Adrenoceptor regulation of the mechanistic target of rapamycin in muscle and adipose tissue

Ling Yeong Chia, Bronwyn Evans, Saori Mukaida, Tore Bengtsson, Dana Hutchinson, Masaaki Sato

Research output: Contribution to journalReview ArticleResearchpeer-review

2 Citations (Scopus)

Abstract

A vital role of adrenoceptors in metabolism and energy balance has been well documented in the heart, skeletal muscle, and adipose tissue. It has been only recently demonstrated, however, that activation of the mechanistic target of rapamycin (mTOR) makes a significant contribution to various metabolic and physiological responses to adrenoceptor agonists. mTOR exists as two distinct complexes named mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2) and has been shown to play a critical role in protein synthesis, cell proliferation, hypertrophy, mitochondrial function, and glucose uptake. This review will describe the physiological significance of mTORC1 and 2 as a novel paradigm of adrenoceptor signalling in the heart, skeletal muscle, and adipose tissue. Understanding the detailed signalling cascades of adrenoceptors and how they regulate physiological responses is important for identifying new therapeutic targets and identifying novel therapeutic interventions. Linked Articles: This article is part of a themed section on Adrenoceptors—New Roles for Old Players. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.14/issuetoc.

Original languageEnglish
Pages (from-to)2433-2448
Number of pages16
JournalBritish Journal of Pharmacology
Volume176
Issue number14
DOIs
Publication statusPublished - 1 Jul 2019

Keywords

  • Adrenoceptor
  • mTOR
  • glucose uptake
  • GLUT4
  • skeletal muscle
  • cardiomyocyte

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