-1.06) for death from cancer and 0.92 (0.90-0.94) for death from other causes. Height was negatively associated with death from coronary disease, stroke subtypes, heart failure, stomach and oral cancers, chronic obstructive pulmonary disease, mental disorders, liver disease and external causes. In contrast, height was positively associated with death from ruptured aortic aneurysm, pulmonary embolism, melanoma and cancers of the pancreas, endocrine and nervous systems, ovary, breast, prostate, colorectum, blood and lung. HRs per 6.5 cm greater height ranged from 1.26 (1.12-1.42) for risk of melanoma death to 0.84 (0.80-0.89) for risk of death from chronic obstructive pulmonary disease. HRs were not appreciably altered after further adjustment for adiposity, blood pressure, lipids, inflammation biomarkers, diabetes mellitus, alcohol consumption or socio-economic indicators. Conclusion: Adult height has directionally opposing relationships with risk of death from several different major causes of chronic diseases. Published by Oxford University Press on behalf of the International Epidemiological Association

Original languageEnglish
Article numberdys086
Pages (from-to)1419-1433
Number of pages15
JournalInternational Journal of Epidemiology
Volume41
Issue number5
DOIs
Publication statusPublished - Oct 2012
Externally publishedYes

Keywords

  • Cancer
  • Cardiovascular disease
  • Cause-specific mortality
  • Epidemiological study
  • Height
  • Meta-analysis

