Adsorption of bisphosphonate onto hydroxyapatite using a novel co-precipitation technique for bone growth enhancement

Kate McLeod, Gail I. Anderson, Naba K. Dutta, Roger St C. Smart, Nicolas H. Voelcker, Ron Sekel, Sunil Kumar

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Abstract

Premature bone resorption and remodeling by osteoclasts can limit the longevity of implant fixation and recovery time. Orally administered bisphosphonates (BPs) have been used to inhibit osteoclast action at the implant/bone interface. Ideally, these should be delivered at the interface with the osteoblast-active hydroxyapatite (HA) for maximum effect. This investigation introduces a novel BP loading technique to achieve improved BP release from a simulated body fluid-grown HA (SBF-HA) with the aim of improving implant fixation. A solution co-precipitation technique incorporates the BP (pamidronate) into a thin SBF-HA coating. Surface analysis, using X-ray photoelectron spectroscopy (XPS), of the resultant coating was employed to confirm the presence of the adsorbed BP on the surface of SBF-HA. XPS analysis was also used to determine the optimal adsorption process. Osteoclast cell culture experiments confirmed the biological effectiveness of BP adsorption and proved that the pamidronate was biologically active, causing both decreased osteoclast numbers and decreased resorption.

Original languageEnglish
Pages (from-to)271-281
Number of pages11
JournalJournal of Biomedical Materials Research - Part A
Volume79
Issue number2
DOIs
Publication statusPublished - 1 Nov 2006
Externally publishedYes

Keywords

  • Bisphosphonate
  • Hydroxyapatite
  • Osteoclast
  • XPS

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