Adrenal venous sampling with or without adrenocorticotropic hormone stimulation: A meta-analysis

Irakoze Laurent, Manirakiza Astère, Fengfan Zheng, Xiangjun Chen, Jun Yang, Qingfeng Cheng, Qifu Li

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Context: Adrenal venous sampling (AVS), with or without adrenocorticotropic hormone (ACTH) stimulation, is the test of choice to identify patients with a surgically curable subtype of primary aldosteronism (PA). Whether AVS with ACTH stimulation is more effective than AVS without ACTH stimulation remains controversial. Objective: To compare the effectiveness of AVS with ACTH stimulation and AVS without ACTH stimulation in patients with PA. Design: The Cochrane Library, PubMed, Embase, and Web of Science databases were searched to identify relevant articles. All cohort studies comparing the two techniques (AVS with ACTH stimulation and AVS without ACTH stimulation in a patient with PA) were included in the analysis. Results: A total of 14 studies met the inclusion criteria, and they were analyzed. AVS with ACTH stimulation did not significantly reduce the number of incorrect lateralization more than AVS without ACTH stimulation in patients with PA (OR: 0.76; 95% CI: 0.36, 1.59; P = 0.47). AVS with ACTH stimulation significantly reduced the number of unsuccessful cannulations of both adrenal veins more than AVS without ACTH stimulation in patients with PA (OR: 0.26; 95% CI: 0.17, 0.40; P , 0.00001). For subgroup analyses, it also significantly reduced the number of unsuccessful cannulations of left adrenal vein and right adrenal vein (OR: 0.14, 95% CI: 0.06, 0.33, P , 0.00001; and OR: 0.30, 95% CI: 0.12, 0.71, P = 0.007, respectively). Conclusion: AVS with ACTH stimulation can significantly reduce the number of unsuccessful cannulations, without significantly reducing the number of incorrect lateralization. Further studies are still needed to verify these findings.

Original languageEnglish
Pages (from-to)1060-1068
Number of pages9
JournalJournal of Clinical Endocrinology and Metablism
Volume104
Issue number4
DOIs
Publication statusPublished - 1 Apr 2019
Externally publishedYes

Cite this

Laurent, Irakoze ; Astère, Manirakiza ; Zheng, Fengfan ; Chen, Xiangjun ; Yang, Jun ; Cheng, Qingfeng ; Li, Qifu. / Adrenal venous sampling with or without adrenocorticotropic hormone stimulation : A meta-analysis. In: Journal of Clinical Endocrinology and Metablism. 2019 ; Vol. 104, No. 4. pp. 1060-1068.
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title = "Adrenal venous sampling with or without adrenocorticotropic hormone stimulation: A meta-analysis",
abstract = "Context: Adrenal venous sampling (AVS), with or without adrenocorticotropic hormone (ACTH) stimulation, is the test of choice to identify patients with a surgically curable subtype of primary aldosteronism (PA). Whether AVS with ACTH stimulation is more effective than AVS without ACTH stimulation remains controversial. Objective: To compare the effectiveness of AVS with ACTH stimulation and AVS without ACTH stimulation in patients with PA. Design: The Cochrane Library, PubMed, Embase, and Web of Science databases were searched to identify relevant articles. All cohort studies comparing the two techniques (AVS with ACTH stimulation and AVS without ACTH stimulation in a patient with PA) were included in the analysis. Results: A total of 14 studies met the inclusion criteria, and they were analyzed. AVS with ACTH stimulation did not significantly reduce the number of incorrect lateralization more than AVS without ACTH stimulation in patients with PA (OR: 0.76; 95{\%} CI: 0.36, 1.59; P = 0.47). AVS with ACTH stimulation significantly reduced the number of unsuccessful cannulations of both adrenal veins more than AVS without ACTH stimulation in patients with PA (OR: 0.26; 95{\%} CI: 0.17, 0.40; P , 0.00001). For subgroup analyses, it also significantly reduced the number of unsuccessful cannulations of left adrenal vein and right adrenal vein (OR: 0.14, 95{\%} CI: 0.06, 0.33, P , 0.00001; and OR: 0.30, 95{\%} CI: 0.12, 0.71, P = 0.007, respectively). Conclusion: AVS with ACTH stimulation can significantly reduce the number of unsuccessful cannulations, without significantly reducing the number of incorrect lateralization. Further studies are still needed to verify these findings.",
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Adrenal venous sampling with or without adrenocorticotropic hormone stimulation : A meta-analysis. / Laurent, Irakoze ; Astère, Manirakiza ; Zheng, Fengfan ; Chen, Xiangjun; Yang, Jun; Cheng, Qingfeng; Li, Qifu.