Cite this

Wormser, David ; Di Angelantonio, Emanuele ; Kaptoge, Stephen ; Wood, Angela M. ; Gao, Pei ; Sun, Qi ; Walldius, Göran ; Selmer, Randi ; Monique Verschuren, W. M. ; Bueno-de-Mesquita, H. Bas ; Engström, Gunnar ; Ridker, Paul M. ; Njølstad, Inger ; Iso, Hiroyasu ; Holme, Ingar ; Giampaoli, Simona ; Tunstall-Pedoe, Hugh ; Gaziano, J. Michael ; Brunner, Eric ; Kee, Frank ; Tosetto, Alberto ; Meisinger, Christa ; Brenner, Hermann ; Ducimetiere, Pierre ; Whincup, Peter H. ; Tipping, Robert W. ; Ford, Ian ; Cremer, Peter ; Hofman, Albert ; Wilhelmsen, Lars ; Clarke, Robert ; de Boer, Ian H. ; Jukema, J. Wouter ; Ibañez, Alejandro Marín ; Lawlor, Debbie A. ; D'Agostino, Ralph B. ; Rodriguez, Beatriz ; Casiglia, Edoardo ; Stehouwer, Coen D.A. ; Simons, Leon A. ; Nietert, Paul J. ; Barrett-Connor, Elizabeth ; Panagiotakos, Demosthenes B. ; Björkelund, Cecilia ; Strandberg, Timo E. ; Wassertheil-Smoller, Sylvia ; Blazer, Dan G. ; Meade, Tom W. ; Welin, Lennart ; Svärdsudd, Kurt ; Woodward, Mark ; Nissinen, Aulikki ; Kromhout, Daan ; Jørgensen, Torben ; Tilvis, Reijo S. ; Guralnik, Jack M. ; Rosengren, Annika ; Taylor, James O. ; Kiechl, Stefan ; Dagenais, Gilles R. ; Fowkes, F. Gerry R. ; Wallace, Robert B. ; Khaw, Kay Tee ; Shaffer, Jonathan A. ; Visser, Marjolein ; Kauhanen, Jussi ; Salonen, Jukka T. ; Gallacher, John ; Ben-Shlomo, Yoav ; Kitamura, Akihiko ; Sundström, Johan ; Wennberg, Patrik ; Kiyohara, Yutaka ; Daimon, Makoto ; de la Cámara, Agustin Gómez ; Cooper, Jackie A. ; Onat, Altan ; Devereux, Richard ; Mukamal, Kenneth J. ; Dankner, Rachel ; Knuiman, Matthew W. ; Crespo, Carlos J. ; Gansevoort, Ron T. ; Goldbourt, Uri ; Nordestgaard, Børge G. ; Shaw, Jonathan E. ; Mussolino, Michael ; Nakagawa, Hidaeki ; Fletcher, Astrid ; Kuller, Lewis H. ; Gillum, Richard F. ; Gudnason, Vilmundur ; Assmann, Gerd ; Wald, Nicholas ; Jousilahti, Pekka R. ; Greenland, Philip ; Trevisan, Maurizio ; Ulmer, Hanno ; Butterworth, Adam S. ; Folsom, Aaron R. ; Davey-Smith, George ; Hu, Frank B. ; Danesh, John ; Simpson, Lara M. ; Jungner, Ingmar ; Demerath, Ellen W. ; Franceschini, Nora ; Lutsey, Pamela L. ; Pitsavos, Christos ; Chrysohoou, Christina ; Stefanadis, Christodoulos ; Atkins, Robert ; Zimmet, Paul Z. ; Barr, Elizabeth L.M. ; Wannamethee, S. Goya ; Morris, Richard W. ; Willeit, Johann ; Weger, Siegfried ; Oberhollenzer, Friedrich ; Ebrahim, Shah ; Yarnell, John W.G. ; Tikhonoff, Valérie ; Shay, Christina M. ; Garside, Daniel B. ; Sutherland, Susan E. ; Bachman, David L. ; Keil, Julian E. ; Kizer, Jorge R. ; Psaty, Bruce M. ; Tybjærg-Hansen, Anne ; Jensen, Gorm B. ; Schnohr, Peter ; Palmieri, Luigi ; Panico, Salvatore ; Pilotto, Lorenza ; Vanuzzo, Diego ; Simons, Judith ; McCallum, John ; Friedlander, Yechiel ; Phillips, Caroline L. ; Kohout, Frank J. ; Cornoni-Huntley, Joan C. ; Wareham, Nicholas J. ; Schöttker, Ben ; Müller, Heiko ; Rothenbacher, Dietrich ; Jansson, Jan Håkan ; Donfrancesco, Chiara ; Vartiainen, Erkki ; Harald, Kennet ; Salomaa, Veikko ; Vasan, Ramachandran S. ; Fox, Caroline S. ; Pencina, Michael J. ; Oizumi, Toshihide ; Kayama, Takamasa ; Kato, Takeo ; Bladbjerg, Else Marie ; Møller, Lars ; Jespersen, Jørgen ; Chetrit, Angela ; Lubin, Flora ; Eriksson, Henry ; Lappas, Georgios ; Bengtsson, Calle ; Lissner, Lauren ; Nagel, Dorothea ; Miettinen, Tatu A. ; Arima, Hisatomi ; Doi, Yasufumi ; Ninomiya, Toshiharu ; Dekker, Jacqueline M. ; Nijpels, Giel ; Rimm, Eric B. ; Willett, Walter C. ; Yamagishi, Kazumasa ; Noda, Hiroyuki ; Kurl, Sudhir ; Tuomainen, Tomi Pekka ; Poppelaars, Jan L. ; Deeg, Dorly J.H. ; De Stavola, Bianca Lucia ; Hedblad, Bo ; Nilsson, Peter ; Blokstra, Anneke ; Shea, Steven J. ; Thorand, Barbara ; Koenig, Wolfgang ; Döring, Angela ; Nitsch, Dorothea ; Grandits, Greg ; Tverdal, Aage ; Nystad, Wenche ; Manson, Joann E. ; Hankinson, Susan E. ; Bauer, Kenneth A. ; Davidson, Karina W. ; Kirkland, Susan ; Shimbo, Daichi ; Sato, Shinichi ; Miura, Katsuyuki ; Sakurai, Masaru ; Jouven, Xavier ; Bakker, Stephan J.L. ; van der Harst, Pim ; Hillege, Hans L. ; Garcia-Palmieri, Mario R. ; Amouyel, Philippe ; Arveiler, Dominique ; Ferrières, Jean ; Schulte, Helmut ; de Craen, Anton J.M. ; Sattar, Naveed ; Stott, David J. ; Cantin, Bernard ; Lamarche, Benoît ; Després, Jean Pierre ; Bergstrom, Jaclyn ; Bettencourt, Richele R. ; Buisson, Catherine ; Aspelund, Thor ; Sigurdsson, Gunnar ; Thorsson, Bolli ; Ikram, M. Arfan ; Tiemeier, Henning ; Witteman, Jacqueline C.M. ; Tavendale, Roger ; Lowe, Gordon D.O. ; Yeh, Jeun Liang ; Ali, Tauqeer ; Calhoun, Darren ; Can, Günay ; Nakamura, Koshi ; Morikawa, Yuko ; Mathiesen, Ellisiv B. ; Løchen, Maja Lisa ; Wilsgaard, Tom ; Ingelsson, Erik ; Michaëlsson, Karl ; Cederholm, Tommy ; Buring, Julie ; Diem, Günter ; Concin, Hans ; Rodeghiero, Francesco ; Marmot, Michael ; Kivimaki, Martin Shipley Mika ; Robertson, Michele ; Feskens, Edith ; Geleijnse, Johanna M. ; Kromhout, Daan ; Walker, Matthew ; Watson, Sarah ; Alexander, Myriam ; Franco, Oscar H. ; Gobin, Reeta ; Haycock, Philip ; Kaptoge, Stephen ; Seshasai, Sreenivasa R.Kondapally ; Lewington, Sarah ; Pennells, Lisa ; Rapsomaniki, Eleni ; Sarwar, Nadeem ; Thompson, Alexander ; Thompson, Simon G. ; White, Ian R. ; Zhao, Xiaohui. / Adult height and the risk of cause-specific death and vascular morbidity in 1 million people : Individual participant meta-analysis. In: International Journal of Epidemiology. 2012 ; Vol. 41, No. 5. pp. 1419-1433.
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title = "Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: Individual participant meta-analysis",
abstract = "Background: The extent to which adult height, a biomarker of the interplay of genetic endowment and early-life experiences, is related to risk of chronic diseases in adulthood is uncertain. Methods: We calculated hazard ratios (HRs) for height, assessed in increments of 6.5 cm, using individual-participant data on 174 374 deaths or major non-fatal vascular outcomes recorded among 1 085 949 people in 121 prospective studies. Results: For people born between 1900 and 1960, mean adult height increased 0.5-1 cm with each successive decade of birth. After adjustment for age, sex, smoking and year of birth, HRs per 6.5 cm greater height were 0.97 (95{\%} confidence interval: 0.96-0.99) for death from any cause, 0.94 (0.93-0.96) for death from vascular causes, 1.04 (1.03-1.06) for death from cancer and 0.92 (0.90-0.94) for death from other causes. Height was negatively associated with death from coronary disease, stroke subtypes, heart failure, stomach and oral cancers, chronic obstructive pulmonary disease, mental disorders, liver disease and external causes. In contrast, height was positively associated with death from ruptured aortic aneurysm, pulmonary embolism, melanoma and cancers of the pancreas, endocrine and nervous systems, ovary, breast, prostate, colorectum, blood and lung. HRs per 6.5 cm greater height ranged from 1.26 (1.12-1.42) for risk of melanoma death to 0.84 (0.80-0.89) for risk of death from chronic obstructive pulmonary disease. HRs were not appreciably altered after further adjustment for adiposity, blood pressure, lipids, inflammation biomarkers, diabetes mellitus, alcohol consumption or socio-economic indicators. Conclusion: Adult height has directionally opposing relationships with risk of death from several different major causes of chronic diseases. Published by Oxford University Press on behalf of the International Epidemiological Association",
