Adrenoceptor regulation of mTOR in muscle and adipose tissue

Ling Yeong Chia, Bronwyn Evans, Saori Mukaida, Tore Bengtsson, Dana Hutchinson, Masaaki Sato

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

A vital role of adrenoceptors in metabolism and energy balance has been well‐documented in heart, skeletal muscle, and adipose tissue. It has been only recently demonstrated, however, that activation of mechanistic/mammalian target of rapamycin (mTOR) makes a significant contribution to various metabolic and physiological responses to adrenoceptor agonists. mTOR exists as two distinct complexes named mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2), and has been shown to play a critical role in protein synthesis, cell proliferation, hypertrophy, mitochondrial function, and glucose uptake. This review will describe the physiological significance of mTORC1/2 as a novel paradigm of adrenoceptor signalling in heart, skeletal muscle and adipose tissue. Understanding the detailed signalling cascades of adrenoceptors and how they regulate physiological responses is important for identifying new therapeutic targets and identifying novel therapeutic interventions.
Original languageEnglish
Number of pages38
JournalBritish Journal of Pharmacology
DOIs
Publication statusAccepted/In press - 2019

Keywords

  • Adrenoceptor
  • mTOR
  • glucose uptake
  • GLUT4
  • skeletal muscle
  • cardiomyocyte

Cite this

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title = "Adrenoceptor regulation of mTOR in muscle and adipose tissue",
abstract = "A vital role of adrenoceptors in metabolism and energy balance has been well‐documented in heart, skeletal muscle, and adipose tissue. It has been only recently demonstrated, however, that activation of mechanistic/mammalian target of rapamycin (mTOR) makes a significant contribution to various metabolic and physiological responses to adrenoceptor agonists. mTOR exists as two distinct complexes named mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2), and has been shown to play a critical role in protein synthesis, cell proliferation, hypertrophy, mitochondrial function, and glucose uptake. This review will describe the physiological significance of mTORC1/2 as a novel paradigm of adrenoceptor signalling in heart, skeletal muscle and adipose tissue. Understanding the detailed signalling cascades of adrenoceptors and how they regulate physiological responses is important for identifying new therapeutic targets and identifying novel therapeutic interventions.",
keywords = "Adrenoceptor, mTOR, glucose uptake, GLUT4, skeletal muscle, cardiomyocyte",
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Adrenoceptor regulation of mTOR in muscle and adipose tissue. / Chia, Ling Yeong; Evans, Bronwyn; Mukaida, Saori; Bengtsson, Tore; Hutchinson, Dana; Sato, Masaaki.

In: British Journal of Pharmacology, 2019.

Research output: Contribution to journalReview ArticleResearchpeer-review

TY - JOUR

T1 - Adrenoceptor regulation of mTOR in muscle and adipose tissue

AU - Chia, Ling Yeong

AU - Evans, Bronwyn

AU - Mukaida, Saori

AU - Bengtsson, Tore

AU - Hutchinson, Dana

AU - Sato, Masaaki

PY - 2019

Y1 - 2019

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AB - A vital role of adrenoceptors in metabolism and energy balance has been well‐documented in heart, skeletal muscle, and adipose tissue. It has been only recently demonstrated, however, that activation of mechanistic/mammalian target of rapamycin (mTOR) makes a significant contribution to various metabolic and physiological responses to adrenoceptor agonists. mTOR exists as two distinct complexes named mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2), and has been shown to play a critical role in protein synthesis, cell proliferation, hypertrophy, mitochondrial function, and glucose uptake. This review will describe the physiological significance of mTORC1/2 as a novel paradigm of adrenoceptor signalling in heart, skeletal muscle and adipose tissue. Understanding the detailed signalling cascades of adrenoceptors and how they regulate physiological responses is important for identifying new therapeutic targets and identifying novel therapeutic interventions.

KW - Adrenoceptor

KW - mTOR

KW - glucose uptake

KW - GLUT4

KW - skeletal muscle

KW - cardiomyocyte

U2 - 10.1111/bph.14616

DO - 10.1111/bph.14616

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JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

SN - 1476-5381

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