In: Journal of Clinical Endocrinology and Metablism, Vol. 104, No. 4, 01.04.2019, p. 1060-1068.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Adrenal venous sampling with or without adrenocorticotropic hormone stimulation

T2 - A meta-analysis

AU - Laurent, Irakoze

AU - Astère, Manirakiza

AU - Zheng, Fengfan

AU - Chen, Xiangjun

AU - Yang, Jun

AU - Cheng, Qingfeng

AU - Li, Qifu

PY - 2019/4/1

Y1 - 2019/4/1

N2 - Context: Adrenal venous sampling (AVS), with or without adrenocorticotropic hormone (ACTH) stimulation, is the test of choice to identify patients with a surgically curable subtype of primary aldosteronism (PA). Whether AVS with ACTH stimulation is more effective than AVS without ACTH stimulation remains controversial. Objective: To compare the effectiveness of AVS with ACTH stimulation and AVS without ACTH stimulation in patients with PA. Design: The Cochrane Library, PubMed, Embase, and Web of Science databases were searched to identify relevant articles. All cohort studies comparing the two techniques (AVS with ACTH stimulation and AVS without ACTH stimulation in a patient with PA) were included in the analysis. Results: A total of 14 studies met the inclusion criteria, and they were analyzed. AVS with ACTH stimulation did not significantly reduce the number of incorrect lateralization more than AVS without ACTH stimulation in patients with PA (OR: 0.76; 95% CI: 0.36, 1.59; P = 0.47). AVS with ACTH stimulation significantly reduced the number of unsuccessful cannulations of both adrenal veins more than AVS without ACTH stimulation in patients with PA (OR: 0.26; 95% CI: 0.17, 0.40; P , 0.00001). For subgroup analyses, it also significantly reduced the number of unsuccessful cannulations of left adrenal vein and right adrenal vein (OR: 0.14, 95% CI: 0.06, 0.33, P , 0.00001; and OR: 0.30, 95% CI: 0.12, 0.71, P = 0.007, respectively). Conclusion: AVS with ACTH stimulation can significantly reduce the number of unsuccessful cannulations, without significantly reducing the number of incorrect lateralization. Further studies are still needed to verify these findings.

AB - Context: Adrenal venous sampling (AVS), with or without adrenocorticotropic hormone (ACTH) stimulation, is the test of choice to identify patients with a surgically curable subtype of primary aldosteronism (PA). Whether AVS with ACTH stimulation is more effective than AVS without ACTH stimulation remains controversial. Objective: To compare the effectiveness of AVS with ACTH stimulation and AVS without ACTH stimulation in patients with PA. Design: The Cochrane Library, PubMed, Embase, and Web of Science databases were searched to identify relevant articles. All cohort studies comparing the two techniques (AVS with ACTH stimulation and AVS without ACTH stimulation in a patient with PA) were included in the analysis. Results: A total of 14 studies met the inclusion criteria, and they were analyzed. AVS with ACTH stimulation did not significantly reduce the number of incorrect lateralization more than AVS without ACTH stimulation in patients with PA (OR: 0.76; 95% CI: 0.36, 1.59; P = 0.47). AVS with ACTH stimulation significantly reduced the number of unsuccessful cannulations of both adrenal veins more than AVS without ACTH stimulation in patients with PA (OR: 0.26; 95% CI: 0.17, 0.40; P , 0.00001). For subgroup analyses, it also significantly reduced the number of unsuccessful cannulations of left adrenal vein and right adrenal vein (OR: 0.14, 95% CI: 0.06, 0.33, P , 0.00001; and OR: 0.30, 95% CI: 0.12, 0.71, P = 0.007, respectively). Conclusion: AVS with ACTH stimulation can significantly reduce the number of unsuccessful cannulations, without significantly reducing the number of incorrect lateralization. Further studies are still needed to verify these findings.

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DO - 10.1210/jc.2018-01324

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