keywords = "Cancer, Cardiovascular disease, Cause-specific mortality, Epidemiological study, Height, Meta-analysis",
author = "David Wormser and {Di Angelantonio}, Emanuele and Stephen Kaptoge and Wood, {Angela M.} and Pei Gao and Qi Sun and G{\"o}ran Walldius and Randi Selmer and {Monique Verschuren}, {W. M.} and Bueno-de-Mesquita, {H. Bas} and Gunnar Engstr{\"o}m and Ridker, {Paul M.} and Inger Nj{\o}lstad and Hiroyasu Iso and Ingar Holme and Simona Giampaoli and Hugh Tunstall-Pedoe and Gaziano, {J. Michael} and Eric Brunner and Frank Kee and Alberto Tosetto and Christa Meisinger and Hermann Brenner and Pierre Ducimetiere and Whincup, {Peter H.} and Tipping, {Robert W.} and Ian Ford and Peter Cremer and Albert Hofman and Lars Wilhelmsen and Robert Clarke and {de Boer}, {Ian H.} and Jukema, {J. Wouter} and Iba{\~n}ez, {Alejandro Mar{\'i}n} and Lawlor, {Debbie A.} and D'Agostino, {Ralph B.} and Beatriz Rodriguez and Edoardo Casiglia and Stehouwer, {Coen D.A.} and Simons, {Leon A.} and Nietert, {Paul J.} and Elizabeth Barrett-Connor and Panagiotakos, {Demosthenes B.} and Cecilia Bj{\"o}rkelund and Strandberg, {Timo E.} and Sylvia Wassertheil-Smoller and Blazer, {Dan G.} and Meade, {Tom W.} and Lennart Welin and Kurt Sv{\"a}rdsudd and Mark Woodward and Aulikki Nissinen and Daan Kromhout and Torben J{\o}rgensen and Tilvis, {Reijo S.} and Guralnik, {Jack M.} and Annika Rosengren and Taylor, {James O.} and Stefan Kiechl and Dagenais, {Gilles R.} and Fowkes, {F. Gerry R.} and Wallace, {Robert B.} and Khaw, {Kay Tee} and Shaffer, {Jonathan A.} and Marjolein Visser and Jussi Kauhanen and Salonen, {Jukka T.} and John Gallacher and Yoav Ben-Shlomo and Akihiko Kitamura and Johan Sundstr{\"o}m and Patrik Wennberg and Yutaka Kiyohara and Makoto Daimon and {de la C{\'a}mara}, {Agustin G{\'o}mez} and Cooper, {Jackie A.} and Altan Onat and Richard Devereux and Mukamal, {Kenneth J.} and Rachel Dankner and Knuiman, {Matthew W.} and Crespo, {Carlos J.} and Gansevoort, {Ron T.} and Uri Goldbourt and Nordestgaard, {B{\o}rge G.} and Shaw, {Jonathan E.} and Michael Mussolino and Hidaeki Nakagawa and Astrid Fletcher and Kuller, {Lewis H.} and Gillum, {Richard F.} and Vilmundur Gudnason and Gerd Assmann and Nicholas Wald and Jousilahti, {Pekka R.} and Philip Greenland and Maurizio Trevisan and Hanno Ulmer and Butterworth, {Adam S.} and Folsom, {Aaron R.} and George Davey-Smith and Hu, {Frank B.} and John Danesh and Simpson, {Lara M.} and Ingmar Jungner and Demerath, {Ellen W.} and Nora Franceschini and Lutsey, {Pamela L.} and Christos Pitsavos and Christina Chrysohoou and Christodoulos Stefanadis and Robert Atkins and Zimmet, {Paul Z.} and Barr, {Elizabeth L.M.} and Wannamethee, {S. Goya} and Morris, {Richard W.} and Johann Willeit and Siegfried Weger and Friedrich Oberhollenzer and Shah Ebrahim and Yarnell, {John W.G.} and Val{\'e}rie Tikhonoff and Shay, {Christina M.} and Garside, {Daniel B.} and Sutherland, {Susan E.} and Bachman, {David L.} and Keil, {Julian E.} and Kizer, {Jorge R.} and Psaty, {Bruce M.} and Anne Tybj{\ae}rg-Hansen and Jensen, {Gorm B.} and Peter Schnohr and Luigi Palmieri and Salvatore Panico and Lorenza Pilotto and Diego Vanuzzo and Judith Simons and John McCallum and Yechiel Friedlander and Phillips, {Caroline L.} and Kohout, {Frank J.} and Cornoni-Huntley, {Joan C.} and Wareham, {Nicholas J.} and Ben Sch{\"o}ttker and Heiko M{\"u}ller and Dietrich Rothenbacher and Jansson, {Jan H{\aa}kan} and Chiara Donfrancesco and Erkki Vartiainen and Kennet Harald and Veikko Salomaa and Vasan, {Ramachandran S.} and Fox, {Caroline S.} and Pencina, {Michael J.} and Toshihide Oizumi and Takamasa Kayama and Takeo Kato and Bladbjerg, {Else Marie} and Lars M{\o}ller and J{\o}rgen Jespersen and Angela Chetrit and Flora Lubin and Henry Eriksson and Georgios Lappas and Calle Bengtsson and Lauren Lissner and Dorothea Nagel and Miettinen, {Tatu A.} and Hisatomi Arima and Yasufumi Doi and Toshiharu Ninomiya and Dekker, {Jacqueline M.} and Giel Nijpels and Rimm, {Eric B.} and Willett, {Walter C.} and Kazumasa Yamagishi and Hiroyuki Noda and Sudhir Kurl and Tuomainen, {Tomi Pekka} and Poppelaars, {Jan L.} and Deeg, {Dorly J.H.} and {De Stavola}, {Bianca Lucia} and Bo Hedblad and Peter Nilsson and Anneke Blokstra and Shea, {Steven J.} and Barbara Thorand and Wolfgang Koenig and Angela D{\"o}ring and Dorothea Nitsch and Greg Grandits and Aage Tverdal and Wenche Nystad and Manson, {Joann E.} and Hankinson, {Susan E.} and Bauer, {Kenneth A.} and Davidson, {Karina W.} and Susan Kirkland and Daichi Shimbo and Shinichi Sato and Katsuyuki Miura and Masaru Sakurai and Xavier Jouven and Bakker, {Stephan J.L.} and {van der Harst}, Pim and Hillege, {Hans L.} and Garcia-Palmieri, {Mario R.} and Philippe Amouyel and Dominique Arveiler and Jean Ferri{\`e}res and Helmut Schulte and {de Craen}, {Anton J.M.} and Naveed Sattar and Stott, {David J.} and Bernard Cantin and Beno{\^i}t Lamarche and Despr{\'e}s, {Jean Pierre} and Jaclyn Bergstrom and Bettencourt, {Richele R.} and Catherine Buisson and Thor Aspelund and Gunnar Sigurdsson and Bolli Thorsson and Ikram, {M. Arfan} and Henning Tiemeier and Witteman, {Jacqueline C.M.} and Roger Tavendale and Lowe, {Gordon D.O.} and Yeh, {Jeun Liang} and Tauqeer Ali and Darren Calhoun and G{\"u}nay Can and Koshi Nakamura and Yuko Morikawa and Mathiesen, {Ellisiv B.} and L{\o}chen, {Maja Lisa} and Tom Wilsgaard and Erik Ingelsson and Karl Micha{\"e}lsson and Tommy Cederholm and Julie Buring and G{\"u}nter Diem and Hans Concin and Francesco Rodeghiero and Michael Marmot and Kivimaki, {Martin Shipley Mika} and Michele Robertson and Edith Feskens and Geleijnse, {Johanna M.} and Daan Kromhout and Matthew Walker and Sarah Watson and Myriam Alexander and Franco, {Oscar H.} and Reeta Gobin and Philip Haycock and Stephen Kaptoge and Seshasai, {Sreenivasa R.Kondapally} and Sarah Lewington and Lisa Pennells and Eleni Rapsomaniki and Nadeem Sarwar and Alexander Thompson and Thompson, {Simon G.} and White, {Ian R.} and Xiaohui Zhao",
year = "2012",
month = "10",
doi = "10.1093/ije/dys086",
language = "English",
volume = "41",
pages = "1419--1433",
journal = "International Journal of Epidemiology",
issn = "0300-5771",
publisher = "Oxford University Press",
number = "5",

}

Wormser, D, Di Angelantonio, E, Kaptoge, S, Wood, AM, Gao, P, Sun, Q, Walldius, G, Selmer, R, Monique Verschuren, WM, Bueno-de-Mesquita, HB, Engström, G, Ridker, PM, Njølstad, I, Iso, H, Holme, I, Giampaoli, S, Tunstall-Pedoe, H, Gaziano, JM, Brunner, E, Kee, F, Tosetto, A, Meisinger, C, Brenner, H, Ducimetiere, P, Whincup, PH, Tipping, RW, Ford, I, Cremer, P, Hofman, A, Wilhelmsen, L, Clarke, R, de Boer, IH, Jukema, JW, Ibañez, AM, Lawlor, DA, D'Agostino, RB, Rodriguez, B, Casiglia, E, Stehouwer, CDA, Simons, LA, Nietert, PJ, Barrett-Connor, E, Panagiotakos, DB, Björkelund, C, Strandberg, TE, Wassertheil-Smoller, S, Blazer, DG, Meade, TW, Welin, L, Svärdsudd, K, Woodward, M, Nissinen, A, Kromhout, D, Jørgensen, T, Tilvis, RS, Guralnik, JM, Rosengren, A, Taylor, JO, Kiechl, S, Dagenais, GR, Fowkes, FGR, Wallace, RB, Khaw, KT, Shaffer, JA, Visser, M, Kauhanen, J, Salonen, JT, Gallacher, J, Ben-Shlomo, Y, Kitamura, A, Sundström, J, Wennberg, P, Kiyohara, Y, Daimon, M, de la Cámara, AG, Cooper, JA, Onat, A, Devereux, R, Mukamal, KJ, Dankner, R, Knuiman, MW, Crespo, CJ, Gansevoort, RT, Goldbourt, U, Nordestgaard, BG, Shaw, JE, Mussolino, M, Nakagawa, H, Fletcher, A, Kuller, LH, Gillum, RF, Gudnason, V, Assmann, G, Wald, N, Jousilahti, PR, Greenland, P, Trevisan, M, Ulmer, H, Butterworth, AS, Folsom, AR, Davey-Smith, G, Hu, FB, Danesh, J, Simpson, LM, Jungner, I, Demerath, EW, Franceschini, N, Lutsey, PL, Pitsavos, C, Chrysohoou, C, Stefanadis, C, Atkins, R, Zimmet, PZ, Barr, ELM, Wannamethee, SG, Morris, RW, Willeit, J, Weger, S, Oberhollenzer, F, Ebrahim, S, Yarnell, JWG, Tikhonoff, V, Shay, CM, Garside, DB, Sutherland, SE, Bachman, DL, Keil, JE, Kizer, JR, Psaty, BM, Tybjærg-Hansen, A, Jensen, GB, Schnohr, P, Palmieri, L, Panico, S, Pilotto, L, Vanuzzo, D, Simons, J, McCallum, J, Friedlander, Y, Phillips, CL, Kohout, FJ, Cornoni-Huntley, JC, Wareham, NJ, Schöttker, B, Müller, H, Rothenbacher, D, Jansson, JH, Donfrancesco, C, Vartiainen, E, Harald, K, Salomaa, V, Vasan, RS, Fox, CS, Pencina, MJ, Oizumi, T, Kayama, T, Kato, T, Bladbjerg, EM, Møller, L, Jespersen, J, Chetrit, A, Lubin, F, Eriksson, H, Lappas, G, Bengtsson, C, Lissner, L, Nagel, D, Miettinen, TA, Arima, H, Doi, Y, Ninomiya, T, Dekker, JM, Nijpels, G, Rimm, EB, Willett, WC, Yamagishi, K, Noda, H, Kurl, S, Tuomainen, TP, Poppelaars, JL, Deeg, DJH, De Stavola, BL, Hedblad, B, Nilsson, P, Blokstra, A, Shea, SJ, Thorand, B, Koenig, W, Döring, A, Nitsch, D, Grandits, G, Tverdal, A, Nystad, W, Manson, JE, Hankinson, SE, Bauer, KA, Davidson, KW, Kirkland, S, Shimbo, D, Sato, S, Miura, K, Sakurai, M, Jouven, X, Bakker, SJL, van der Harst, P, Hillege, HL, Garcia-Palmieri, MR, Amouyel, P, Arveiler, D, Ferrières, J, Schulte, H, de Craen, AJM, Sattar, N, Stott, DJ, Cantin, B, Lamarche, B, Després, JP, Bergstrom, J, Bettencourt, RR, Buisson, C, Aspelund, T, Sigurdsson, G, Thorsson, B, Ikram, MA, Tiemeier, H, Witteman, JCM, Tavendale, R, Lowe, GDO, Yeh, JL, Ali, T, Calhoun, D, Can, G, Nakamura, K, Morikawa, Y, Mathiesen, EB, Løchen, ML, Wilsgaard, T, Ingelsson, E, Michaëlsson, K, Cederholm, T, Buring, J, Diem, G, Concin, H, Rodeghiero, F, Marmot, M, Kivimaki, MSM, Robertson, M, Feskens, E, Geleijnse, JM, Kromhout, D, Walker, M, Watson, S, Alexander, M, Franco, OH, Gobin, R, Haycock, P, Kaptoge, S, Seshasai, SRK, Lewington, S, Pennells, L, Rapsomaniki, E, Sarwar, N, Thompson, A, Thompson, SG, White, IR & Zhao, X 2012, 'Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: Individual participant meta-analysis', International Journal of Epidemiology, vol. 41, no. 5, dys086, pp. 1419-1433. https://doi.org/10.1093/ije/dys086

Adult height and the risk of cause-specific death and vascular morbidity in 1 million people : Individual participant meta-analysis. / Wormser, David; Di Angelantonio, Emanuele; Kaptoge, Stephen; Wood, Angela M.; Gao, Pei; Sun, Qi; Walldius, Göran; Selmer, Randi; Monique Verschuren, W. M.; Bueno-de-Mesquita, H. Bas; Engström, Gunnar; Ridker, Paul M.; Njølstad, Inger; Iso, Hiroyasu; Holme, Ingar; Giampaoli, Simona; Tunstall-Pedoe, Hugh; Gaziano, J. Michael; Brunner, Eric; Kee, Frank; Tosetto, Alberto; Meisinger, Christa; Brenner, Hermann; Ducimetiere, Pierre; Whincup, Peter H.; Tipping, Robert W.; Ford, Ian; Cremer, Peter; Hofman, Albert; Wilhelmsen, Lars; Clarke, Robert; de Boer, Ian H.; Jukema, J. Wouter; Ibañez, Alejandro Marín; Lawlor, Debbie A.; D'Agostino, Ralph B.; Rodriguez, Beatriz; Casiglia, Edoardo; Stehouwer, Coen D.A.; Simons, Leon A.; Nietert, Paul J.; Barrett-Connor, Elizabeth; Panagiotakos, Demosthenes B.; Björkelund, Cecilia; Strandberg, Timo E.; Wassertheil-Smoller, Sylvia; Blazer, Dan G.; Meade, Tom W.; Welin, Lennart; Svärdsudd, Kurt; Woodward, Mark; Nissinen, Aulikki; Kromhout, Daan; Jørgensen, Torben; Tilvis, Reijo S.; Guralnik, Jack M.; Rosengren, Annika; Taylor, James O.; Kiechl, Stefan; Dagenais, Gilles R.; Fowkes, F. Gerry R.; Wallace, Robert B.; Khaw, Kay Tee; Shaffer, Jonathan A.; Visser, Marjolein; Kauhanen, Jussi; Salonen, Jukka T.; Gallacher, John; Ben-Shlomo, Yoav; Kitamura, Akihiko; Sundström, Johan; Wennberg, Patrik; Kiyohara, Yutaka; Daimon, Makoto; de la Cámara, Agustin Gómez; Cooper, Jackie A.; Onat, Altan; Devereux, Richard; Mukamal, Kenneth J.; Dankner, Rachel; Knuiman, Matthew W.; Crespo, Carlos J.; Gansevoort, Ron T.; Goldbourt, Uri; Nordestgaard, Børge G.; Shaw, Jonathan E.; Mussolino, Michael; Nakagawa, Hidaeki; Fletcher, Astrid; Kuller, Lewis H.; Gillum, Richard F.; Gudnason, Vilmundur; Assmann, Gerd; Wald, Nicholas; Jousilahti, Pekka R.; Greenland, Philip; Trevisan, Maurizio; Ulmer, Hanno; Butterworth, Adam S.; Folsom, Aaron R.; Davey-Smith, George; Hu, Frank B.; Danesh, John; Simpson, Lara M.; Jungner, Ingmar; Demerath, Ellen W.; Franceschini, Nora; Lutsey, Pamela L.; Pitsavos, Christos; Chrysohoou, Christina; Stefanadis, Christodoulos; Atkins, Robert; Zimmet, Paul Z.; Barr, Elizabeth L.M.; Wannamethee, S. Goya; Morris, Richard W.; Willeit, Johann; Weger, Siegfried; Oberhollenzer, Friedrich; Ebrahim, Shah; Yarnell, John W.G.; Tikhonoff, Valérie; Shay, Christina M.; Garside, Daniel B.; Sutherland, Susan E.; Bachman, David L.; Keil, Julian E.; Kizer, Jorge R.; Psaty, Bruce M.; Tybjærg-Hansen, Anne; Jensen, Gorm B.; Schnohr, Peter; Palmieri, Luigi; Panico, Salvatore; Pilotto, Lorenza; Vanuzzo, Diego; Simons, Judith; McCallum, John; Friedlander, Yechiel; Phillips, Caroline L.; Kohout, Frank J.; Cornoni-Huntley, Joan C.; Wareham, Nicholas J.; Schöttker, Ben; Müller, Heiko; Rothenbacher, Dietrich; Jansson, Jan Håkan; Donfrancesco, Chiara; Vartiainen, Erkki; Harald, Kennet; Salomaa, Veikko; Vasan, Ramachandran S.; Fox, Caroline S.; Pencina, Michael J.; Oizumi, Toshihide; Kayama, Takamasa; Kato, Takeo; Bladbjerg, Else Marie; Møller, Lars; Jespersen, Jørgen; Chetrit, Angela; Lubin, Flora; Eriksson, Henry; Lappas, Georgios; Bengtsson, Calle; Lissner, Lauren; Nagel, Dorothea; Miettinen, Tatu A.; Arima, Hisatomi; Doi, Yasufumi; Ninomiya, Toshiharu; Dekker, Jacqueline M.; Nijpels, Giel; Rimm, Eric B.; Willett, Walter C.; Yamagishi, Kazumasa; Noda, Hiroyuki; Kurl, Sudhir; Tuomainen, Tomi Pekka; Poppelaars, Jan L.; Deeg, Dorly J.H.; De Stavola, Bianca Lucia; Hedblad, Bo; Nilsson, Peter; Blokstra, Anneke; Shea, Steven J.; Thorand, Barbara; Koenig, Wolfgang; Döring, Angela; Nitsch, Dorothea; Grandits, Greg; Tverdal, Aage; Nystad, Wenche; Manson, Joann E.; Hankinson, Susan E.; Bauer, Kenneth A.; Davidson, Karina W.; Kirkland, Susan; Shimbo, Daichi; Sato, Shinichi; Miura, Katsuyuki; Sakurai, Masaru; Jouven, Xavier; Bakker, Stephan J.L.; van der Harst, Pim; Hillege, Hans L.; Garcia-Palmieri, Mario R.; Amouyel, Philippe; Arveiler, Dominique; Ferrières, Jean; Schulte, Helmut; de Craen, Anton J.M.; Sattar, Naveed; Stott, David J.; Cantin, Bernard; Lamarche, Benoît; Després, Jean Pierre; Bergstrom, Jaclyn; Bettencourt, Richele R.; Buisson, Catherine; Aspelund, Thor; Sigurdsson, Gunnar; Thorsson, Bolli; Ikram, M. Arfan; Tiemeier, Henning; Witteman, Jacqueline C.M.; Tavendale, Roger; Lowe, Gordon D.O.; Yeh, Jeun Liang; Ali, Tauqeer; Calhoun, Darren; Can, Günay; Nakamura, Koshi; Morikawa, Yuko; Mathiesen, Ellisiv B.; Løchen, Maja Lisa; Wilsgaard, Tom; Ingelsson, Erik; Michaëlsson, Karl; Cederholm, Tommy; Buring, Julie; Diem, Günter; Concin, Hans; Rodeghiero, Francesco; Marmot, Michael; Kivimaki, Martin Shipley Mika; Robertson, Michele; Feskens, Edith; Geleijnse, Johanna M.; Kromhout, Daan; Walker, Matthew; Watson, Sarah; Alexander, Myriam; Franco, Oscar H.; Gobin, Reeta; Haycock, Philip; Kaptoge, Stephen; Seshasai, Sreenivasa R.Kondapally; Lewington, Sarah; Pennells, Lisa; Rapsomaniki, Eleni; Sarwar, Nadeem; Thompson, Alexander; Thompson, Simon G.; White, Ian R.; Zhao, Xiaohui.

In: International Journal of Epidemiology, Vol. 41, No. 5, dys086, 10.2012, p. 1419-1433.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Adult height and the risk of cause-specific death and vascular morbidity in 1 million people

T2 - Individual participant meta-analysis

AU - Wormser, David

AU - Di Angelantonio, Emanuele

AU - Kaptoge, Stephen

AU - Wood, Angela M.

AU - Gao, Pei

AU - Sun, Qi

AU - Walldius, Göran

AU - Selmer, Randi

AU - Monique Verschuren, W. M.

AU - Bueno-de-Mesquita, H. Bas

AU - Engström, Gunnar

AU - Ridker, Paul M.

AU - Njølstad, Inger

AU - Iso, Hiroyasu

AU - Holme, Ingar

AU - Giampaoli, Simona

AU - Tunstall-Pedoe, Hugh

AU - Gaziano, J. Michael

AU - Brunner, Eric

AU - Kee, Frank

AU - Tosetto, Alberto

AU - Meisinger, Christa

AU - Brenner, Hermann

AU - Ducimetiere, Pierre

AU - Whincup, Peter H.

AU - Tipping, Robert W.

AU - Ford, Ian

AU - Cremer, Peter

AU - Hofman, Albert

AU - Wilhelmsen, Lars

AU - Clarke, Robert

AU - de Boer, Ian H.

AU - Jukema, J. Wouter

AU - Ibañez, Alejandro Marín

AU - Lawlor, Debbie A.

AU - D'Agostino, Ralph B.

AU - Rodriguez, Beatriz

AU - Casiglia, Edoardo

AU - Stehouwer, Coen D.A.

AU - Simons, Leon A.

AU - Nietert, Paul J.

AU - Barrett-Connor, Elizabeth

AU - Panagiotakos, Demosthenes B.

AU - Björkelund, Cecilia

AU - Strandberg, Timo E.

AU - Wassertheil-Smoller, Sylvia

AU - Blazer, Dan G.

AU - Meade, Tom W.

AU - Welin, Lennart

AU - Svärdsudd, Kurt

AU - Woodward, Mark

AU - Nissinen, Aulikki

AU - Kromhout, Daan

AU - Jørgensen, Torben

AU - Tilvis, Reijo S.

AU - Guralnik, Jack M.

AU - Rosengren, Annika

AU - Taylor, James O.

AU - Kiechl, Stefan

AU - Dagenais, Gilles R.

AU - Fowkes, F. Gerry R.

AU - Wallace, Robert B.

AU - Khaw, Kay Tee

AU - Shaffer, Jonathan A.

AU - Visser, Marjolein

AU - Kauhanen, Jussi

AU - Salonen, Jukka T.

AU - Gallacher, John

AU - Ben-Shlomo, Yoav

AU - Kitamura, Akihiko

AU - Sundström, Johan

AU - Wennberg, Patrik

AU - Kiyohara, Yutaka

AU - Daimon, Makoto

AU - de la Cámara, Agustin Gómez

AU - Cooper, Jackie A.

AU - Onat, Altan

AU - Devereux, Richard

AU - Mukamal, Kenneth J.

AU - Dankner, Rachel

AU - Knuiman, Matthew W.

AU - Crespo, Carlos J.

AU - Gansevoort, Ron T.

AU - Goldbourt, Uri

AU - Nordestgaard, Børge G.

AU - Shaw, Jonathan E.

AU - Mussolino, Michael

AU - Nakagawa, Hidaeki

AU - Fletcher, Astrid

AU - Kuller, Lewis H.

AU - Gillum, Richard F.

AU - Gudnason, Vilmundur

AU - Assmann, Gerd

AU - Wald, Nicholas

AU - Jousilahti, Pekka R.

AU - Greenland, Philip

AU - Trevisan, Maurizio

AU - Ulmer, Hanno

AU - Butterworth, Adam S.

AU - Folsom, Aaron R.

AU - Davey-Smith, George

AU - Hu, Frank B.

AU - Danesh, John

AU - Simpson, Lara M.

AU - Jungner, Ingmar

AU - Demerath, Ellen W.

AU - Franceschini, Nora

AU - Lutsey, Pamela L.

AU - Pitsavos, Christos

AU - Chrysohoou, Christina

AU - Stefanadis, Christodoulos

AU - Atkins, Robert

AU - Zimmet, Paul Z.

AU - Barr, Elizabeth L.M.

AU - Wannamethee, S. Goya

AU - Morris, Richard W.

AU - Willeit, Johann

AU - Weger, Siegfried

AU - Oberhollenzer, Friedrich

AU - Ebrahim, Shah

AU - Yarnell, John W.G.

AU - Tikhonoff, Valérie

AU - Shay, Christina M.

AU - Garside, Daniel B.

AU - Sutherland, Susan E.

AU - Bachman, David L.

AU - Keil, Julian E.

AU - Kizer, Jorge R.

AU - Psaty, Bruce M.

AU - Tybjærg-Hansen, Anne

AU - Jensen, Gorm B.

AU - Schnohr, Peter

AU - Palmieri, Luigi

AU - Panico, Salvatore

AU - Pilotto, Lorenza

AU - Vanuzzo, Diego

AU - Simons, Judith

AU - McCallum, John

AU - Friedlander, Yechiel

AU - Phillips, Caroline L.

AU - Kohout, Frank J.

AU - Cornoni-Huntley, Joan C.

AU - Wareham, Nicholas J.

AU - Schöttker, Ben

AU - Müller, Heiko

AU - Rothenbacher, Dietrich

AU - Jansson, Jan Håkan

AU - Donfrancesco, Chiara

AU - Vartiainen, Erkki

AU - Harald, Kennet

AU - Salomaa, Veikko

AU - Vasan, Ramachandran S.

AU - Fox, Caroline S.

AU - Pencina, Michael J.

AU - Oizumi, Toshihide

AU - Kayama, Takamasa

AU - Kato, Takeo

AU - Bladbjerg, Else Marie

AU - Møller, Lars

AU - Jespersen, Jørgen

AU - Chetrit, Angela

AU - Lubin, Flora

AU - Eriksson, Henry

AU - Lappas, Georgios

AU - Bengtsson, Calle

AU - Lissner, Lauren

AU - Nagel, Dorothea

AU - Miettinen, Tatu A.

AU - Arima, Hisatomi

AU - Doi, Yasufumi

AU - Ninomiya, Toshiharu

AU - Dekker, Jacqueline M.

AU - Nijpels, Giel

AU - Rimm, Eric B.

AU - Willett, Walter C.

AU - Yamagishi, Kazumasa

AU - Noda, Hiroyuki

AU - Kurl, Sudhir

AU - Tuomainen, Tomi Pekka

AU - Poppelaars, Jan L.

AU - Deeg, Dorly J.H.

AU - De Stavola, Bianca Lucia

AU - Hedblad, Bo

AU - Nilsson, Peter

AU - Blokstra, Anneke

AU - Shea, Steven J.

AU - Thorand, Barbara

AU - Koenig, Wolfgang

AU - Döring, Angela

AU - Nitsch, Dorothea

AU - Grandits, Greg

AU - Tverdal, Aage

AU - Nystad, Wenche

AU - Manson, Joann E.

AU - Hankinson, Susan E.

AU - Bauer, Kenneth A.

AU - Davidson, Karina W.

AU - Kirkland, Susan

AU - Shimbo, Daichi

AU - Sato, Shinichi

AU - Miura, Katsuyuki

AU - Sakurai, Masaru

AU - Jouven, Xavier

AU - Bakker, Stephan J.L.

AU - van der Harst, Pim

AU - Hillege, Hans L.

AU - Garcia-Palmieri, Mario R.

AU - Amouyel, Philippe

AU - Arveiler, Dominique

AU - Ferrières, Jean

AU - Schulte, Helmut

AU - de Craen, Anton J.M.

AU - Sattar, Naveed

AU - Stott, David J.

AU - Cantin, Bernard

AU - Lamarche, Benoît

AU - Després, Jean Pierre

AU - Bergstrom, Jaclyn

AU - Bettencourt, Richele R.

AU - Buisson, Catherine

AU - Aspelund, Thor

AU - Sigurdsson, Gunnar

AU - Thorsson, Bolli

AU - Ikram, M. Arfan

AU - Tiemeier, Henning

AU - Witteman, Jacqueline C.M.

AU - Tavendale, Roger

AU - Lowe, Gordon D.O.

AU - Yeh, Jeun Liang

AU - Ali, Tauqeer

AU - Calhoun, Darren

AU - Can, Günay

AU - Nakamura, Koshi

AU - Morikawa, Yuko

AU - Mathiesen, Ellisiv B.

AU - Løchen, Maja Lisa

AU - Wilsgaard, Tom

AU - Ingelsson, Erik

AU - Michaëlsson, Karl

AU - Cederholm, Tommy

AU - Buring, Julie

AU - Diem, Günter

AU - Concin, Hans

AU - Rodeghiero, Francesco

AU - Marmot, Michael

AU - Kivimaki, Martin Shipley Mika

AU - Robertson, Michele

AU - Feskens, Edith

AU - Geleijnse, Johanna M.

AU - Kromhout, Daan

AU - Walker, Matthew

AU - Watson, Sarah

AU - Alexander, Myriam

AU - Franco, Oscar H.

AU - Gobin, Reeta

AU - Haycock, Philip

AU - Kaptoge, Stephen

AU - Seshasai, Sreenivasa R.Kondapally

AU - Lewington, Sarah

AU - Pennells, Lisa

AU - Rapsomaniki, Eleni

AU - Sarwar, Nadeem

AU - Thompson, Alexander

AU - Thompson, Simon G.

AU - White, Ian R.

AU - Zhao, Xiaohui

PY - 2012/10

Y1 - 2012/10

N2 - Background: The extent to which adult height, a biomarker of the interplay of genetic endowment and early-life experiences, is related to risk of chronic diseases in adulthood is uncertain. Methods: We calculated hazard ratios (HRs) for height, assessed in increments of 6.5 cm, using individual-participant data on 174 374 deaths or major non-fatal vascular outcomes recorded among 1 085 949 people in 121 prospective studies. Results: For people born between 1900 and 1960, mean adult height increased 0.5-1 cm with each successive decade of birth. After adjustment for age, sex, smoking and year of birth, HRs per 6.5 cm greater height were 0.97 (95% confidence interval: 0.96-0.99) for death from any cause, 0.94 (0.93-0.96) for death from vascular causes, 1.04 (1.03-1.06) for death from cancer and 0.92 (0.90-0.94) for death from other causes. Height was negatively associated with death from coronary disease, stroke subtypes, heart failure, stomach and oral cancers, chronic obstructive pulmonary disease, mental disorders, liver disease and external causes. In contrast, height was positively associated with death from ruptured aortic aneurysm, pulmonary embolism, melanoma and cancers of the pancreas, endocrine and nervous systems, ovary, breast, prostate, colorectum, blood and lung. HRs per 6.5 cm greater height ranged from 1.26 (1.12-1.42) for risk of melanoma death to 0.84 (0.80-0.89) for risk of death from chronic obstructive pulmonary disease. HRs were not appreciably altered after further adjustment for adiposity, blood pressure, lipids, inflammation biomarkers, diabetes mellitus, alcohol consumption or socio-economic indicators. Conclusion: Adult height has directionally opposing relationships with risk of death from several different major causes of chronic diseases. Published by Oxford University Press on behalf of the International Epidemiological Association

AB - Background: The extent to which adult height, a biomarker of the interplay of genetic endowment and early-life experiences, is related to risk of chronic diseases in adulthood is uncertain. Methods: We calculated hazard ratios (HRs) for height, assessed in increments of 6.5 cm, using individual-participant data on 174 374 deaths or major non-fatal vascular outcomes recorded among 1 085 949 people in 121 prospective studies. Results: For people born between 1900 and 1960, mean adult height increased 0.5-1 cm with each successive decade of birth. After adjustment for age, sex, smoking and year of birth, HRs per 6.5 cm greater height were 0.97 (95% confidence interval: 0.96-0.99) for death from any cause, 0.94 (0.93-0.96) for death from vascular causes, 1.04 (1.03-1.06) for death from cancer and 0.92 (0.90-0.94) for death from other causes. Height was negatively associated with death from coronary disease, stroke subtypes, heart failure, stomach and oral cancers, chronic obstructive pulmonary disease, mental disorders, liver disease and external causes. In contrast, height was positively associated with death from ruptured aortic aneurysm, pulmonary embolism, melanoma and cancers of the pancreas, endocrine and nervous systems, ovary, breast, prostate, colorectum, blood and lung. HRs per 6.5 cm greater height ranged from 1.26 (1.12-1.42) for risk of melanoma death to 0.84 (0.80-0.89) for risk of death from chronic obstructive pulmonary disease. HRs were not appreciably altered after further adjustment for adiposity, blood pressure, lipids, inflammation biomarkers, diabetes mellitus, alcohol consumption or socio-economic indicators. Conclusion: Adult height has directionally opposing relationships with risk of death from several different major causes of chronic diseases. Published by Oxford University Press on behalf of the International Epidemiological Association

KW - Cancer

KW - Cardiovascular disease

KW - Cause-specific mortality

KW - Epidemiological study

KW - Height

KW - Meta-analysis

UR - http://www.scopus.com/inward/record.url?scp=84867619105&partnerID=8YFLogxK

U2 - 10.1093/ije/dys086

DO - 10.1093/ije/dys086

M3 - Article

VL - 41

SP - 1419

EP - 1433

JO - International Journal of Epidemiology

JF - International Journal of Epidemiology

SN - 0300-5771

IS - 5

M1 - dys086

ER -